A5060305546- Medical Imaging and Pathology Studies
- Atomic and Subatomic Physics Research
- Case Reports on Hematomas
- Advanced NMR Techniques and Applications
- Advanced MRI Techniques and Applications
- Diagnosis and treatment of tuberculosis
- Soft tissue tumor case studies
- Quantum, superfluid, helium dynamics
- MRI in cancer diagnosis
- Renal and Vascular Pathologies
- Gastrointestinal disorders and treatments
- Esophageal and GI Pathology
- Appendicitis Diagnosis and Management
- Liver Disease Diagnosis and Treatment
- Gallbladder and Bile Duct Disorders
- Nuclear Physics and Applications
- Hepatocellular Carcinoma Treatment and Prognosis
- Diverticular Disease and Complications
- Liver Disease and Transplantation
- Sarcoma Diagnosis and Treatment
- Colorectal Cancer Surgical Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Radiomics and Machine Learning in Medical Imaging
- Pediatric Hepatobiliary Diseases and Treatments
- Ovarian cancer diagnosis and treatment
University of Virginia
2013-2025
University of Virginia Health System
2001-2021
Atrium Health Wake Forest Baptist
2018
University of Virginia Hospital
2017
University of California, San Francisco
2015
United States University
2012-2013
Charlottesville Medical Research
2001
University Medical Center Utrecht
1998
Philips (Netherlands)
1998
University of Virginia Medical Center
1985-1990
Using a new method of xenon laser-polarization that permits the generation liter quantities hyperpolarized 129Xe gas, first imaging results from human chest and spectroscopy head have been obtained. With polarization levels approximately 2%, cross-sectional images lung gas-spaces with voxel volume 0.9 cm3 (signal-to-noise ratio (SNR), 28) were acquired three dissolved-phase resonances in spectra detected. In head, one prominent resonance, presumably brain parenchyma, was anticipated...
Asthma is a disease characterized by chronic inflammation and reversible obstruction of the small airways resulting in impaired pulmonary ventilation. Hyperpolarized 3He magnetic resonance (MR) lung imaging new technology that provides detailed image was performed 10 asthmatics healthy subjects. Seven had ventilation defects distributed throughout lungs compared with none normal These were more numerous larger two symptomatic who abnormal spirometry. Ventilation studied over time...
PURPOSE: To quantitatively evaluate hyperpolarized helium 3 (3He) diffusion magnetic resonance (MR) images of the lung in patients with emphysema and to determine whether apparent coefficients (ADCs) measured MR imaging correlate spirometric indexes. MATERIALS AND METHODS: Hyperpolarized 3He was performed 16 healthy volunteers 11 patients. Coronal diffusion-sensitized were obtained during suspended respiration after inhalation laser-polarized gas, ADC calculated. Spirometry immediately...
Thirty-two magnetic resonance imaging examinations of the lungs were performed in 16 subjects after inhalation 1–2 L helium 3 gas that was laser polarized to 10%–25%. The distribution generally uniform, with visualization fissures most cases. Ventilation defects demonstrated smokers and a subject allergies. technique has potential for evaluating small airways disease.
PURPOSE: To determine the accuracy and repeatability of ultrasonography (US) with ellipsoid formula in calculating renal volume. MATERIALS AND METHODS: The volumes 20 volunteers aged 19–51 years were determined by using US magnetic resonance (MR) imaging voxel-count method two independent observers for each modality. performed all measurements twice, an interval between first second examinations. was reference standard. Repeatability evaluated SD difference (method Bland Altman). RESULTS:...
Purpose: To determine changes in regional airflow obstruction over time the lungs of patients with asthma, as demonstrated hyperpolarized helium 3 (3He) magnetic resonance (MR) imaging, and to assess correlations disease severity use asthma medications. Materials Methods: Institutional review board approval written informed consent were obtained for this HIPAA-compliant study. Use 3He was approved by U.S. Food Drug Administration. Forty-three underwent 103 MR imaging studies total; 26 imaged...
