A5090957125- Antimicrobial agents and applications
- Biopolymer Synthesis and Applications
- Environmental Chemistry and Analysis
- Bacterial biofilms and quorum sensing
- Fungal and yeast genetics research
- Surfactants and Colloidal Systems
- Microbial Metabolic Engineering and Bioproduction
- ATP Synthase and ATPases Research
- Fermentation and Sensory Analysis
- Phenothiazines and Benzothiazines Synthesis and Activities
- Food Quality and Safety Studies
- Protein Structure and Dynamics
- Antibiotic Resistance in Bacteria
- Metalloenzymes and iron-sulfur proteins
- Pharmaceutical and Antibiotic Environmental Impacts
- Agriculture, Plant Science, Crop Management
- Metal complexes synthesis and properties
- Amino Acid Enzymes and Metabolism
- Pesticide and Herbicide Environmental Studies
- RNA Interference and Gene Delivery
- Antifungal resistance and susceptibility
- Polyamine Metabolism and Applications
- Synthesis and Reactions of Organic Compounds
- Organic Chemistry Synthesis Methods
- Medical and Biological Ozone Research
University of Wrocław
2010-2024
University of Zielona Góra
2002
Abstract Newly synthesized gemini quaternary ammonium salts (QAS) with different counterions (bromide, hydrogen chloride, methylcarbonate, acetate, lactate), chain lengths (C12, C14, C16) and methylene linker (3xCH 2 ) were tested. Dihydrochlorides dibromides 12 carbon atoms in hydrophobic chains characterized by the highest biological activity against planktonic forms of yeast yeast-like fungi. The tested surfactants also inhibited production filaments C. albicans . Moreover, they reduced...
The antibacterial activity of alanine-derived gemini quaternary ammonium salts (chlorides and bromides) with various spacer alkyl chain lengths was investigated. studied compounds exhibited a strong bactericidal effect, especially bromides 10 12 carbon chains 3 groups (TMPAL-10 Br TMPAL-12 Br), short contact time. Both dislodged biofilms Pseudomonas aeruginosa Staphylococcus epidermidis, were lethal to adherent cells S. epidermidis. Bromide 2 (TMEAL-12 Br) effectively reduced microbial...
Quaternary ammonium salts (QAS) commonly occur as active substances in disinfectants. QAS have the important property of coating abiotic surfaces, which prevents adhesion microorganisms, thus inhibiting biofilm formation. In this study, a group nine monomeric QAS, differing structure and length aliphatic chain (C12, C14, C16) counterion (methylcarbonate, acetate, bromide), were investigated. The study included an analysis their action against planktonic forms well bacterial biofilms....
A group of biodegradable alanine-derived gemini quaternary ammonium salts (bromides and chlorides) with various alkyl chains spacer lengths was tested for anti-adhesive anti-biofilm activity. The strongest antifungal activity exhibited by bromides 10 12 carbon atoms within hydrophobic (N,N'-bis(1-decyloxy-1-oxopronan-2-yl)-N,N,N',N'-tetramethylpropane-1,3-diammonium dibromide N,N'-bis(1-dodecyloxy-1-oxopronan-2-yl)-N,N,N',N'-tetramethylethane-1,2-diammonium dibromide). It also demonstrated...
Our research aims to expand the knowledge on relationships between structure of cationic dicephalic surfactants-N,N-bis[3,3_-(dimethylamine)propyl]alkylamide dihydrochlorides and N,N-bis[3,3_-(trimethylammonio)propyl]alkylamide dibromides (alkyl: n-C9H19, n-C11H23, n-C13H27, n-C15H31)-and their antifungal mechanism action Candida albicans. The mentioned groups amphiphilic substances are characterized by presence a weak, hydrochloride center readily undergoing deprotonation, as well stable,...
The studies were aimed to contribute the elucidation of relationships between structure double-headed cationic surfactants-N,N-bis[3,3'-(dimethylamine)- propyl]alkylamide dihydrochlorides and N,N-bis[3,3'-(trimethylammonio)propyl]alkylamide dibromides (alkyl: n-C9 H19 , n-C11 H23 n-C13 H27 n-C15 H31 ) their antibacterial biofilm preventing activity.The minimal inhibitory bactericidal concentrations (MIC MBC) dicephalic surfactants against Staphylococcus epidermidis Pseudomonas aeruginosa...
Quaternary ammonium salts (QASs) are commonly used in medicine, agriculture and industry their wide usage caused the development of microbial resistance, thus there is still a need for new effective antimicrobial agents. Present work describes biological activity alanine- (DMALM-n) glycine-derived (DMGM-n) QASs against planktonic biofilm forms micro-organisms. The was dependent mainly on hydrocarbon chain length surfactants with 12-16 atoms carbon alkyl were most active ones. lowest MIC...
Abstract We investigated the action of quaternary ammonium salt (QAS) called IM (N-(dodecyloxycarboxymethyl)-N,N,N-trimethyl chloride) on Saccharomyces cerevisiae yeast cells. Changes in cell ultrastructure were confirmed by electron microscopy. treated resistant mutant cells with QAS, and destruction cytoplasm, an increase thickness wall, separation wall from accumulation numerous lipid droplets. also observed a relatively high production lipids parental wild-type strain Σ1278b its...
Multidrug resistance is a major problem in the treatment of infectious diseases caused by bacteria and fungi. One basic mechanisms active efflux distinct drugs from cells. Export toxic compounds bacterial cells mediated proteins 5 families: MF, SMR, ABC, RND MATE. The substrate spectrum pumps includes antibiotics, chemotherapeutics detergents. Genes that determine can be located on chromosomes or mobile elements (plasmids, transposons, integrons). presence genes enables to transfer those...