A5076525815- Bacterial Infections and Vaccines
- Pneumonia and Respiratory Infections
- SARS-CoV-2 and COVID-19 Research
- Streptococcal Infections and Treatments
- Antibiotic Use and Resistance
- Infectious Aortic and Vascular Conditions
- Escherichia coli research studies
- COVID-19 Impact on Reproduction
- Antifungal resistance and susceptibility
- Infective Endocarditis Diagnosis and Management
- COVID-19 Clinical Research Studies
- Pharmaceutical and Antibiotic Environmental Impacts
- Immunodeficiency and Autoimmune Disorders
- Pneumocystis jirovecii pneumonia detection and treatment
- Cystic Fibrosis Research Advances
- Viral Infections and Outbreaks Research
- Viral gastroenteritis research and epidemiology
- Salmonella and Campylobacter epidemiology
- Antibiotic Resistance in Bacteria
- Influenza Virus Research Studies
Children's Hospital
2022-2025
Tunis El Manar University
2023-2024
Faculté de médecine de Tunis
2023-2024
Tunis University
2023
Introduction The Delta variant posed an increased risk to global public health and rapidly replaced the pre-existent variants worldwide. In this study, genetic diversity spatio-temporal dynamics of 662 SARS-CoV2 genomes obtained during wave across Tunisia were investigated. Methods Viral whole genome partial S-segment sequencing was performed using Illumina Sanger platforms, respectively lineage assignemnt assessed Pangolin version 1.2.4 scorpio 3.4.X. Phylogenetic phylogeographic analyses...
Candida albicans chronically colonizes the respiratory tract of patients with Cystic Fibrosis (CF). It competes CF-associated pathogens (e.g. Pseudomonas aeruginosa) and contributes to disease severity. We hypothesize that C. undergoes specific adaptation mechanisms explain its persistence in CF lung environment. To identify underlying genetic phenotypic determinants, we serially recovered 146 clinical isolates over a period 30 months from sputum 25 antifungal-naive patients. Multilocus...
Background/Objectives: Streptococcus pneumoniae is a leading respiratory pathogen responsible for significant morbidity and mortality, particularly among vulnerable populations. Understanding its antimicrobial resistance patterns serotype distribution crucial guiding treatment prevention strategies. This study aims to examine these trends in S. isolates from Tunisia over two-decade period (2000–2019). Methods: A retrospective time series analysis was conducted on data (n = 4284) gathered...
Due to low susceptibility of coronavirus disease 2019 (COVID-19) in children, limited studies are available regarding COVID-19 the pediatric population Tunisia. The current study evaluated incidence, clinical characteristics, and outcomes severe acute respiratory syndrome type 2 (SARS-CoV-2) infection among children hospitalized at Béchir Hamza Children's Hospital. A retrospective cohort analysis was conducted using hospital database between March 2020 February 2022 with aged ≤15 years...
The worldwide burden of disease bacterial meningitis remains high, despite the decreasing incidence following introduction routine vaccination campaigns.The aim our study was to evaluate epidemiological and bacteriological profile paediatric (BM) in Tunisian children, during period 2003-2019, implementation Haemophilus influenzae type b (Hib) vaccine (April 2011) before 10-valent pneumoccocal conjugate (PCV10) childhood immunization program.All bacteriologically confirmed cases BM admitted...
Actually, no data on the prevalence of plasmid colistin resistance in Tunisia are available among clinical bacteria.This study aimed to investigate current epidemiology and spread mcr gene Gram-negative bacteria (GNB) isolated from six Tunisian university hospitals.A total 836 GNB strains were inoculated COL-R agar plates with selective screening for isolation resistant colistin. For selected isolates, genes, beta-lactamases associated-resistance genes molecular characterisation screened by...
The changing epidemiological profile of invasive Haemophilus influenzae infections (IIHi) is noted in the post-vaccination era. aim this study was to characterize phenotypically and genotypically (Hi) isolates detected Tunisian pediatric patients. A retrospective conducted microbiology laboratory Children's Hospital Tunis over ten years (2013-2023). All IIHi cases were included. Molecular identification serotyping through qPCR. typing analysis resistance genes extracted from whole genome...
Accurate identification of Mitis group streptococci especially Streptococcus pneumoniae and pseudopneumoniae seems difficult due to the lack specific sensitive tests. We performed an approach for atypical pneumococci in pediatric Tunisian population. In this study, 49 streptococcal isolates that were considered as S. analyzed by: optochin susceptibility ambient 5% CO2 atmosphere, oxgall disk sensitivity, PCR targeting several genes antimicrobial susceptibility.The combined results...