A5009876996- Scientific Computing and Data Management
- Biomedical Text Mining and Ontologies
- Genetics, Bioinformatics, and Biomedical Research
- Research Data Management Practices
- Genomics and Phylogenetic Studies
- Semantic Web and Ontologies
- Advanced Proteomics Techniques and Applications
- Bioinformatics and Genomic Networks
- Distributed and Parallel Computing Systems
- Gene expression and cancer classification
- RNA and protein synthesis mechanisms
- Metabolomics and Mass Spectrometry Studies
- Mass Spectrometry Techniques and Applications
- Carcinogens and Genotoxicity Assessment
- Cell Image Analysis Techniques
- Environmental DNA in Biodiversity Studies
- Peptidase Inhibition and Analysis
- Molecular Biology Techniques and Applications
- Health, Environment, Cognitive Aging
- Cancer Genomics and Diagnostics
- Dialysis and Renal Disease Management
- Blood Pressure and Hypertension Studies
- Wikis in Education and Collaboration
- DNA and Nucleic Acid Chemistry
- Atrial Fibrillation Management and Outcomes
Ospedale Policlinico San Martino
2015-2024
Bambino Gesù Children's Hospital
2023
Metropolitana Milanese (Italy)
2018
Tecnologie Avanzate (Italy)
2016
National Cancer Research Institute
2005-2015
Istituti di Ricovero e Cura a Carattere Scientifico
2012
Alleanza Contro il Cancro
1983-2012
University of Genoa
1990-2011
Genome Research Foundation
2011
National University of Quilmes
2011
The Cell Line Data Base (CLDB) is a well-known reference information source on human and animal cell lines including more than 6000 lines. Main biological features are coded according to controlled vocabularies derived from international lists taxonomies. HyperCLDB (http://bioinformatics.istge.it/hypercldb/) hypertext version of CLDB that improves data accessibility by also allowing retrieval through web spiders. Access provided indexes characteristics navigation in the granted many internal...
Life sciences are yielding huge data sets that underpin scientific discoveries fundamental to improvement in human health, agriculture and the environment. In support of these discoveries, a plethora databases tools deployed, technically complex diverse implementations, across spectrum disciplines. The corpus documentation resources is fragmented Web, with much redundancy, has lacked common standard information. outcome scientists must often struggle find, understand, compare use best for...
Persistent atrial fibrillation (AF) often recurs after direct current electrical cardioversion (ECV). As several experimental and clinical studies suggest that n-3 polyunsaturated fatty acids (PUFAs) may have antiarrhythmic properties even at the level, we aimed to evaluate whether oral supplementation with PUFAs, in addition conventional drugs, could reduce recurrence rate of arrhythmia ECV persistent AF. Two hundred four patients (mean age 69.3 years, 33% females) AF were randomly assigned...
Advanced research requires intensive interaction among a multitude of actors, often possessing different expertise and usually working at distance from each other. The field collaborative aims to establish suitable models technologies properly support these interactions. In this article, we first present the reasons for an interest Bioinformatics in context by also suggesting some domains that could benefit research. We then review principles most relevant applications social networking,...
The main goals and challenges for the life science communities in Open Science framework are to increase reuse sustainability of data resources, software tools, workflows, especially large-scale data-driven research computational analyses. Here, we present key findings, procedures, effective measures recommendations generating establishing sustainable resources based on collaborative, cross-disciplinary work done within EOSC-Life (European Cloud Life Sciences) consortium. Bringing together...
Biology is generating more data than ever. As a result, there an ever increasing number of publicly available databases that analyse, integrate and summarize the data, providing invaluable resource for biological community. this trend continues, pressing need to organize, catalogue rate these resources, so information they contain can be most effectively exploited. MetaBase (MB) (http://MetaDatabase.Org) community-curated database containing 2000 commonly used databases. Each entry...
The huge amount of biological information, its distribution over the Internet and heterogeneity available software tools makes adoption new data integration analysis network a necessity in bioinformatics. ICT standards tools, like Web Services Workflow Management Systems (WMS), can support creation deployment such systems. Many are already some WMS have been proposed. They assume that researchers know which bioinformatics resources be reached through programmatic interface they skilled...
