A5092383668- Genomics and Phylogenetic Studies
- Genomics and Chromatin Dynamics
- RNA modifications and cancer
- Fungal and yeast genetics research
University of Colorado Colorado Springs
2023
Chromosomes must correctly fold in eukaryotic nuclei for proper genome function. Eukaryotic organisms hierarchically organize their genomes, including the fungus Neurospora crassa , where chromatin fiber loops compact into Topologically Associated Domain-like structures formed by heterochromatic region aggregation. However, insufficient data exist on how histone posttranslational modifications (PTMs), acetylation, affect organization. In Neurospora, HCHC complex [composed of proteins HDA-1,...
Chromosomes must correctly fold in eukaryotic nuclei for proper genome function. Eukaryotic organisms hierarchically organize their genomes, including the fungus Neurospora crassa, where chromatin fiber loops compact into Topologically Associated Domain (TAD)-like structures formed by heterochromatic region aggregation. However, insufficient data exists on how histone post-translational modifications, acetylation, affect organization. In Neurospora, HCHC complex (comprised of proteins HDA-1,...