A5020954018- Peripheral Artery Disease Management
- Renal and Vascular Pathologies
- Vascular Procedures and Complications
- Cerebrovascular and Carotid Artery Diseases
- Venous Thromboembolism Diagnosis and Management
- Cardiovascular Health and Disease Prevention
- Acute Ischemic Stroke Management
- Central Venous Catheters and Hemodialysis
- Coronary Interventions and Diagnostics
- Diagnosis and Treatment of Venous Diseases
- Immune Cell Function and Interaction
- Atrial Fibrillation Management and Outcomes
- Health Systems, Economic Evaluations, Quality of Life
- T-cell and B-cell Immunology
- Vascular anomalies and interventions
- Sodium Intake and Health
- Immunotherapy and Immune Responses
- Blood Pressure and Hypertension Studies
- Hormonal Regulation and Hypertension
- Congenital heart defects research
- Acute Myocardial Infarction Research
- Genetics and Neurodevelopmental Disorders
- Ultrasound in Clinical Applications
- Salivary Gland Disorders and Functions
- Endoplasmic Reticulum Stress and Disease
Beth Israel Deaconess Medical Center
2019-2025
Harvard University
2019-2025
Deaconess Hospital
2019-2024
Beth Israel Deaconess Hospital
2020-2024
Brigham and Women's Hospital
2017-2024
United States Food and Drug Administration
2024
Stanford University
2013-2020
University of California, San Francisco
2013
Macalester College
2009
City College of San Francisco
2008
Thymic epithelial cells in the medulla (mTECs) play a critical role enforcing central tolerance through expression and presentation of tissue-specific antigens (TSAs) deletion autoreactive thymocytes. TSA requires autoimmune regulator (Aire), transcriptional activator present subset mTECs characterized by high CD80 major histocompatibility complex II lack potential for differentiation or proliferation. Here, using an Aire-DTR transgenic line, we show that short-term ablation specifically...
Outpatient management of select patients with low-risk acute pulmonary embolism (PE) has been proven to be safe and effective, yet recent evidence suggests that are still managed hospitalization. Few studies have assessed contemporary real-world trends in discharge rates from U.S. emergency departments (EDs) for PE.
Abstract Mutations in the Aire gene result a clinical phenomenon known as Autoimmune Polyglandular Syndrome (APS) Type I, which classically manifests triad of adrenal insufficiency, hypoparathyroidism, and chronic mucocutaneous infections. In addition to this triad, number other autoimmune diseases have been observed APS1 patients including Sjögren’s syndrome, vitiligo, alopecia, uveitis, others. Aire-deficient mice, animal model for APS1, highlighted role thymus disease process...
Black adults have a higher incidence of peripheral artery disease and limb amputations than White in the United States. Given that endovascular intervention (PVI) is now primary revascularization strategy for disease, it important to understand whether racial differences exist PVI outcomes.Data from fee-for-service Medicare beneficiaries ≥66 years age 2016 2018 were evaluated determine age- sex-standardized population-level incidences femoropopliteal among over 3-year study period. Patients'...
While the presence of gender disparities in cardiovascular disease have been described, there is a paucity data regarding impact sex acute pulmonary embolism (PE). We identified all patients admitted to tertiary care hospital with PE between August 1, 2012 through July 2018. stratified presenting characteristics, management, and outcomes women men. Of 2031 PE, 1081 (53.2%) were women. Women more likely present dyspnea (59.8% vs 52.0%, p < 0.001) less hemoptysis (1.9% 4.0%, = 0.01). older...
The use of atherectomy during peripheral endovascular interventions (PVI) has increased dramatically, but data regarding its safety and effectiveness are lacking. Aims: This study sought to determine the long-term in contemporary practice. Methods: Medicare fee-for-service beneficiaries who underwent femoropopliteal artery PVI from 2015-2018 were identified a 100% sample inpatient, outpatient, carrier file using procedural claims codes. primary exposure was atherectomy. Inverse probability...
Importance Inferior vena cava filters (IVCFs) are commonly used to prevent pulmonary embolism in selected clinical scenarios, despite limited evidence support their use. Current recommendations from professional societies and the US Food Drug Administration endorse timely IVCF retrieval when clinically feasible. treatment patterns outcomes remain poorly described. Objectives To evaluate temporal trends practice insertion among older patients report incidence of periprocedural long-term...