The first highly diastereo- and enantioselective synthesis of bridged O,O-acetals embedded with spirooxindoles has been developed. Dioxindoles 2-hydroxy cinnamaldehydes were employed as the reaction partners in this method. desired products obtained via diaryl prolinol TBS ether catalyzed Michael followed by acetal formation TFA.

The first organocatalytic enantioselective synthesis of dihydrofuran-spirooxindoles having a linkage at the 2-position dihydrofuran motif has been developed. Dioxindoles and benzylidene malononitriles were employed in this method. desired spirooxindole products obtained via Michael reaction followed by Pinner isomerization good to high yields with moderate diastereo enantioselectivities observed.

Abstract An efficient organocatalytic asymmetric synthesis of 2,3,4‐trisubstituted tetrahydrofurans and tetrahydropyrans has been developed using tandem iminium−enamine catalysis. The process comprises a double Michael addition reaction between γ/δ‐hydroxy‐α,β‐unsaturated carbonyls enals. products this are obtained in high enantio‐ diasteroselectivities some further synthetic transformations have performed.

The first highly enantioselective organocatalytic reaction employing 2-hydroxyacetophenones is disclosed, namely Michael-hemiacetalization of with enals. combination a primary amine and secondary catalyst was found to be the best choice for this methodology. products were obtained in high enantio- diastereoselectivities converted variety biologically important γ-butyrolactones.

The first organocatalytic enantioselective synthesis of bridged O,O ‐ketals embedded with spirooxindoles has been developed. Dioxindoles and ortho ‐hydroxy‐benzylidene acetones were engaged as the reaction partners in this method. desired products obtained via epi ‐cinchonine primary amine catalyzed Michael followed by ketal formation TFA.

The first organocatalytic asymmetric synthesis of spiro-dihydropyrano cyclohexanones has been developed <italic>via</italic> the cascade reaction between cyanoketones and cyclic 2,4-dienones.

Abstract We have constructed a new library of 1,2,3‐triazole tethered pyrazole derivatives ( 6 – h &amp; 7 ) from propargyl alcohol through simultaneous click process, oxidation, condensation, and rearrangement under mild reaction conditions. The final products were obtained in moderate to good yields. All the compound structures characterized by analytical spectral 1 H NMR, 13 C NMR HRMS) studies. Furthermore, evaluation biological activity newly synthesized molecules was done against three...

Abstract An efficient temperature control C−S and C−N bond formation under mild nickel‐catalysed domino cross‐coupling conditions is described. The advantages of this approach are good functional group compatibility, cheaper nickel catalyst, use base. In addition, to the best our knowledge methodology first successful example synthesis 2‐Arylsulfonyl Aryl cyanamides 2‐Aminophenyl Benzothiazole.

Abstract This review article summarizes the recent developments of organocatalytic asymmetric ene reactions. Ene reaction is one most useful methods for formation C−C bonds in organic synthesis. After development 1943 by Kurt Alder, this was thoroughly studied, and various catalytic reports were published. an updated on

Abstract An organocatalytic enantioselective synthesis of dihydrofuran‐spirooxindoles has been developed. Dioxindoles and trans ‐α‐cyano‐α,β‐unsaturated ketones were engaged as the reaction partners in this method. The desired products obtained via bifunctional squaramide catalyzed Michael followed by Pinner isomerization.