A5092383666- Genomics and Chromatin Dynamics
- Genomics and Phylogenetic Studies
- Diet and metabolism studies
- Histone Deacetylase Inhibitors Research
- Nutrition, Genetics, and Disease
- RNA modifications and cancer
- Fungal and yeast genetics research
- Metabolomics and Mass Spectrometry Studies
- Dietary Effects on Health
- Epigenetics and DNA Methylation
- Gut microbiota and health
University of Colorado Colorado Springs
2023-2025
University of Colorado Anschutz Medical Campus
2024
Abstract Polycomb group (PcG) proteins form chromatin modifying complexes that stably repress lineage- or context-specific genes in animals, plants, and some fungi. Repressive Complex 2 (PRC2) catalyzes trimethylation of lysine 27 on histone H3 (H3K27me3) to assemble repressive chromatin. In the model fungus Neurospora crassa, H3K27me3 deposition is controlled by H3K36 methyltransferase ASH1 components constitutive heterochromatin including H3K9me3-binding protein HETEROCHROMATIN PROTEIN 1...
Chromosomes must correctly fold in eukaryotic nuclei for proper genome function. Eukaryotic organisms hierarchically organize their genomes, including the fungus Neurospora crassa , where chromatin fiber loops compact into Topologically Associated Domain-like structures formed by heterochromatic region aggregation. However, insufficient data exist on how histone posttranslational modifications (PTMs), acetylation, affect organization. In Neurospora, HCHC complex [composed of proteins HDA-1,...
Abstract Motivation Longitudinal microbiome studies (LMS) are increasingly common but have analytic challenges including non-independent data requiring mixed-effects models and large amounts of that motivate exploratory analysis to identify factors related outcome variables. Although change (i.e. calculating deltas between values at different timepoints) can be powerful, how best conduct these analyses is not always clear. For example, observational LMS measurements show natural...
Chromosomes must correctly fold in eukaryotic nuclei for proper genome function. Eukaryotic organisms hierarchically organize their genomes, including the fungus Neurospora crassa, where chromatin fiber loops compact into Topologically Associated Domain (TAD)-like structures formed by heterochromatic region aggregation. However, insufficient data exists on how histone post-translational modifications, acetylation, affect organization. In Neurospora, HCHC complex (comprised of proteins HDA-1,...