Katja Herzog
A5075806846- Scientific Computing and Data Management
- Research Data Management Practices
- Plant tissue culture and regeneration
- Computational Drug Discovery Methods
- SARS-CoV-2 and COVID-19 Research
- Plant Reproductive Biology
- Transgenic Plants and Applications
- Persona Design and Applications
- thermodynamics and calorimetric analyses
- Protein Degradation and Inhibitors
- Signaling Pathways in Disease
- Telemedicine and Telehealth Implementation
- Plant Physiology and Cultivation Studies
- Genetically Modified Organisms Research
- Congenital Ear and Nasal Anomalies
- Horticultural and Viticultural Research
- Hedgehog Signaling Pathway Studies
- RNA and protein synthesis mechanisms
- Digital Innovation in Industries
- Fermentation and Sensory Analysis
- COVID-19 Clinical Research Studies
- Trace Elements in Health
- Cancer therapeutics and mechanisms
- Renal and related cancers
- Data-Driven Disease Surveillance
Leibniz Association
2019
Max Delbrück Center
2016
University of Hohenheim
2006
Compound repurposing is an important strategy for the identification of effective treatment options against SARS-CoV-2 infection and COVID-19 disease. In this regard, main protease (3CL-Pro), also termed M-Pro, attractive drug target as it plays a central role in viral replication by processing polyproteins pp1a pp1ab at multiple distinct cleavage sites. We here report results program involving 8.7 K compounds containing marketed drugs, clinical preclinical candidates, small molecules...
Worldwide, there are intensive efforts to identify repurposed drugs as potential therapies against SARS-CoV-2 infection and the associated COVID-19 disease. To date, anti-inflammatory drug dexamethasone (to a lesser extent) RNA-polymerase inhibitor remdesivir have been shown be effective in reducing mortality patient time recovery, respectively, patients. Here, we report results of phenotypic screening campaign within an EU-funded project (H2020-EXSCALATE4COV) aimed at extending repertoire...
Compound screening in biological assays and subsequent optimization of hits is indispensable for the development new molecular research tools drug candidates. To facilitate such discoveries, European Research Infrastructure EU-OPENSCREEN was founded recently with support its member countries Commission. Its distributed character harnesses complementary knowledge, expertise, instrumentation discipline chemical biology from 20 partners, open working model ensures that academia industry can...
The Horizon Europe project ISIDORe is dedicated to pandemic preparedness and responsiveness research. It brings together 17 research infrastructures (RIs) networks provide a broad range of services infectious disease researchers. An efficient structured treatment data central ISIDORe’s aim furnish seamless access its multidisciplinary catalogue services, ensure that users’ results are treated FAIRly. therefore requires management plan (DMP) covering both outputs, applicable over disciplines,...
Abstract Compound repurposing is an important strategy for the identification of effective treatment options against SARS-CoV-2 infection and COVID-19 disease. In this regard, main protease (3CL-Pro), also termed M-Pro, attractive drug target as it plays a central role in viral replication by processing polyproteins pp1a pp1ab at multiple distinct cleavage sites. We here report results program involving 8.7 K compounds containing marketed drugs, clinical preclinical candidates, small...
Eines der wichtigsten Ziele gentechnologischer Arbeiten ist die Erzeugung transgener Kulturpflanzen ohne Verwendung von Selektionsmarkergenen. Die Selektion Zellen erfolgt beim Apfel (Malus x domestica BORKH.) in Regel im Anschluss an einen Agrobacterium tumefaciens-vermittelten Gentransfer mit dem nptII/Kanamycin-System. Im Oktober 2002 wurde eine neue EU-Freisetzungsrichtlinie (2001/18/EG) rechtskraftig. Rahmen dieser Richtlinie vorgesehen, dass Markergenen, insbesondere...