A5022453588- Lipid metabolism and biosynthesis
- Congenital heart defects research
- Adipose Tissue and Metabolism
- Genetics and Neurodevelopmental Disorders
- Corneal Surgery and Treatments
- Circadian rhythm and melatonin
- Connexins and lens biology
- Redox biology and oxidative stress
- Pancreatic function and diabetes
- Genetics, Aging, and Longevity in Model Organisms
- RNA Research and Splicing
- Glutathione Transferases and Polymorphisms
National Yang Ming Chiao Tung University
2022-2024
Abstract Background CDGSH iron-sulfur domain-containing protein 2 (CISD2), a pro-longevity gene, mediates healthspan in mammals. CISD2 is down-regulated during aging. Furthermore, persistently high level of promotes longevity and ameliorates an age-related skin phenotype transgenic mice. Here we translate the genetic evidence into pharmaceutical application using potent activator, hesperetin, which enhances expression HEK001 human keratinocytes from older person. We also treated naturally...
Abstract Regulation of fatty acid uptake, lipid production and storage, metabolism droplets (LDs), is closely related to homeostasis, adipocyte hypertrophy obesity. We report here that stomatin, a major constituent raft, participates in adipogenesis maturation by modulating signaling pathways. In adipocyte-like cells, increased stomatin promotes LD growth or enlargements facilitating LD-LD fusion. It also uptake from extracellular environment recruiting effector molecules, such as FAT/CD36...
Lissencephaly is a neurodevelopmental disorder characterized by loss of brain surface convolutions caused genetic variants that disrupt neuronal migration. However, the origins remain unidentified in nearly one-fifth people with lissencephaly. Using whole-exome sequencing, we identified de novo BAIAP2 variant, p.Arg29Trp, an individual lissencephaly posterior more severe than anterior (P>A) gradient, implicating as potential gene. Spatial transcriptome analysis developing mouse cortex...