A5077356864- RNA Research and Splicing
- Nuclear Structure and Function
- Genomics and Chromatin Dynamics
- Muscle Physiology and Disorders
- Microtubule and mitosis dynamics
- Adipokines, Inflammation, and Metabolic Diseases
- Chronic Lymphocytic Leukemia Research
- Biotin and Related Studies
- Cancer-related Molecular Pathways
- Cancer-related molecular mechanisms research
University of Oslo
2018-2023
Oslo University Hospital
2023
Interactions of chromatin with the nuclear lamina via lamina-associated domains (LADs) confer structural stability to genome. The dynamics positioning LADs during differentiation, and how impinge on developmental gene expression, remains, however, elusive.
The nuclear lamina provides a repressive chromatin environment at the periphery. However, whereas most genes in lamina-associated domains (LADs) are inactive, over ten percent reside local euchromatic contexts and expressed. How these regulated whether they able to interact with regulatory elements remain unclear. Here, we integrate publicly available enhancer-capture Hi-C data our own state transcriptomic datasets show that inferred enhancers of active LADs form connections other within...
The ability to recapitulate muscle differentiation in vitro enables the exploration of mechanisms underlying myogenesis and diseases. However, obtaining myoblasts from patients with neuromuscular diseases or healthy subjects poses ethical procedural challenges that limit such investigations. An alternative consists converting skin fibroblasts into myogenic cells by forcing expression regulator MYOD. Here, we directly compared cellular phenotype, transcriptome, nuclear lamina-associated...
Abstract Cytokinesis failure leads to the emergence of tetraploid cells and multiple centrosomes. Chronic lymphocytic leukaemia (CLL) is most common haematological malignancy in adults characterized by clonal B cell expansion. Here, we show that a significant number peripheral blood CLL are arrested cytokinesis this event occurred after nuclear envelope reformation before cytoplasmic abscission. mRNA expression data showed several genes known be crucial for cycle regulation, checkpoint...