A5007517262- Genetics, Aging, and Longevity in Model Organisms
- Nutrition, Genetics, and Disease
- Pharmacogenetics and Drug Metabolism
- Animal Diversity and Health Studies
- Telomeres, Telomerase, and Senescence
- Drug Transport and Resistance Mechanisms
- Genetic Associations and Epidemiology
- Healthcare Systems and Public Health
- Molecular Biology Techniques and Applications
- Romani and Gypsy Studies
- Autopsy Techniques and Outcomes
- Migration, Aging, and Tourism Studies
- Immune Response and Inflammation
- Plant-Microbe Interactions and Immunity
- Health disparities and outcomes
- Medical and Biological Sciences
- T-cell and B-cell Immunology
- Frailty in Older Adults
- Aquaculture disease management and microbiota
- Forensic Anthropology and Bioarchaeology Studies
- Environmental and Biological Research in Conflict Zones
- Pharmaceutical studies and practices
- Mitochondrial Function and Pathology
- Digestive system and related health
- FOXO transcription factor regulation
Institute for Anthropological Research
2021-2024
University of Zagreb
2016
A significant portion of the variability in complex features, such as drug response, is likely caused by human genetic diversity. One highly polymorphic pharmacogenes CYP2D6, encoding an enzyme involved metabolism about 25% commonly prescribed drugs. In a directed search 1000 Genomes Phase III variation data, 86 single nucleotide polymorphisms (SNPs) CYP2D6 gene were extracted from genotypes 2504 individuals 26 populations, and then used to reconstruct haplotypes. Analyses performed using...
Longevity is a hallmark of successful ageing and complex trait with significant genetic component. In this study, 43 single nucleotide polymorphisms (SNPs) were chosen from the literature genotyped in Croatian oldest-old sample (85+ years, size (N) = 314), order to determine whether any these SNPs have effect on reaching age thresholds for longevity (90+ N 212) extreme (95+ 84). The best models selected both survival ages using multivariate logistic regression. model 90, nine explained 20%...
Genome-wide association studies and candidate gene have identified several genetic variants that might play a role in achieving longevity. This study investigates interactions between pairs of those single nucleotide polymorphisms (SNPs) their effect on survival above the age 85 sample 327 Croatian individuals. Although none SNPs individually showed significant this sample, 14 359 tested (between not LD) reached level nominal significance (p<0.05), showing potential late-life survival....
The Roma population suffers from severe poverty, social exclusion, and some of the worst health conditions in industrialized world. Herein, we report on cardiovascular disease (CVD) risk factors Ukrainian present a meta-analysis prevalence CVD 16 populations worldwide. meta-analyses (n = 16,552) vs. non-Roma majority same country 127,874) included publicly available data. field survey 339 adults both sexes outcomes interest were hypertension, body mass index (BMI), smoking, education,...
To compare the Croatian and European population in terms of allele frequencies clinically relevant polymorphisms drug absorption, distribution, metabolism, excretion (ADME) genes.In 429 participants, we genotyped 27 loci 20 ADME genes. The obtained were merged with published for by sample size weighting. study this way was compared average data from gnomAD database.Variant higher three lower two (Benjamini-Hochberg-corrected P values: 0.0027 CYP2B6*4 rs2279343, CYP2C9*2 rs1799853, VKORC1...
We examined dermatoglyphics of children in three Albanian and one Roma population sample (collected from 641 individuals the populations 226 both sexes). compared based on four finger (whorl, radial ulnar loop, arch) thirteen palmar traits (pattern frequencies Thenar/I interdigital area, II, III, IV Hypothenar axial »t« triradius position). The differences between were more evident for traits. In our study showed best separation when are separately analyzed. As expected, separated...
Some sources report a connection of cellular senescence with chronic pathological conditions; however, the association between particular processes and general health is rarely examined. This study aims to test relationship DNA damage pathways that play crucial role in senescence. The ten selected SNPs subjective objective functional ability indicators has been tested 314 oldest-old people from Croatia. Multivariate logistic regression was employed simultaneously impact variables potentially...
The CYP2D6 gene encodes an enzyme responsible for the metabolism of ~20% clinically prescribed drugs. In this study, 18 SNPs from enhancer and promoter regions in 323 Roma Croatia were genotyped, to find out whether demographic history affected distribution studied their linkage disequilibrium (LD) values, with major defining star alleles. No differences found between three groups allele genotype frequencies. LD values was compared European Asian populations. Regulatory (rs5758550,...