A5038775993- Lipid Membrane Structure and Behavior
- Advanced Polymer Synthesis and Characterization
- Spectroscopy and Quantum Chemical Studies
- Protein Structure and Dynamics
- Nanopore and Nanochannel Transport Studies
- Neurological Disease Mechanisms and Treatments
- Metabolomics and Mass Spectrometry Studies
- Eicosanoids and Hypertension Pharmacology
- Polymer Surface Interaction Studies
- Nanoparticle-Based Drug Delivery
- Neuroscience and Neuropharmacology Research
- Microfluidic and Capillary Electrophoresis Applications
- Antioxidant Activity and Oxidative Stress
Louisiana State University
2018-2022
We investigated the molecular dynamics of unilamellar liposomes by neutron spin echo spectroscopy. report first experimental evidence a short-range motion at length scale size headgroup lipid. The associated mean squared displacement shows t0.26 dependence in pico- to nanosecond region that indicates another process beyond predictions Zilman–Granek (ZG) model (t0.66) and translational diffusion (t1). A comparison with theory observed low exponent is non-Gaussian transient trapping lipid...
Sodium chloride (NaCl) is a very common molecule in biotic and abiotic aqueous environments. In both cases, variation of ionic strength inevitable. addition to the osmotic posed by such perturbations, question whether interactions monovalent ions Na+ Cl–, especially with neutral head groups phospholipid membranes are impactful enough change membrane rigidity, still not entirely understood. We investigated dynamics 1,2-di-(octadecenoyl)-sn-glycero-3-phosphocholine (DOPC) vesicles zwitterionic...
Hybrid vesicles resulting from combined self-assembly of polymers and lipids have gained interest in recent years as drug delivery systems, biosensors, model systems for structural scaffolds artificial organelles. So far, the literature, more attention has been given to study how discrepancy chemical compositions hydrophobic segment sizes between affect vesicle's nature. In this study, we focused on hydrophilic blocks impact morphology. Therefore, developed hybrid lipid/polymer vesicle with...
Polymersomes frequently appear in the literature as promising candidates for a wide range of applications from targeted drug delivery to nanoreactors.
Micelles and vesicles are promising candidates in targeted drug/gene delivery, bioreactors, templates for nanoparticle synthesis. We investigated the morphology dynamics of PEG-PDMS-PEG triblock copolymer nano-scale assemblies regarding membrane because molecular govern mechanical properties like stability a membrane. studied structure by cryogenic transmission electron microscopy, small-angle neutron scattering, dynamic light scattering spin echo spectroscopy. changed length hydrophilic...
Salt is a very common molecule in aqueous environments but the question of whether interactions monovalent ions Na^+ and Cl^- ,with neutral heads phospholipids are impactful enough to change membrane rigidity still mystery. To provide resolution this long simmering debate, we investigated dynamics DOPC vesicles fluid phase with increasing external salt concentration. At higher concentrations, observe an increase bending from neutron spin echo spectroscopy (NSE) bilayer thickness small-angle...
At the onset and progression of neurodegenerative diseases, enhanced reactive oxygen species (ROS) an overall uncompensated oxidative stress environment evolve. Oxidized phospholipids (OxPLs) cause detrimental perturbations to synaptic membranes other parts nervous system. We tested if lipid mediators Elovanoids (ELVs) that exert neuroprotective signaling also counteract peroxidation using experimental ischemic stroke model. Male Sprague-Dawley rats after 2 hours middle cerebral artery...
Age-related macular degeneration (AMD) accumulates amyloid-beta peptide as in senile plaques of Alzheimer's. Also, other neurodegenerative diseases, enhanced reactive oxygen species (ROS) and an overall uncompensated oxidative stress (UOS) environment evolve. Oxidized phospholipids (OxPLs) cause detrimental perturbations to photoreceptor cells (PRC) the retinal pigment epithelial cell (RPEC), a nondividing derived from neuroectoderm, essential for PRC integrity. Elovanoids (ELVs) are lipid...