A5027706921- Pharmacological Effects of Natural Compounds
- Natural product bioactivities and synthesis
- Dermatology and Skin Diseases
- Inflammatory Bowel Disease
- Helicobacter pylori-related gastroenterology studies
- IL-33, ST2, and ILC Pathways
- Inflammasome and immune disorders
- Pharmacological Effects of Medicinal Plants
- Psoriasis: Treatment and Pathogenesis
- RNA Research and Splicing
- Genomics and Chromatin Dynamics
- Cytokine Signaling Pathways and Interactions
- PI3K/AKT/mTOR signaling in cancer
- Neurological Disease Mechanisms and Treatments
- Fibroblast Growth Factor Research
- NF-κB Signaling Pathways
Shuguang Hospital
2020-2024
Shanghai University of Traditional Chinese Medicine
2020-2024
Shanghai Sunshine Rehabilitation Center
2021
Xiangyang Hospital of Traditional Chinese Medicine
2021
Abstract Oral administration of indigo naturalis (IN) can induce remission in ulcerative colitis (UC); however, the underlying mechanism remains unknown. The main active components and targets IN were obtained by searching three traditional Chinese medicine network databases such as TCMSP five Targets fishing PharmMapper. UC disease from DrugBank,combined with four GEO gene chips. IN-UC identified matching two. A protein–protein interaction was constructed, core screened according to...
Ulcerative colitis (UC) is one of the most refractory digestive diseases in world. Kui jie tong (KJT) an effective traditional Chinese medicine used clinically to treat UC. This study observed regulatory effects KJT on NIMA-related kinase 7- (NEK7-) activated nod-like receptor protein-3 (NLRP3)/caspase-1 classical pyroptosis pathway and intestinal flora UC model rats. components were analyzed using ultraperformance liquid chromatography-tandem mass spectrometer (UPLC-MS/MS). A Sprague Dawley...
Five-Flavor Sophora flavescens Enteric-Coated Capsules (FSEC) are the only proprietary Chinese medicine approved for treatment of ulcerative colitis (UC) in China. Phase II and III clinical trials have shown that curative effect FSEC relieving UC was not inferior to mesalazine granules enteric-coated tablets, but its pharmacological mechanism is unclear. Therefore, network pharmacology used reveal more comprehensive effective components targets UC.We screened based on TCMSP database,...
Colon cancer (CC) is the most frequently occurring digestive system malignancy and associated with a dismal prognosis. While super-enhancer (SE) genes have been identified as prognostic markers in several cancers, their potential practical for CC patients remains unexplored.
Qingdai (QD), derived from various plant sources, is commonly used in traditional Chinese medicine for ulcerative colitis (UC) treatment. However, the clinical efficacy and mechanisms of orally administered QD remain unclear. This study aims to evaluate QD's UC treatment uncover its active components mechanisms. A randomized controlled trial compared Adisa, followed by UPLC-Q-TOF/MS network pharmacology analyses identify core targets. In vivo experiments on a mouse model explored impact...
Abstract Background: This study aimed to explore the main components and targets of E-Lian granule through which it reversed chronic atrophic gastritis with intestinal metaplasia, based on traditional Chinese Medicine Integrated Pharmacology Network Computing Research Platform V2.0 (TCMIP V2.0) combined GEO gene chips. It also construct various networks predict analyze mechanism in treating gastric precancerous lesions. Methods: The effective medicine prescription were obtained using TCMIP...