A5002415063- Ion Channels and Receptors
- Respiratory and Cough-Related Research
- Asthma and respiratory diseases
- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- Breast Implant and Reconstruction
- Neuropeptides and Animal Physiology
- Ion channel regulation and function
- Neuroscience of respiration and sleep
- Biochemical Analysis and Sensing Techniques
- Emergency and Acute Care Studies
- Trauma and Emergency Care Studies
- Neuroscience and Neuropharmacology Research
- Pain Mechanisms and Treatments
- Vagus Nerve Stimulation Research
- Blood Coagulation and Thrombosis Mechanisms
- Radiomics and Machine Learning in Medical Imaging
- Cardiac Arrest and Resuscitation
- Multiple and Secondary Primary Cancers
- Male Breast Health Studies
- Gallbladder and Bile Duct Disorders
- Global Cancer Incidence and Screening
- Digital Radiography and Breast Imaging
- Neurobiology and Insect Physiology Research
- BRCA gene mutations in cancer
Emory University
2005-2024
Royal North Shore Hospital
2024
Northumbria Healthcare NHS Foundation Trust
2009-2021
University of British Columbia
2013-2021
GlaxoSmithKline (United States)
2006-2021
BioElectronics (United States)
2021
Emory University Hospital
2019
Harvard Affiliated Emergency Medicine Residency
2016
Newark Beth Israel Medical Center
2016
Wansbeck General Hospital
2008-2014
Inflammation contributes to pain hypersensitivity through multiple mechanisms. Among the most well characterized of these is sensitization primary nociceptive neurons by arachidonic acid metabolites such as prostaglandins G protein-coupled receptors. However, in light recent discovery that nociceptor-specific ion channel transient receptor potential A1 (TRPA1) can be activated exogenous electrophilic irritants direct covalent modification, we reasoned carbon-containing A- and J-series...
Transient receptor potential (TRP) A1 channels are cation found preferentially on nociceptive sensory neurones, including capsaicin-sensitive TRPV1-expressing vagal bronchopulmonary C-fibres, and activated by electrophilic compounds such as mustard oil cinnamaldehyde. Oxidative stress, a pathological feature of many respiratory diseases, causes the endogenous formation number reactive alkenals via lipid peroxidation. One alkenal, 4-hydroxynonenal (4HNE), activates TRPA1 in cultured neurones....
Traumatic brain injury (TBI) is a major health care concern that currently lacks any effective treatment. Despite promising outcomes from many preclinical studies, clinical evaluations have failed to identify pharmacological therapies, suggesting the translational potential of models may require improvement. Rodents continue be most widely used species for TBI research. As human TBIs result impact an intact skull, closed head (CHI) are highly relevant, however, traditional CHI suffer...
Toluene diisocyanate (TDI), a reactive, hazardous irritant, causes respiratory symptoms such as cough, rhinitis, dyspnea, and chest tightness in exposed workers. Although previous animal studies have shown that TDI reflexes are abolished by desensitization of capsaicin-sensitive sensory nerves, the specific molecular identity transducer(s) responsible for sensing this noxious stimulus has, to date, remained elusive. Recent demonstrated transient receptor potential ankyrin 1 (TRPA1), an ion...
Background Brain lipoprotein metabolism is dependent on particles that resemble plasma high‐density lipoproteins but contain apolipoprotein (apo) E rather than apoA‐I as their primary protein component. Astrocytes and microglia secrete apoE not apoA‐I; however, detectable in both cerebrospinal fluid brain tissue lysates. The route by which enters the central nervous system unknown. Methods Results Steady‐state levels of murine interstitial are 0.664 0.120 μg/ mL , respectively, whereas ≈10%...
Non‐technical summary Sodium channels are obligatory for the conduction of action potentials along axons. There several different sodium channel subtypes expressed in vagal sensory neurons, and it is difficult to pharmacologically block these selectively. We used virally delivered shRNA selectively production one namely Na V 1.7, found that by inhibiting expression this was blocked majority neurons. This study also shows 1.7 required elicitation classical reflexes such as cough.
Lung vagal sensory fibres are broadly categorized as C (nociceptors) and A (non-nociceptive; rapidly slowly adapting low-threshold stretch receptors). These afferent fibre types differ in degree of myelination, conduction velocity, neuropeptide content, sensitivity to chemical mechanical stimuli, well evoked reflex responses. Recent studies nociceptive the somatosensory system indicated that tetrodotoxin-resistant (TTX-R) voltage-gated sodium channels (VGSC) preferentially expressed (dorsal...
The Cardiac Arrest Registry to Enhance Survival (CARES) was created in 2004 collaboration with the Centers for Disease Control and Prevention (CDC) Emory University School of Medicine's Department Emergency Medicine. registry allows local communities benchmark their performance, enhance quality care, increase survival rates out-of-hospital cardiac arrest (OHCA). CARES enrolls patients who experience a non-traumatic, EMS-treated OHCA. For each case, data is collected from three sources: 911...
Traumatic brain injury (TBI) increases Alzheimer's disease (AD) risk and leads to the deposition of neurofibrillary tangles amyloid deposits similar those found in AD. Agonists Liver X receptors (LXRs), which regulate expression many genes involved lipid homeostasis inflammation, improve cognition reduce neuropathology AD mice. One pathway by LXR agonists exert their beneficial effects is through ATP-binding cassette transporter A1 (ABCA1)-mediated transport onto apolipoprotein E (apoE). To...
Concussion is a serious health concern. in athletes of particular interest with respect to the relationship concussion exposure risk chronic traumatic encephalopathy (CTE), neurodegenerative condition associated altered cognitive and psychiatric functions profound tauopathy. However, much remains be learned about factors other than cumulative that could influence pathogenesis. Approximately 20% CTE cases report history substance use including androgenic-anabolic steroids (AAS). How acute,...
G protein-coupled receptor (GPCR) kinases (GRKs) were discovered by virtue of their ability to phosphorylate activated GPCRs. They constitute a branch the AGC kinase superfamily, but mechanism activation is largely unknown. To initiate study GRK2 activation, we sought identify sites on remote from active site that are involved in interactions with substrate receptors. Using atomic structure complex Gbetagamma as guide, predicted residues surface domain face cell membrane would interact...
Proteases may act as cell signaling molecules via protease-activated receptors (PARs). PAR1, PAR3, and PAR4, but not PAR2, are activated by thrombin, whereas trypsin can activate PAR2 PAR4. In this study, (3–100 nM) evoked concentration-dependent contractions of guinea pig isolated bronchus, however, thrombin (3–300 was a weak spasmogen. Neither the PAR2-activating peptide SLIGRL (100 μ M) nor mast tryptase nM), trypsin-like protease known to contraction. A role for neurokinins in...
Myofibroblastoma of the breast is a rare benign spindle cell tumor. The main aim this study to review literature We present case mammary myofibroblastoma occurring in an 82-year-old man, emphasizing clinical, radiological, and pathological features. tumor was successfully identified managed our hospital. would like draw attention clinicians as possibility differential diagnosis mass.