A5031413284- Bacterial Infections and Vaccines
- Pneumonia and Respiratory Infections
- Streptococcal Infections and Treatments
- Antibiotic Use and Resistance
- Influenza Virus Research Studies
- Pneumocystis jirovecii pneumonia detection and treatment
Children's Hospital
2020-2025
Tunis El Manar University
2020-2024
Faculté de médecine de Tunis
2024
Background/Objectives: Streptococcus pneumoniae is a leading respiratory pathogen responsible for significant morbidity and mortality, particularly among vulnerable populations. Understanding its antimicrobial resistance patterns serotype distribution crucial guiding treatment prevention strategies. This study aims to examine these trends in S. isolates from Tunisia over two-decade period (2000–2019). Methods: A retrospective time series analysis was conducted on data (n = 4284) gathered...
Since the 1990s, epidemiology of bacterial meningitis worldwide has changed thanks to vaccination. In Tunisia, main causative pathogens were Streptococcus pneumoniae, Neisseria meningitidis and Haemophilus influenzae serotype b (Hib). Only Hib vaccination was available during our study period.We performed a laboratory case report based-study suspected in Northern Tunisia from January 2014 June 2017.CSF samples obtained children beyond neonatal age with suspicion tested by two real time PCRs,...
The worldwide burden of disease bacterial meningitis remains high, despite the decreasing incidence following introduction routine vaccination campaigns.The aim our study was to evaluate epidemiological and bacteriological profile paediatric (BM) in Tunisian children, during period 2003-2019, implementation Haemophilus influenzae type b (Hib) vaccine (April 2011) before 10-valent pneumoccocal conjugate (PCV10) childhood immunization program.All bacteriologically confirmed cases BM admitted...
The changing epidemiological profile of invasive Haemophilus influenzae infections (IIHi) is noted in the post-vaccination era. aim this study was to characterize phenotypically and genotypically (Hi) isolates detected Tunisian pediatric patients. A retrospective conducted microbiology laboratory Children's Hospital Tunis over ten years (2013-2023). All IIHi cases were included. Molecular identification serotyping through qPCR. typing analysis resistance genes extracted from whole genome...
Accurate identification of Mitis group streptococci especially Streptococcus pneumoniae and pseudopneumoniae seems difficult due to the lack specific sensitive tests. We performed an approach for atypical pneumococci in pediatric Tunisian population. In this study, 49 streptococcal isolates that were considered as S. analyzed by: optochin susceptibility ambient 5% CO2 atmosphere, oxgall disk sensitivity, PCR targeting several genes antimicrobial susceptibility.The combined results...