A5044190247- Synthesis and biological activity
- Multicomponent Synthesis of Heterocycles
- Cholinesterase and Neurodegenerative Diseases
- Computational Drug Discovery Methods
- Synthesis of Organic Compounds
- Synthesis and Biological Evaluation
- Synthesis and Characterization of Heterocyclic Compounds
- Click Chemistry and Applications
- Essential Oils and Antimicrobial Activity
- Natural product bioactivities and synthesis
- Nanomaterials for catalytic reactions
- Advanced Photocatalysis Techniques
- Phytochemistry and Biological Activities
- Pharmacological Effects of Natural Compounds
- Advanced oxidation water treatment
- Synthesis of heterocyclic compounds
- Metal-Organic Frameworks: Synthesis and Applications
- Natural Antidiabetic Agents Studies
- Microwave-Assisted Synthesis and Applications
- Copper-based nanomaterials and applications
- Bioactive Compounds and Antitumor Agents
- Chemical Synthesis and Reactions
- Synthesis of Tetrazole Derivatives
- Helicobacter pylori-related gastroenterology studies
- Quinazolinone synthesis and applications
Kerman University of Medical Sciences
2016-2025
Stempeutics (India)
2018
Institute of Genetic and Biomedical Research
2017
University of Tehran
2008-2015
Islamic Azad University, Arak
2015
Abstract Acetylcholinesterase (AChE) catalyzes the conversion of Aβ peptide to its aggregated form and peripheral anionic site (PAS) AChE is mainly involved in this phenomenon. Also catalytic active (CAS) donepezil stimulates break-down acetylcholine (ACh) depletion ACh cholinergic synapses are well established brains patients with AD. In study, a set compounds bearing phenoxyethyl amines were synthesized their inhibitory activity toward electric eel (eeAChE) equine butyrylcholinesterase...
Background: Antibiotics such as ciprofloxacin (CIP) are even more important in bacterial resistance, at low concentrations. The aim of this research was to synthesize CuFe2 O4 @methylcellulose (MC) a new nano-photocatalyst for degradation CIP from aqueous solution. Methods: (CuFe2 @MC) characterized by FESEM, energy dispersive spectroscopy (EDS), X-ray diffraction (XRD) and Fourier transform infrared (FTIR), thermogravimetric analysis (TGA), vibrating sample magnetometer (VSM). Powder XRD...
This study aimed to synthesize a ZnFe2O4@carboxymethyl cellulose (CMC) nanophotocatalyst using simple, facile, and green hydrothermal method for ciprofloxacin (CIP) removal from aqueous solutions. At first, ZnFe2O4@CMC was synthesized the method, then it characterized. To assay photocatalytic activity of ZnFe2O4@CMC, its ability investigated in CIP total organic carbon (TOC) by considering effect some variables such as initial concentrations (5–30 mg/L), pH (3–11), loading (0.1–0.5 g),...
Recently widespread usage of cephalosporin antibiotics in medical and veterinary fields has received growing attentions as severe contaminants aquatic ecosystems.Since there is no report on the removal cefazolin (CFZ) using electrocoagulation adsorption (EC/AD) coupling treatment process, present work deals with efficient CFZ from hospital wastewater EC/AD process.To achieve optimal condition, response surface methodology (RSM) was applied successfully efficiency 100% under operating...
Aim: A series of 2-benzylidene-benzofuran-3-ones were designed from the structures Ebselen analogs and aurone derivatives synthesized in good yields. Materials & methods: The target compounds prepared by condensation reaction between appropriate benzofuranones with amino alkoxy aldehydes evaluated as cholinesterase inhibitors Ellman's method. Results: vitro anti-acetylcholinesterase (AChE)/butyrylcholinesterase activities revealed that 7e (IC50 = 0.045 μM) is most active compound against...
Leishmaniasis is a parasitic disease caused by protozoan organisms belonging to the Leishmania genus, affecting many individuals worldwide, with burden surpassing one million cases. This leads considerable morbidity and mortality, predominantly within tropical subtropical regions. The current therapeutic options for leishmaniasis are far from ideal, as they fail achieve level of efficacy that can be deemed universally effective. primary drawbacks existing treatments include severe side...
Metal-organic frameworks (MOFs) are structures made up of inorganic nodes, which can be either single ions or clusters and organic linkers. This study reports on a novel processing route for producing β-estradiol encapsulated in Zn-MOF nanocomposites by microwave-assisted coprecipitation as facile fast method. were synthesized with the aid Zn(OAc)2⋅2H2O 2,6-pyridine dicarboxylic acid ammonium an ligand. Furthermore, we studied is one most important classes estrogenic compounds that used...
Microbial desalination cell (MDC) is a new method of desalination. Its energy supplied through microbial metabolism organic materials. In this study, synthetic samples were provided with concentration 25, 50, 75, 100 mg/L Ni and Pb. Removal efficiency each metal was analyzed after 60, 90, 120 min, psychrophilic, mesophilic, thermophilic 3–4, 4–5, 5–6 dissolved oxygen. Optimum conditions for removing Pb achieved in 100, 4.5 4.6 oxygen, respectively, 26 °C min. Nickel led removed from...
In the present study, response surface methodology was employed to investigate effects of main variables, including initial MB concentration, hydrogen peroxide dosage, current density, and electrolysis time on removal efficiency using electro-Fenton (EF) process. The concentration determination by UV-VIS spectrometer. EF process degrades contaminant molecules highly oxidizing species •OH. A quadratic regression model developed predict MB, where R2 value found be 0.9970, which indicates...
A series of novel benzo[ d ]oxazole derivatives ( 6a–n ) have been synthesized and biologically evaluated as potential inhibitors acetylcholinesterases AC hE) butyrylcholinesterase BC hE). The chemical structures all final compounds were confirmed by spectroscopic methods. In vitro studies showed that most the are potent acetylcholinesterase inhibitors. Among them, 6a 6j strongly inhibited hE activities with IC 50 values 1.03–1.35 6.6–8.1 μ m , respectively. Docking also provided binding...
A new series of indole-carbohydrazide-phenoxy-1,2,3-triazole-N-phenylacetamide hybrids 11a-o was designed based on molecular hybridization the active pharmacophores potent α-glucosidase inhibitors. These compounds were synthesized and evaluated against α-glucosidase.The 15 various derivatives scaffold synthesized, purified, fully characterized. yeast in vitro silico. ADMET properties most also predicted.All (IC50 values = 6.31 ± 0.03-49.89 0.09 µM) are excellent inhibitors comparison to...