A5084790630- Extracellular vesicles in disease
- RNA Interference and Gene Delivery
- MicroRNA in disease regulation
- Nanoparticle-Based Drug Delivery
- Cardiac Ischemia and Reperfusion
- Advanced Drug Delivery Systems
- Nanoplatforms for cancer theranostics
- Advancements in Transdermal Drug Delivery
- Immunotherapy and Immune Responses
- Drug Solubulity and Delivery Systems
- Nanopore and Nanochannel Transport Studies
- Circular RNAs in diseases
- Adenosine and Purinergic Signaling
- Fatty Acid Research and Health
- Neuroinflammation and Neurodegeneration Mechanisms
- Natural Compounds in Disease Treatment
- Cardiac Fibrosis and Remodeling
- Curcumin's Biomedical Applications
- ATP Synthase and ATPases Research
- Traditional Chinese Medicine Analysis
- Biopolymer Synthesis and Applications
- Heme Oxygenase-1 and Carbon Monoxide
- Seaweed-derived Bioactive Compounds
- Bacterial Infections and Vaccines
- Berberine and alkaloids research
Second Xiangya Hospital of Central South University
2013-2025
Central South University
2013-2025
Xiangya Hospital Central South University
2019
Hunan University of Traditional Chinese Medicine
2013
Extracellular vesicles (EVs) are nanovesicles involved in multiple biological functions. Small EVs (sEVs) emerging as therapeutics and drug delivery systems for their contents, natural carrier properties, nanoscale size. Despite various clinical application potentials, little is known about the effects of storage conditions on sEVs functional analysis therapeutic use. In this study, we evaluated stability stored at 4 °C, -20 -80 °C up to 28 days compared them fresh sEVs. Also, effect...
Bacterial outer membrane vesicles (OMVs) are potent immuno-stimulating agents and have the potentials to be bioengineered as platforms for antitumor nanomedicine. In this study, OMVs demonstrated promising therapeutics. can lead beneficial M2-to-M1 polarization of macrophages induce pyroptosis enhance immunity, but therapeutic window is narrow its toxicity. We propose a bioengineering strategy tumor-targeting ability by macrophage-mediated delivery improve efficacy co-loading photosensitizer...
The protective role of puerarin (PUE) against myocardial infarction is closely related to its regulation on mitochondria. However, free PUE can hardly reach the mitochondria ischemic cardiomyocytes due lack mitochondrial targeting PUE. Here was loaded into mitochondria-targeted micelles (PUE@TPP/PEG-PE) for precisely delivering with aim enhancing anti-apoptosis effect.The mitochondriotropic polymer TPP-PEG-PE synthesized preparation PUE@TPP/PEG-PE modified triphenylphosphonium (TPP) cation....
Targeted drug delivery to the glioblastoma (GBM) overcoming blood-brain barrier (BBB) has been challenging. Exosomes are promising vehicles for brain tumor delivery, but production and purification hinder its application nanomedicine. Besides, formation of protein corona (PC) may affect behaviour nanocarriers. Here, multifunctional exosomes-mimetics (EM) developed decorated with angiopep-2 (Ang) enhancing GBM by manipulating PC. Docetaxel (DTX)-loaded EM Ang modification (DTX@Ang-EM) show...
Acute myocardial infarction, characterized by high morbidity and mortality, has now become a serious health hazard for human beings. Conventional surgical interventions to restore blood flow can rapidly relieve acute ischemia, but the ensuing ischemia-reperfusion injury (MI/RI) subsequent heart failure have medical challenges that researchers been trying overcome. The pathogenesis of MI/RI involves several mechanisms, including overproduction reactive oxygen species, abnormal mitochondrial...
The purpose of the present work was to determine mechanisms by which microemulsions (MEs) enhance oral bioavailability puerarin. in situ perfusion method used rats study absorption an oil-in-water (O/W) microemulsion (O/W-ME) and a water-in-oil (W/O) (W/O-ME). possibility lymphatic transport MEs investigated using chylomicron flow blocking approach. results for stomach intestines indicated that characteristics O/W-ME W/O-ME depend on segment. had higher internal membrane permeability than...
