The synthesis of substituted benzimidazoles, 2-aminobenzimidazoles, 2-aminobenzothiazoles, and benzoxazoles is described via intramolecular cyclization o-bromoaryl derivatives using copper(II) oxide nanoparticles in DMSO under air. procedure experimentally simple, general, efficient, free from addition external chelating ligands. It a heterogeneous process the can be recovered recycled without loss activity.

One-pot synthesis of 2-(arylthio)arylcyanamides is accomplished using cheap and air-stable CuSO(4) x 5 H(2)O as a catalyst by domino intra- intermolecular C-S cross-coupling reactions 2-(iodoaryl)thioureas with aryl iodides under ligand-free conditions.

Multicomponent reaction: 2-Azido-1-substituted-1H-benzo[d]imidazoles were prepared using a copper-catalyzed three-component reaction involving 2-bromoaniline derivatives, isothiocyanates, and sodium azide. The conditions mild the scope was broad. azido compounds transformed into their 2-amino 2-triazolyl derivatives copper-mediated reduction cycloaddition, respectively (see scheme).

Substituted 2-aminophenyl benzothiazoles have been constructed from thiourea <italic>via</italic> copper-catalyzed desulfurization/nucleophilic substitution followed by domino intra- and intermolecular C–N cross-coupling reactions under moderate reaction conditions.

A facile, one-pot, and proficient method was developed for the production of various 2-arylaminobenzimidazoles. This methodology is based first time on a copper catalyst promoted domino C–N cross-coupling reaction generation Mechanistic investigations revealed that synthetic pathway involves copper-based desulphurization/nucleophilic substitution subsequent intra intermolecular reactions. Some issues typically encountered during synthesis 2-arylaminobezimidazoles, including use expensive...

Abstract The synthesis of 2‐aminobenzothiazoles has been demonstrated in the presence transition metal under mild reaction conditions. In this paper, disubstituted thioureas have also reported from isothiocyanates at room temperature. Subsequently, C−S cross‐coupling was described for construction benzothiazoles using cheap, readily available and air stable Iron catalyst. Moreover, no other byproducts could be observed except target products. Furthermore, control experiments were performed...

We have developed methodology for the synthesis of aryl/alkyl cyanamides from amines in one-pot four steps reaction using cheap, readily available and air stable copper source as catalyst under mild conditions. also studied application cyanamides. In this connection, we could construct aryl tetrazolamine click

Abstract A facile, efficient, and simple one‐pot multi‐component protocol for the synthesis of pyrano[2,3‐c] pyrazoles has been developed using a cheap readily available copper catalyst under moderate reaction conditions. Target products are obtained from aromatic aldehyde via Knoevenagel condensation Michael addition reactions. Functional group tolerance mechanisms have also examined in this methodology. In addition, we evaluated anti‐cancer activity target attempted method practical...

Consecutive addition/domino C–S cross-coupling reaction has been developed for the synthesis of 2-arylthio arylcyanamides.

Abstract Domino C–Se cross‐coupling of 2‐(iodoaryl)selenoureas with aryl iodides has been accomplished in the presence a copper(I)–1,1‐phenanthroline complex at moderate temperature. The reactions involve intra‐ and intermolecular to give substituted 2‐(arylselanyl)arylcyanamides. Aryl having electron‐donating ‐withdrawing substituents are compatible, affording targetselanyl ethers high yield.

Abstract Efficient, simple and multi component methodology has been demonstrated for the construction of l‐Aryl/Alkyl‐5‐( N ‐Benzoylamino) tetrazoles guanidine's. These compounds can be used as intermediates synthesis heterocyclic such substituted 2‐( N‐ benzoyl) benzimidazoles fused cyclic tetrazoles. Target products were obtained from benzyol chloride via in situ consecutive formation benzoyl isothiocyanates aryl thiourea. Moreover, desulphurization was also observed during this...

Abstract We have constructed a new library of 1,2,3‐triazole tethered pyrazole derivatives ( 6 – h &amp; 7 ) from propargyl alcohol through simultaneous click process, oxidation, condensation, and rearrangement under mild reaction conditions. The final products were obtained in moderate to good yields. All the compound structures characterized by analytical spectral 1 H NMR, 13 C NMR HRMS) studies. Furthermore, evaluation biological activity newly synthesized molecules was done against three...

Abstract: Environmentally benign syntheses of One-pot sequential reactions benzoyl chloride with amines followed by the treatment molecular I2 reagent under basic conditions provide tetrazoles and guanidines in moderate to excellent yields. This one-pot synthesis has several advantages such as mild reaction conditions, short time, convenient workup, high yields, using cheap readily available Iodine. In addition, functional group tolerance been explored.

A general and efficient multi-component reaction has been established for the construction of 5-amino tetrazoles guanidines under mild conditions. All substrates are readily carried out optimized conditions to provide their respective target products in good excellent yields. The regioselectivity is also explained this manuscript. Further, method free, uses water as a green solvent, practical (at room temperature an open atmosphere). In addition, we could not identify any other during...