Network Tools and Applications in Biology (NETTAB) [1] is a series of workshops focused on the most promising innovative Information Communication Technologies (ICT) tools to their usefulness Bioinformatics. These aim at introducing participants network standards technologies that are being applied biology field. To this end, each year special emphasis given focus theme. Workshops also include sessions devoted both general theme workshops, i.e. “Network Biology”, further topics selected by...
Mass spectrometry (MS) is producing high volumes of data supporting oncological sciences, especially for translational research. Most related elaborations can be carried out by combining existing tools at different levels, but little currently available the automation fundamental steps. For analysis MALDI/TOF spectra, a number pre-processing steps are required, including joining isotopic abundances given molecular species, normalization signals against an internal standard, background noise...
In this paper we provide an introduction to the techniques for multi-scale complex biological systems, from single bio-molecule cell, combining theoretical modeling, experiments, informatics tools and technologies suitable biomedical research, which are becoming increasingly multidisciplinary, multidimensional information-driven. The most important concepts on mathematical modeling methodologies statistical inference, bioinformatics standards investigate systems discussed prominent...
To date, the 5-year overall survival rate of 60% for early-stage non-small cell lung cancer (NSCLC) is still unsatisfactory. Therefore, reliable prognostic factors are needed. Growing evidence shows that progression may depend on an interconnection between cells and surrounding tumor microenvironment; hence, circulating molecules represent promising markers recurrence. In order to identify a score, we performed in-depth high-throughput analyses plasma markers, including exosomal microRNAs...
MALDI-TOF MS was used to recognise serum peptidome profiles predictive of mortality in women affected by early BCa. Mortality analysed based on signal profiling, and appropriate statistics were used. The results indicate that four signals increased deceased patients compared with living patients. Three the individually associated all-cause mortality, but only one having mass/charge ratio (m/z) 1,046.49 BCa-specific peak maintain an independent prognostic role after multivariate analysis. Two...
Colorectal and glioblastoma cancer stem-like cells (CSCs) are essential for translational research. Cell line authentication by short tandem repeat (STR) profiling ensures reproducibility of results in oncology This technique enables to identify mislabeling or cross-contamination cell lines. In our study, we provide a reference dataset panel colorectal CSCs that allows authentication. Each was entered into the Line Integrated Molecular Authentication database 2.1 be compared STR profiles...
In this report we have raised the question whether genotoxic carcinogens are more potent than nongenotoxic when studied in long-term carcinogenicity assays rodents. To build a large database of compounds for which both and genotoxicity had been investigated, used produced by Gold co-workers carcinogenic potency data (975 chemicals) Würgler (2834 chemicals). Considering positive or negative at least three short-term tests 75% available tests, could define 67 46 carcinogens. Carcinogenic was...
We have already demonstrated that in chronic hemodialysis (HD) patients, the cyclic variations both hydration status and blood pressure are responsible for changes pulse wave velocity (PWV). The aim of this study is to verify whether variation PWV influences mortality dialysis patients. studied 167 oligoanuric (urinary output <500 mL/day) patients on standard bicarbonate HD at least 6 months. They performed 3 sessions 4 hours per week. Patients were classified into groups: normal before...
The Horizon Europe project ISIDORe is dedicated to pandemic preparedness and responsiveness research. It brings together 17 research infrastructures (RIs) networks provide a broad range of services infectious disease researchers. An efficient structured treatment data central ISIDORe’s aim furnish seamless access its multidisciplinary catalogue services, ensure that users’ results are treated FAIRly. therefore requires management plan (DMP) covering both outputs, applicable over disciplines,...
Due to the huge volume and complexity of biological data available today, a fundamental component biomedical research is now in silico analysis. This includes modelling simulation systems processes, as well automated bioinformatics analysis high-throughput data. The quest for resources (including databases, tools, knowledge) becomes therefore extreme importance. Bioinformatics itself rapid evolution dedicated Grid cyberinfrastructures already offer easier access sharing resources....