Berberine hydrochloride (BBH) has a variety of pharmacological activities such as antitumor, antimicrobial, anti-inflammation, and reduce irritable bowel syndrome. However, poor stability low oral bioavailability limited its usage. Herein, an oil-in-water nanoemulsion system BBH was developed to improve bioavailability. The pseudoternary phase diagrams were constructed for the determination composition various nanoemulsions. nanoemulsions composed Labrafil M 1944 CS (oil phase), RH-40...
Puerarin (PUE) and tetramethylpyrazine (TMP) are central nervous system (CNS) drugs used in cerebrovascular diseases. Poor brain-blood barrier (BBB) permeability limited their clinical application. Borneol α-asarone have been proposed as an oral brain-targeting enhancer. In this study, we aimed to first evaluate the 'orifice-opening' effect of borneol α-asarone, both aromatic resuscitation drugs, on improvement brain delivery PUE TMP second investigate whether enhancing effects were...
Glioblastoma multiforme (GBM) is characterized by pronounced immune escape and resistance to chemotherapy-induced apoptosis. Preliminary investigations revealed a marked overexpression of gasdermin E (GSDME) in GBM. Notably, cisplatin (CDDP) demonstrated capacity inducing pyroptosis activating caspase-3 cleave GSDME, coupled with the release proinflammatory factors, indicating potential as viable approach anti-tumor activation. For effective delivery CDDP, CDDP-polyphenol nanocomplexes were...
Photodynamic therapy (PDT) is a promising strategy with significant clinical application potential for tumor treatment. However, the hypoxia and limited efficacy against metastasis present limitations in of PDT. To alleviate PDT growth metastasis, we developed self-oxygenated immunoliposome by encapsulating catalase (CAT) within liposome cavity loading photosensitizer chlorin e6 (Ce6) immunoadjuvant MPLA lipid bilayer (CAT@LP-Ce6-A). Subsequently, fused it cancer cell membrane (CCM) to...
Abstract Acute inflammation has the potential for recruitment of immune cells, inhibiting tumor angiogenesis, metastasis, and drug resistance thereby overcoming immunosuppressive microenvironment caused by chronic inflammation. Here, an acute inducer using bacteria outer membrane vesicles (OMVs) loaded in thermal‐sensitive hydrogel (named OMVs‐gel) localized controlled release OMVs sites is proposed. trigger neutrophil amplify inside tissues. The ensures drastic confined within tumor,...
Puerarin is a phytochemical with various pharmacological effects, but poor water solubility and low oral bioavailability limited usage of puerarin. The purpose this study was to develop new microemulsion (ME) based on phospholipid complex technique improve the (PPC) prepared by solvent evaporation method characterized X-ray diffraction infrared spectroscopy. Pseudo-ternary phase diagrams were constructed investigate effects different oil emulsifying performance blank ME. Intestinal mucosal...
Purpose: The aim of this research was to develop a phospholipid complex based nanoemulsion system for oral insulin delivery. Methods: Insulin-phospholipid (IPC) firstly prepared by an anhydrous co-solvent lyophilization method, and then encapsulated into the oil phase obtain IPC-based (IPC-NE). Both water-in-oil (W/O) IPC-NE oil-in-water (O/W) were formulated evaluated comparison. Results: obtained W/O O/W both spherical in shape with mean particle size 18.6±0.79 nm 27.3±1.25 nm,...
Abstract Background Small extracellular vesicles (sEVs) are nanosized involved in cell-to-cell communication. sEVs have been widely studied for clinical applications such as early detection of diseases and therapeutics. Various methods isolation using, but different may result qualities impact downstream analysis applications. Here, we compared current performed a comparative from supernatant cultured pancreatic cancer cells. Methods Ultracentrifugation, ultrafiltration co-precipitation...
Mitochondrial damage may lead to uncontrolled oxidative stress and massive apoptosis, thus plays a pivotal role in the pathological processes of myocardial ischemia-reperfusion (I/R) injury. However, it is difficult for drugs such as puerarin (PUE) reach mitochondrial lesion due lack targeting ability, which seriously affects expected efficacy drug therapy I/R
8-methoxypsoralen (8-MOP) is one of the most commonly utilized drugs in psoralen-ultraviolet A therapy for treatment vitiligo. However, poor skin retention and systemic side effects limit clinical application 8-MOP.Microemulsions (MEs) chitosan derivative-coated 8-MOP MEs were developed compared dermal delivery 8-MOP. Ex vivo retention/permeation study was performed to select ME formulation with highest retention:permeation ratio. Four different chitosan-coated prepared their ability...