A5073377628- Effects and risks of endocrine disrupting chemicals
- Innovations in Medical Education
- Congenital Anomalies and Fetal Surgery
- Congenital gastrointestinal and neural anomalies
- Bone fractures and treatments
- Pharmaceutical studies and practices
- Clinical Nutrition and Gastroenterology
- Urological Disorders and Treatments
- Intestinal Malrotation and Obstruction Disorders
- Clinical Reasoning and Diagnostic Skills
- Orthopedic Surgery and Rehabilitation
- Muscle and Compartmental Disorders
- Congenital Diaphragmatic Hernia Studies
- Polymer Science and PVC
- Infant Health and Development
- Vagus Nerve Stimulation Research
- Pediatric Urology and Nephrology Studies
- Sports injuries and prevention
- Radiology practices and education
- Wound Healing and Treatments
- Gastroesophageal reflux and treatments
- Vascular Malformations and Hemangiomas
- Surgical site infection prevention
- Esophageal and GI Pathology
- Orthopedic Infections and Treatments
University Children’s Hospital Basel
2017-2024
University Children's Hospital Zurich
2010-2022
University of Basel
2020-2022
University of Bern
2007-2019
Universität Hamburg
2019
University Medical Center Hamburg-Eppendorf
2019
Boston Children's Hospital
2014
University of Zurich
2011-2012
Heidelberg University
2003-2009
University of Mannheim
2004-2009
INTRODUCTION: Most polyvinylchloride infusion systems are plasticized with up to 60% of di(2-ethylhexyl)phthalate (DEHP). DEHP is easily extracted from the tubing by total parenteral nutrition (TPN) solutions and has been shown have toxic effects on various organ including liver in animals humans. A role was postulated for development hepatobiliary dysfunction premature newborn infants receiving nutrition, incidence cholestasis investigated after changing polyvinylchloride-free systems....
Hirschsprung's disease (HSCR) is a congenital intestinal motility disorder defined by the absence of enteric neuronal cells (ganglia) in distal gut. The development HSCR-associated enterocolitis remains life-threatening complication. Absence ganglia implicates innervation acetylcholine-secreting (cholinergic) nerve fibers. Cholinergic signals have been reported to control excessive inflammation, but impact on unknown.We enrolled 44 HSCR patients prospective multicenter study and grouped them...
For infusion therapy, polyvinylchloride (PVC)-infusion lines are commonly used. In this study, we examined the temperature dependency and dynamics of extraction in time course infusion.PVC-infusion used on newborn ICU were perfused with a typical 24-hour fat infusion. We collected solution measured concentration DEHP. This procedure was carried out at 27 degrees C 33 C. another experiment, rate The every 4 hours.We discovered that DEHP depends highly surrounding temperature. Whereas C,...
The plasticizer di-ethylhexyl-phthalate (DEHP) is extracted especially by lipid emulsions from polyvinylchloride infusion systems. aim of this study was to systematically examine the extraction perfusion lines commonly used in our hospital for emulsion infusions.Perfusion made various lengths and brands, polyethylene, polyvinylchloride/polyethylene (PVC/PE) polyvinylchloride/polyurethane (PVC/PU), were perfused with according circumstances newborns on an intensive care unit, i.e. high...
Except for polyadipate, which is used as an alternative in polyvinylchloride (PVC) feeding tubes, diethylhexylphthalate (DEHP) the plasticizer almost exclusively PVC medical products. A clear response to chronic intake of DEHP has been shown several organ systems from different species. In present study, we compared extraction and polyadipate gastric tubes.An vivo setting was simulated. We 5 cm nasogastric tubes containing or were incubated with juice 1 week a solution 4 weeks. The leakage...
Since the introduction of vacuum-assisted closure (VAC) in 1997, it has been used successfully treating difficult wounds, including spinal wounds and pediatric patients. There are no reports on VAC therapy patients scalp, especially with exposed dura. This report describes a 10-year-old boy chronic wound scalp dura after multiple neurosurgical interventions who was treated VAC.A mentally disabled Apert syndrome suffered from community-associated methicillin-resistant Staphylococcus aureus...
Di(2-ethylhexyl) phthalate (DEHP) is a plasticizer used in many polyvinylchloride medical devices and washed out easily. Thereby critically ill infants can become exposed to DEHP concentrations significantly exceeding the recommended threshold. We suspect play an important role development of intestinal failure-associated liver disease. The aim this study was therefore determine direct influence on different cell types.HepG2, human upcyte hepatocytes, primary murine LX-2, hepatic stellate...
Infants affected by Hirschsprung disease (HSCR), a neurodevelopmental congenital disorder, lack ganglia of the intrinsic enteric nervous system (aganglionosis) in variable length colon, and are prone to developing severe Hirschsprung-associated enterocolitis (HAEC). HSCR patients typically show abnormal dense innervation extrinsic cholinergic nerve fibers throughout aganglionic rectosigmoid. Cholinergic signaling has been reported reduce inflammatory response. Consequently, sparse mucosa...
