CuO nanoparticles have been studied for C−N, C−O, and C−S bond formations via cross-coupling reactions of nitrogen, oxygen, sulfur nucleophiles with aryl halides. Amides, amines, imidazoles, phenols, alcohols thiols undergo iodides in the presence a base such as KOH, Cs2CO3, K2CO3 at moderate temperature. The procedure is simple, general, ligand-free, efficient to afford cross-coupled products high yield.

The synthesis of substituted benzimidazoles, 2-aminobenzimidazoles, 2-aminobenzothiazoles, and benzoxazoles is described via intramolecular cyclization o-bromoaryl derivatives using copper(II) oxide nanoparticles in DMSO under air. procedure experimentally simple, general, efficient, free from addition external chelating ligands. It a heterogeneous process the can be recovered recycled without loss activity.

Cheap but good: Readily available CuO nanoparticles are not only less expensive than other catalysts used for the CS cross-coupling of thiols with aryl halides, they also effective at a moderate temperature and low concentration. The title reaction proceeds variety alkyl to give corresponding sulfides in high yields (see scheme). Supporting information this article is on WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z701282_s.pdf or from author. Please note: publisher responsible...

CuO nanoparticles catalyze the C−N cross coupling of amines with iodobenzene in excellent yields. The reaction is simple and efficient operates under air ligand free conditions. catalyst recyclable without loss activity.

[reaction: see text] Oxidation of alcohols to aldehydes and ketones has been studied in high yields using atmospheric oxygen a catalytic amount V2O5 toluene under heating (ca. 100 degrees C). Secondary can be chemoselectively converted into the presence primary hydroxy groups.

The oxidative C-H amination of N"-aryl-N'-tosyl/N'-methylsulfonylamidines and N,N'-bis(aryl)amidines has been accomplished using iodobenzene as a catalyst to furnish 1,2-disubstituted benzimidazoles in the presence mCPBA terminal oxidant at room temperature. reaction is general, target products can be obtained moderate high yields.

C7-Decorated indoles are important structural motifs present in a plethora of bioactive and pharmaceutical compounds. Early stage developments for C7 modifications were realized through directed metallation (DOM) subsequent quenching with suitable electrophiles or by halogenation Cu(ii) halides. Direct C-7 functionalization is comparatively difficult compared to at C-2 C-3 positions owing the inherent reactivity pyrrole-type ring. However, recently transition-metal-catalyzed auxiliary...

Cobalt(II)-complex catalyzes efficiently the intramolecular C–N and C–O cross-couplings of Z-N′-(2-halophenyl)-N-phenylamidines N-(2-bromophenyl)benzamides to afford corresponding substituted benzimidazoles benzoxazoles in presence K2CO3 at moderate temperature. The protocol is general, air stable affords products selectively high yield.

An efficient method for the transformation of N-benzyl bisarylhydrazones and bisaryloxime ethers to functionalized 2-aryl-N-benzylbenzimidazoles 2-arylbenzoxazoles is described. The protocol involves a copper(II)-mediated cascade C-H functionalization/C-N/C-O bond formation under neutral conditions. Substrates having either electron-donating or -withdrawing substituents undergo cyclization afford target heterocycles at moderate temperature.

An unprecedented copper(II)-catalyzed aerobic oxidative synthesis of 2,4,5-triaryl-1,2,3-triazoles and 1,3,5-triaryl-1,2,4-triazoles from bisarylhydrazones as the common starting precursor has been achieved via cascade C–H functionalization/C–C/N–N/C–N bonds formation under mild reaction conditions. One enthralling outcomes this strategy is room temperature functionalization/C–N bond in presence air, which accomplished during substituted 1,2,4-triazoles. This new class compounds could give...

A novel and efficient copper-catalyzed amination of N-aryl imines is described. This one-pot, multicomponent reaction, in which imine acts as a directing group by chelating to the metal center, affords potential route for transformation commercial aryl amines, aldehydes, azides into valuable benzimidazole structural units with wide substrate scope diversity. The synthetic mechanistic aspects are presented.

Heterocyclic alkenes and their derivatives are an important class of reactive feedstock valuable synthons. This review highlights the transition-metal-catalyzed coupling heterocyclic alkenes<italic>via</italic>a C–H functionalization strategy.

Abstract CuI efficiently catalyzes the C–S cross coupling of thiols with aryl halides in presence tetrabutylammonium bromide water. The reactions that have electron‐withdrawing and ‐donating substituents are comparable afford cross‐coupling products high yield. (© Wiley‐VCH Verlag GmbH &amp; Co. KGaA, 69451 Weinheim, Germany, 2008)

Oxidation of alcohols to aldehydes and ketones has been studied in high yields using molecular oxygen a catalytic amount 1 toluene under stirring (ca. 100 °C). The reactions primary are faster compared secondary the catalyst can be recycled without loss activity.

Abstract The palladium‐catalyzed one‐pot conversion of aldehydes into primary amides in the presence hydroxylamine hydrochloride aqueous dimethyl sulfoxide (DMSO) at moderate temperature is described. process selective and free from addition an external chelating ligand.

In suspension: The reaction of aziridines with heterocumulenes in the presence Fe(NO3)3⋅9 H2O aqueous suspension provides access to functionalized five-membered heterocycles good high yields. This protocol has a wide substrate scope, is simple, and uses nontoxic cheap catalyst. As service our authors readers, this journal supporting information supplied by authors. Such materials are peer reviewed may be re-organized for online delivery, but not copy-edited or typeset. Technical support...

A copper(II)-catalyzed conversion of bisaryloxime ethers to 2-arylbenzoxazoles has been developed. The reaction involves a cascade C-H functionalization and C-N/C-O bond formation under oxygen atmosphere.

Copper(II)-catalyzed oxidative cross-coupling of anilines, primary alkyl amines, and sodium azide is described in the presence TBHP at moderate temperature. This one-pot multicomponent protocol involves a domino C-H functionalization, transimination, ortho-selective amination, cyclization sequence. The broad substrate scope functional group compatibility are significant practical features. can be extended to coupling benzyl alcohols with yields.

Copper(II)-catalyzed direct dioxygenation of alkenes using air and a simple N-hydroxyphthalimide leading to β-keto-N-alkoxyphthalimides has been developed. The reaction system is mild, efficient, effective at room temperature with broad substrate scope substantial steric hindrance. radical-trapping 18O-labeling experiments have demonstrated.

An organocatalytic protocol for the syntheses of 2-substituted benzoxazoles and benzothiazoles is described from alkyl-/arylanilides alkyl-/arylthioanilides using 1-iodo-4-nitrobenzene as catalyst oxone an inexpensive environmentally safe terminal oxidant at room temperature in air via oxidative C–H functionalization C–O/S bond formation. The procedure simple general provides effective route construction functionalized 2-alkyl-/arylbenzoxazoles 2-alkyl-/arylbenzothiazoles with moderate to...

A weak carbonyl coordination facilitated tunable reactivity between alkenylation and alkylation of indoles at the C4 C-H site is presented using readily accessible allylic alcohols in presence Rh catalysis by switching additives or directing group. Exclusive selectivity, functional group tolerance, late-stage modifications are important practical features.