A5005042752- Urinary Bladder and Prostate Research
- Pelvic floor disorders treatments
- Urological Disorders and Treatments
- Ion Channels and Receptors
- Prostate Cancer Diagnosis and Treatment
- Pediatric Urology and Nephrology Studies
- Herbal Medicine Research Studies
- Health Systems, Economic Evaluations, Quality of Life
- Kidney Stones and Urolithiasis Treatments
- Urinary Tract Infections Management
- Hormonal Regulation and Hypertension
- Ion channel regulation and function
- Aldose Reductase and Taurine
- Ureteral procedures and complications
- Bladder and Urothelial Cancer Treatments
- Circadian rhythm and melatonin
- Acute Myeloid Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Sperm and Testicular Function
- Dermatology and Skin Diseases
- Reproductive Biology and Fertility
- Neuroscience of respiration and sleep
- Advanced Glycation End Products research
- Urologic and reproductive health conditions
- Sexual Differentiation and Disorders
KU Leuven
2014-2023
Universitair Ziekenhuis Leuven
2013-2021
AZ Maria Middelares
2020
Improvement of bladder emptying by modulating afferent nerve activity is an attractive therapeutic strategy for detrusor underactivity. Transient receptor potential vanilloid 4 (TRPV4) a sensory ion channel in urothelial cells that contribute to the detection filling.To investigate benefit intravesical TRPV4 agonists pelvic injury rat model underactivity.Female wild-type and Trpv4 knockout rats underwent sham surgery or bilateral (bPNI). Four weeks later, cystometry with infusion agonist...
Acute exposure of part the skin to cold stimuli can evoke urinary urgency, a phenomenon termed acute cold-induced urgency (ACIU). Despite its high prevalence, particularly in patients with overactive bladder, little is known about mechanisms that induce ACIU. To develop an animal model ACIU and test involvement cold-activated ion channels transient receptor potential (TRP) M8 TRPA1. Intravesical pressure micturition were monitored female mice (wild-type C57BL/6J, Trpa1−/−, Trpm8+/+,...
Objectives To create a rat model for neurogenic detrusor underactivity ( DU ) by bilateral pelvic nerve crush injury BPNI and to study temporal changes in contractility morphology. Materials Methods Male Sprague‐Dawley rats were subjected or sham surgery evaluated at 1, 3 9 weeks after surgery. Bladder function was determined vivo awake cystometry, micturition pattern analysis, 24‐h urine collection. Bladders harvested vitro pharmacological investigation isometric tension recording. major...
This feasibility study established an experimental protocol to evaluate brain activation patterns using fluorodeoxyglucose positron emission tomography ((18F)FDG-PET) during volume-induced voiding and isovolumetric bladder contractions in rats. Female Sprague-Dawley rats were anaesthetized with urethane underwent either cystometry or simultaneous functional PET imaging after injection of (18F)FDG the tail vein. Brain glucose metabolism both groups was compared their respective control...
You have accessJournal of UrologyBladder and Urethra: Anatomy, Physiology Pharmacology I1 Apr 2015PD7-07 A NOVEL TARGET FOR UNDERACTIVE BLADDER DISEASE: TRPV4 CATION CHANNEL ACTIVATION IMPROVES FUNCTION IN RAT MODEL DETRUSOR UNDERACTIVITY Yves Deruyver, Emmanuel Weyne, Karel Dewulf, Wouter Everaerts, Thomas Voets, Dirk De Ridder DeruyverYves Deruyver More articles by this author , WeyneEmmanuel Weyne DewulfKarel Dewulf EveraertsWouter Everaerts VoetsThomas Voets RidderDirk View All Author...
You have accessJournal of UrologyBladder and Urethra: Anatomy, Physiology Pharmacology II1 Apr 2015MP21-06 BLADDER SMOOTH MUSCLE CELLS UNDERGO A SYNTHETIC PHENOTYPE SWITCH IN RAT MODEL OF NEUROGENIC UNDERACTIVE DISEASE Emmanuel Weyne, Yves Deruyver, Karel Dewulf, Roma Rietjens, Trinity J Bivalacqua, Dirk De Ridder, Frank Van der Aa, Maarten Albersen WeyneEmmanuel Weyne More articles by this author , DeruyverYves Deruyver DewulfKarel Dewulf RietjensRoma Rietjens BivalacquaTrinity Bivalacqua...
You have accessJournal of UrologyBladder and Urethra: Anatomy, Physiology Pharmacology I1 Apr 2015PD7-02 DELETION OF THE TRPV4 CATION CHANNEL LEADS TO DECREASED SENSORY INPUT INTO CENTRAL NERVOUS SYSTEM DURING MICTURITION CYCLE: A PET IMAGING STUDY IN RATS Yves Deruyver, Roma Rietjens, Jan Franken, Ann Van Santvoort, Cindy Casteels, Thomas Voets, Dirk De Ridder DeruyverYves Deruyver More articles by this author , RietjensRoma Rietjens FrankenJan Franken SantvoortAnn Santvoort CasteelsCindy...
You have accessJournal of UrologyUrodynamics/Lower Urinary Tract Dysfunction/Female Pelvic Medicine: Basic Research & Pathophysiology I1 Apr 2016MP60-19 MUSCARINIC INDUCED BLADDER CONTRACTILITY IS ALTERED IN AN ANIMAL MODEL FOR NEUROGENIC DETRUSOR UNDERACTIVITY Karel Dewulf, Emmanuel Weyne, Yves Deruyver, Rieta Van Bree, Dirk De Ridder, Maarten Albersen, and Wouter Everaerts DewulfKarel Dewulf More articles by this author , WeyneEmmanuel Weyne DeruyverYves Deruyver BreeRieta Bree RidderDirk...