A5019251905- Chronic Myeloid Leukemia Treatments
- Prostate Cancer Treatment and Research
- Bayesian Methods and Mixture Models
- Single-cell and spatial transcriptomics
- Gene expression and cancer classification
- Radiomics and Machine Learning in Medical Imaging
- T-cell and B-cell Immunology
- Statistical Methods and Inference
- Gene Regulatory Network Analysis
- Medical Imaging Techniques and Applications
- Eosinophilic Disorders and Syndromes
- Immune Cell Function and Interaction
- Radiopharmaceutical Chemistry and Applications
- Image Processing and 3D Reconstruction
- Genetics and Plant Breeding
- Genetic and phenotypic traits in livestock
- Artificial Immune Systems Applications
- Chronic Lymphocytic Leukemia Research
- Cytomegalovirus and herpesvirus research
- Cardiac Imaging and Diagnostics
- Prostate Cancer Diagnosis and Treatment
- Biometric Identification and Security
- Digital Media Forensic Detection
- Neural Networks and Applications
- Genetic Mapping and Diversity in Plants and Animals
CS Diagnostics
2021
Medfield Diagnostics (Sweden)
2019
Progenics Pharmaceuticals (United States)
2018
Lund University
2014-2017
Statistics Sweden
2014
St. Elizabeth's Medical Center
2011
Tufts University
2011
University of California, Berkeley
2011
Centrallasarettet Växjö
1962
<b>Rationale:</b> Standardized staging and quantitative reporting is necessary to demonstrate the association of <sup>18</sup>F-DCFPyL PET/CT (PSMA) imaging with clinical outcome. This work introduces an automated platform implement extend Prostate Cancer Molecular Imaging Evaluation (PROMISE) criteria - aPROMISE. The objective validate performance aPROMISE in quantifying disease burden patients prostate cancer who undergo PSMA Imaging. <b>Methods:</b> was a retrospective analysis 109...
Chronic infection perturbs immune homeostasis. While prior studies have reported dysregulation of effector and memory cells, little is known about the effects on naïve T cell populations. We performed a cross-sectional study chronic hepatitis C (cHCV) patients using tetramer-associated magnetic enrichment to antigen-specific inexperienced CD8 + cells (i.e., tumor or unrelated virus-specific populations in tumor-free sero-negative individuals). cHCV showed normal precursor frequencies, but...
Abstract Purpose The application of automated image analyses could improve and facilitate standardization consistency quantification in [ 18 F]DCFPyL (PSMA) PET/CT scans. In the current study, we analytically validated aPROMISE, a software as medical device that segments organs low-dose CT images with deep learning, subsequently detects quantifies potential pathological lesions PSMA PET/CT. Methods To evaluate learning algorithm, segmentations component scans from 20 patients were compared...
Abstract Background Flow cytometry is a widespread single-cell measurement technology with multitude of clinical and research applications. Interpretation flow data hard; the instrumentation delicate can not render absolute measurements, hence samples only be interpreted in relation to each other while at same time comparisons are confounded by inter-sample variation. Despite this, most automated analysis methods either treat individually or ignore variation for example pooling data. A key...
In exploratory high-dimensional data analysis, local intrinsic dimension estimation can sometimes be used in order to discriminate between sets sampled from different low-dimensional structures. Global estimators many cases adapted estimation, but this leads problems with high negative bias or variance. We introduce a method that exploits the curse/blessing of dimensionality and produces have very low bias, even where is higher than number points, combination relatively show our good ability...
(1962). Angiography in two cases of ergotism. Acta Radiologica: Vol. 57, No. 4, pp. 280-284.
Abstract Chronic myeloid leukemia (CML) is characterized by a specific chromosome translocation, and its pathobiology considered comparatively well understood. Thus, quantitative analysis of CML progression to blast crisis may help elucidate general mechanisms carcinogenesis cancer progression. Hitherto, it has been widely postulated that originates mainly via cell-autonomous such as secondary mutations or genomic instability. However, recent results suggest carcinogenic transformation be an...
Abstract Many automated gating algorithms for flow cytometry data are based on the concept of unimodal cell populations. However, in this article, we show that criteria previously used to make decisions unimodality cannot adequately distinguish from bimodal densities. We dip and bandwidth tests unimodality, taken statistics literature, can do with consistent low error rates. These also have possibility adjust significance level handle trade‐off between failing detect a second mode seeing...
Flow cytometry is a widespread single-cell measurement technology with multitude of clinical and research applications. Interpretation flow data hard; the instrumentation delicate can not render absolute measurements, hence samples only be interpreted in relation to each other while at same time comparisons are confounded by inter-sample variation. Despite this, current automated analysis methods either treat individually or ignore variation for example pooling data. In this article we...
<div>Abstract<p>Chronic myeloid leukemia (CML) is characterized by a specific chromosome translocation, and its pathobiology considered comparatively well understood. Thus, quantitative analysis of CML progression to blast crisis may help elucidate general mechanisms carcinogenesis cancer progression. Hitherto, it has been widely postulated that originates mainly via cell-autonomous such as secondary mutations or genomic instability. However, recent results suggest carcinogenic...
Supplementary Materials from A Multicellular Basis for the Origination of Blast Crisis in Chronic Myeloid Leukemia
Sokal Data from A Multicellular Basis for the Origination of Blast Crisis in Chronic Myeloid Leukemia
Supplementary Materials from A Multicellular Basis for the Origination of Blast Crisis in Chronic Myeloid Leukemia
Sokal Data from A Multicellular Basis for the Origination of Blast Crisis in Chronic Myeloid Leukemia
<div>Abstract<p>Chronic myeloid leukemia (CML) is characterized by a specific chromosome translocation, and its pathobiology considered comparatively well understood. Thus, quantitative analysis of CML progression to blast crisis may help elucidate general mechanisms carcinogenesis cancer progression. Hitherto, it has been widely postulated that originates mainly via cell-autonomous such as secondary mutations or genomic instability. However, recent results suggest carcinogenic...