ABSTRACT Objectives: Recently, our group detected that polyvinyl chloride (PVC) perfusion lines leach large amounts of the toxic plasticizer diethylhexylphthalate (DEHP) under conditions typical intensive care units. In present study, we investigated extraction DEHP from PVC connecting tubes are commonly used for total parenteral nutrition (TPN) solutions. The aim study was to estimate amount which children receiving home TPN exposed months and years. Materials Methods: 1000 mL TPN,...
Background: Looking for a candidate substance inducing hepatobiliary dysfunction under parenteral nutrition (PN) in newborns, we recently discovered that newborn infusions extract large amounts of the plasticizer diethylhexylphthalate (DEHP) from commonly used polyvinylchloride (PVC) infusion lines. This is well known to be genotoxic and teratogenic animals cause changes various organs enzyme systems even humans. The aim this study was examine effect DEHP, extracted same way amount as on...
We report on a 9-year-old girl who was involved in car accident. She suffered severe polytrauma with torn abdominal muscles, rupture of the mesenteric arteries, bowel and bladder, hematoma at right colonic flexure disruption intervertebral ligaments L2/L3, including disc, typical Chance fracture. The bleeding stopped, resected fracture fixed by internal fixation. patient developed postoperative enterocutaneous fistula flank paraplegia. underwent three laparotomies ileostomy closure fistula....
Acute compartment syndrome (ACS) can lead to irreversible damage if fasciotomy is not performed in a timely manner. Needle manometry tool confirm suspected ACS. The threshold for pressures that be tolerated has been debated. aim of this study assess the normal noninjured forearms children. Further, we sought quantify maximum tolerable fractured children, thus establishing baseline and providing guidance evidence-based decision making evaluate children with ACS.This prospective included up...
Hepatic gene therapy by delivering non-integrating therapeutic vectors in newborns remains challenging due to the risk of dilution and loss efficacy growing liver. Previously we reported on hepatocyte transfection piglets intraportal injection naked DNA vectors. Here, established delivery target periportal hepatocytes weaned pigs hydrodynamic retrograde intrabiliary (HRII). The surgical procedure involved laparotomy transient isolation For vector delivery, a catheter was placed within common...
Dermatofibrosarcoma protuberans (DFSP) in childhood is a rare tumor with high recurrence rates. Wide local excision can result disfiguring mutilation, whereas Mohs micrographic surgery (MMS) reduces surgical margins. MMS children not performed routinely, as the required infrastructures such histopathology lab close proximity to operating room often lacking. We retrospectively reviewed diagnosed DFSP treated at our hospital over 2 years. recorded treatment details, including margins, duration...
The purpose of this single-centre randomized controlled trial was to assess the non-inferiority buddy taping versus splint immobilization extra-articular paediatric finger fractures. Secondary fracture displacement primary outcome; patient comfort, cost and range motion were secondary outcomes. Ninety-nine children randomly assigned or splinting. Sixty-nine fractures undisplaced; 31 displaced required reduction before occurred in one three splinting group. risk difference below predefined...
<b>Introduction</b> Failure to detect and treat partial or complete avulsions of the nail bed may lead severe deformity that predisposes repeat injuries is cosmetically inacceptable. Treatment these with split-thickness grafts (STNBGs) controversial no pediatric series has been published. <b>Methods</b> A retrospective, single center case nine fingers complex were reconstructed primarily STNBGs was performed. Surgical outcome patient satisfaction assessed. <b>Results</b> For six...
Surgical treatment of esophageal atresia (EA) has markedly improved, allowing the focus to shift from short-term complications and mortality long-term quality life. Health-related life (HRQoL) is variable reported range reduced unimpaired in patients with repaired EA. We assessed HRQoL, determined prevalence their possible impact on HRQoL who had correction EA Switzerland. Further, we also investigated general well-being parents. Patients repair Switzerland between 1985 2011 were enrolled....
Multisource feedback (MSF), also called 360-degree assessment, is one form of assessment used in postgraduate training. However, there an ongoing discussion on its value, because the factors that influence impact MSF and main are not fully understood. In this study, we investigated both influencing residency training.We conducted a qualitative case study within boundaries training for paediatricians paediatric surgeons at University Hospital. We collected data from seven focus group...
Introduction Evidence-based guidelines or protocols regarding the perinatal management of babies born with gastroschisis are lacking. The aim this work is to evaluate different current treatment modalities for newborns during period in German-speaking countries Germany, Austria, and Switzerland. These data could serve as a starting point development multicenter randomized controlled trial. Materials Methods A questionnaire was developed 30 questions divided into five sections: (1) prenatal...