Abstract An optimized interleaved‐spiral pulse sequence, providing high spatial and temporal resolution, was developed for dynamic imaging of pulmonary ventilation with hyperpolarized 3 He, tested in healthy volunteers patients lung disease. Off‐resonance artifacts were minimized by using a short data‐sampling period per interleaf, gradient‐fidelity errors compensated measured k ‐space trajectories image reconstruction. A nonsequential acquisition order implemented to improve quality during...
To determine the accuracy of gadolinium-enhanced breath-hold magnetic resonance (MR) angiography in diagnosis renal artery stenosis and visualization accessory arteries.Forty-four patients suspected having 10 potential kidney donors, all whom were scheduled to undergo elective intraarterial digital subtraction (DSA), studied. Three-dimensional gradient-echo MR was performed at 1.5 T with following parameters: repetition time, 13.5 msec; echo 3.5 flip angle, 60 degrees; 195 x 512 matrix;...
The purpose of this study was to define the common appearances hepatocellular carcinoma (HCC) in patients North America by analyzing T1-weighted, T2-weighted, and serial gadolinium-enhanced gradient-echo images interpreted radiologists at multiple institutions America. One hundred thirteen consecutive with HCC from eight were included retrospective case series. Inclusion criteria MR imaging examinations performed on 1.5-T imagers using T1-weighted breath-hold spoiled images, T2-weighted...
PURPOSE: To compare spiral computed tomographic (CT) angiography with optimized digital subtraction (DSA) for accurate detection and quantification of renal artery stenosis. MATERIALS AND METHODS: In 71 consecutive patients possible renovascular hypertension, CT was performed the arteries before DSA. Optimized DSA (performed projection angles calculated from axial source images) used as standard. Two independent observers evaluated spinal angiograms presence grade Sensitivity, specificity,...
PURPOSE: To determine if hepatic metastases can be distinguished from cavernous hemangiomas by pattern analysis of magnetic resonance (MR) images obtained prior to and following administration gadoteridol at standard (0.1 mmol/kg) triple (0.3 doses. MATERIALS AND METHODS: Ninety-five patients with proved (n = 71) or 24) underwent MR imaging 16 different institutions. T2-weighted spin-echo T1-weighted were before after administration. Two independent blinded reviewers rated individual...
Eleven patients who underwent abdominoperineal resection for rectosigmoid carcinoma were examined with magnetic resonance (MR) imaging suspected recurrent tumor in the presacral space. There 12 masses 11 patients. Ten lesions malignant, and two only nonneoplastic inflammatory tissue was found. The signal intensity (SI) of each lesion relative to that muscle determined visually correlated histologic findings at surgery or biopsy. SIs malignant benign indistinguishable. All showed areas high...
Twenty-nine patients with rectal carcinoma were examined magnetic resonance (MR) imaging at 1.0 T. In most a Helmholtz coil was used and bowel distention obtained barium enema balloon tip. The MR findings graded according to the modified Astler-Coller staging classification correlated surgical or histopathologic results. Correct diagnosis made in nine of 12 stage A B1 tumors. Overestimation occurred other three patients, who had previously undergone radiation therapy surgery. Local correctly...
This pilot study evaluated the effect of short- and long-term ivacaftor treatment on hyperpolarized 3He-magnetic resonance imaging (MRI)-defined ventilation defects in patients with cystic fibrosis aged ≥12years a G551D-CFTR mutation.Part A (single-blind) comprised 4weeks treatment; Part B (open-label) 48weeks treatment. The primary outcome was change from baseline total defect (TVD; volume:total lung volume ratio).Mean TVD ranged -8.2% (p=0.0547) to -12.8% (p=0.0078) (n=8) -6.3% (p=0.1953)...
Inhaled hyperpolarized helium-3 (/sup 3/He) gas is a new magnetic resonance (MR) contrast agent that being used to study lung functionality. To evaluate the total ventilation from /sup 3/He MR images, it necessary segment cavities. This difficult accomplish using only so traditional proton 1/H) images are frequently obtained concurrent with examination. Segmentation of cavities MRI first step in analysis images. In this paper, we develop an active contour model provides smooth boundary and...