A5048082436- Skin Protection and Aging
- melanin and skin pigmentation
- Phytochemicals and Antioxidant Activities
- Bee Products Chemical Analysis
- Antioxidant Activity and Oxidative Stress
- Genomics, phytochemicals, and oxidative stress
- Photodynamic Therapy Research Studies
- Essential Oils and Antimicrobial Activity
- Nanoparticles: synthesis and applications
- Cell death mechanisms and regulation
- Tannin, Tannase and Anticancer Activities
- Medicinal Plants and Neuroprotection
- Cancer therapeutics and mechanisms
- Curcumin's Biomedical Applications
- Drug Transport and Resistance Mechanisms
- DNA Repair Mechanisms
- MicroRNA in disease regulation
- Diverse Scientific Research Studies
- Botanical Research and Applications
- Vitamin C and Antioxidants Research
- Alcohol Consumption and Health Effects
- Nuts composition and effects
- Flavonoids in Medical Research
- Advanced Nanomaterials in Catalysis
- Effects and risks of endocrine disrupting chemicals
Pondicherry University
2022-2024
Thiruvalluvar University
2019-2022
Annamalai University
2015-2020
Ultraviolet-B radiation (285–320 nm) elicits a number of cellular signaling elements. We investigated the preventive effect linalool, natural monoterpene, against UVB-induced oxidative imbalance, activation mitogen-activated protein kinase (MAPK) and nuclear factor kappa-B (NF-κB) in HDFa cells. observed that linalool treatment (30 μM) prevented acute UVB-irradiation (20 mJ/cm2) mediated loss activities antioxidant enzymes The comet assay results illustrate significantly prevents...
P-Glycoprotein (P-gp) serves as a therapeutic target for the development of inhibitors to overcome multidrug resistance in cancer cells.
Abstract In this study, the effect of caffeic acid ( CA ) on both acute and chronic UVB ‐irradiation–induced inflammation photocarcinogenesis was investigated in S wiss albino mice. Animals were exposed to 180 mJ cm −2 once daily for 10 consecutive days thrice weekly 30 weeks study respectively. exposure showed edema formation, increased lipid peroxidation decreased antioxidant status with activation inflammatory molecules such as TNF ‐ α , IL ‐6, COX ‐2 NF κ B . However, (15 mg per...
In the present study, we investigated potential of opuntiol, isolated from Opuntia ficus-indica, against UVA radiation-mediated inflammation and skin photoaging in experimental animals. The skin-shaved mouse was subjected to exposure at dosage 10 J/cm2 per day for ten consecutive days (cumulative dose: 100 J/cm2). Opuntiol (50 mg/kg b.wt.) topically applied one hour before each exposure. (100 J/cm2) induces epidermal hyperplasia collagen disarrangement which leads photoaging-associated...
Signal transducers and activators of transcription 3 (STAT3) play a critical role in inflammation, proliferation carcinogenesis. Inhibition JAK-STAT3 signaling is proved to be novel target for prevention UVB-induced skin In this study, chronic UVB irradiation (180 mJ cm(-2) ; weekly thrice 30 weeks) induces the expression IL-10 JAK1 that eventually activates STAT3 which leads proliferative antiapoptotic markers such as PCNA, Cyclin-D1, Bcl2 Bcl-xl, respectively. Caffeic acid (CA) inhibits...
We synthesized the gold nanoparticles (AuNPs) using wedelolactone (WDL) and characterized them UV-visible spectroscopy, fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopic (SEM), transmission (TEM), energy dispersive diffraction, atomic force (AFM) studies. The electronic spectrum exhibited an absorption peak at 535 nm. FT-IR results proved that WDL was stabilized on surface of AuNPs by acting as a capping or reducing agent. crystalline...
In the present study, authors have attempted to fabricate Polydatin encapsulated Poly [lactic-co-glycolic acid] (POL-PLGA-NPs) counteract 7,12-dimethyl benzyl anthracene (DMBA) promoted buccal pouch carcinogenesis in experimental animals. The bio-formulated POL-PLGA-NPs were characterized by dynamic light scattering (DLS), Fourier transform infrared (FTIR) spectroscopy, X-ray powder diffraction (XRD) pattern analysis, and transmission electron microscope (TEM). addition, nano-chemopreventive...
This study aimed to assess the apoptosis-inducing mechanism of zinc oxide nanoparticles (ZnO NPs) stabilized by Solanum xanthocarpum plant extract in human osteosarcoma MG63 cells. In present study, we synthesized ZnO NPs from S. and evaluated its anticancer on MG 63 The were characterized ultraviolet spectroscopy, X-ray crystallography, transmission electron microscopy, energy dispersive X-ray, Fourier-transform infrared spectroscopy analysis. mean size was 21.62 ± 7.45 nm spherical shape....
Objective: To examine the effects of p-coumaric acid on ethanol-induced kidney injury in Swiss Wistar rats.Methods: Ethanol (25% v/v) was used to induce nephrotoxicity rats. p-Coumaric orally administered at 50, 100, or 200 mg/kg body weight. The levels oxidative parameters were determined; pro-inflammatory biomarkers analyzed by Western blotting and apoptotic protein immunohistochemistry.Results: treated rats showed decreased antioxidants aberrant production cytokines (IL-6, IL1P, TNF-α),...
Solar ultraviolet-B radiation (UVB) has severe adverse effects on the structure and functions of skin. Although, UVB (290–320 nm) represents only 5–10% UV light reaching earth’s surface, its contribution towards photoaging is tremendous. In this present study was investigate photoprotective effect methanolic extract male flower J. regia L. (MEJR) against induced in human epidermal keratinocytes (HaCaT). Cells were exposed to UVB-irradiation at a dose 20 mJ/cm2, induces activation several...
The objective of this study was to evaluate the protective effect apigenin against radiation-induced gastrointestinal (GI) damages in whole-body irradiated (WBI) Swiss albino mice. mice were pre-treated with (15 mg/kg body wt.) intraperitoneally for six consecutive days, and on seventh day, exposed 7 Gy WBI. Histological findings revealed a deterioration crypt-villus architecture intestine. Conversely, pre-treatment ameliorated intestinal restored architecture. Besides, modulates apoptotic...
Abstract This study has explored the fact that geraniol prevents isoproterenol (ISO)‐induced oxidative stress and inflammation‐mediated myocardial infarction (MI) through enhanced expression of peroxiredoxin‐1 (Prdx‐1) in experimental animal models. The strategies MI were stimulated subcutaneous direction ISO (85 mg/kg body weight) for 14 days. ISO‐directed models showed elevated heart rate levels cardiac markers (serum creatine kinase [CK], serum CK‐myocardial band, C‐reactive proteins,...