CuO nanoparticles have been studied for C−N, C−O, and C−S bond formations via cross-coupling reactions of nitrogen, oxygen, sulfur nucleophiles with aryl halides. Amides, amines, imidazoles, phenols, alcohols thiols undergo iodides in the presence a base such as KOH, Cs2CO3, K2CO3 at moderate temperature. The procedure is simple, general, ligand-free, efficient to afford cross-coupled products high yield.

Cheap but good: Readily available CuO nanoparticles are not only less expensive than other catalysts used for the CS cross-coupling of thiols with aryl halides, they also effective at a moderate temperature and low concentration. The title reaction proceeds variety alkyl to give corresponding sulfides in high yields (see scheme). Supporting information this article is on WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z701282_s.pdf or from author. Please note: publisher responsible...

Using a prototypical Diels-Alder reaction as benchmark, we show that dicationic halogen-bond donors are capable of activating neutral organic substrate. By various comparison experiments, the action traces acid or other structural features donor not related to halogen bonding excluded with high certainty.

CuO nanoparticles catalyze the C−N cross coupling of amines with iodobenzene in excellent yields. The reaction is simple and efficient operates under air ligand free conditions. catalyst recyclable without loss activity.

We have conducted isothermal calorimetric titrations to investigate the halogen-bond strength of cationic bidentate donors toward halides, using bis(iodoimidazolium) compounds as probes. These data are intended aid rational design well development halogen-bond-based applications in solution. In all cases examined, entropic contribution overall free energy binding was found be very important. The affinities showed little dependency on weakly coordinating counteranions but became slightly...

Bi- and tridentate polycationic halogen bond donors based on 5-iodo-1,2,3-triazolium groups have been synthesized by 1,3-dipolar cycloaddition reactions. These halogen-based Lewis acids evaluated as activators in a halide-abstraction benchmark reaction.

Abstract CuI efficiently catalyzes the C–S cross coupling of thiols with aryl halides in presence tetrabutylammonium bromide water. The reactions that have electron‐withdrawing and ‐donating substituents are comparable afford cross‐coupling products high yield. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)

Face-to-face: Allene carboxylates can serve as efficient dipolarophiles for Rh-catalyzed carbonyl ylide cycloadditions (see scheme). The endo and exo products arise from cycloaddition on the same face of allene, but opposite faces dipole. This facial selectivity results in formation two four possible diastereomers.

Sulfur based tetrahydro-isoquinoline are rarely accessible in literature but its synthesis is attractive due to importance medicinal chemistry and pharmaceutical industry. A very first example of thio-cotarnine derivatives...

Abstract The cross‐aldol reaction between enolizable aldehydes and α‐ketophosphonates was achieved for the first time by using 9‐amino‐9‐deoxy‐ epi ‐quinine as catalyst. β‐Formyl‐α‐hydroxyphosphonates were obtained in high to excellent enantioselectivities. works especially well with acetaldehyde, which is a tough substrate organocatalyzed reactions. products demonstrated have anticancer activities.

Simple addition: Copper(II) aqua complex 1 can be prepared in a one-pot synthesis and is self-assembled by H-bond interactions. Complex shown to accelerate the nitroaldol reaction on water, which heterogeneous process, requiring no additive or base, recycled without loss of activity. has been synthesis. The single crystal X-ray analysis showed that through ligands interactions copper(II) atoms are pentacoordinated with square pyramidal geometry. studied for acceleration nitroalodol water. It...

Attraktiv und preiswert: Leicht erhältliche CuO-Nanopartikel kosten nicht nur weniger als andere Katalysatoren für die C-S-Kreuzkupplung, sie sind überdies schon bei moderaten Temperaturen geringen Konzentrationen aktiv. Die Titelreaktion führt mit zahlreichen Alkyl- Arylthiolen in hohen Ausbeuten zu den entsprechenden Sulfiden (siehe Schema).

Abstract The oxidation of alcohols to aldehydes and ketones has been described using silica‐supported vanadium( IV ) oxide (V/SiO 2 , 1 in the presence tert ‐butyl hydroperoxide tert‐ butyl alcohol at ambient temperature with quantitative yields. procedure is simple, efficient environmentally benign.

Abstract A recyclable silica supported vanadium 1 catalyzes the oxidation of tertiray amines to corresponding N ‐oxides with 30% H 2 O in high yield.

Abstract Cadmium diacetate dihydrate [Cd(OAc) 2 ⋅2 H O] in combination with ethylene glycol catalyzes efficiently the CN cross‐coupling of amines aryl iodides by a benzyne mechanism. Alkyl, and heterocyclic are compatible this system affording aminated products high to excellent yield.

Chiral copper(II) coordination polymers 1a−c have been prepared by one-pot synthesis in high yield. Their single-crystal X-ray analysis showed that repeating units are connected to each other carboxylate linker and atoms pentacoordinated with distorted square-pyramidal geometry for 1a−b square-planar 1c. These catalyzed the kinetic resolution of secondary alcohols acylation up 90% ee (s = 50).

Although halogen bonds share many similarities with hydrogen bonds, they have so far found virtually no application in organic synthesis. This account summarizes our efforts to use multidentate halogen-bond donors (halogen-based Lewis acids) formal halide abstraction reactions. Following a first proof-of-principle study, we recently reported the halogen-bond-based organocatalytic carbon–carbon bond-forming reaction.