A5041063089- Iron Metabolism and Disorders
- Hemoglobinopathies and Related Disorders
- Blood groups and transfusion
- Advanced Glycation End Products research
- Oral microbiology and periodontitis research
- Diabetes and associated disorders
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Pancreatic function and diabetes
- Oral and gingival health research
- Salivary Gland Disorders and Functions
- Prenatal Screening and Diagnostics
University of Illinois Chicago
2018-2020
University of Illinois Urbana-Champaign
2018
Background The results from cross sectional and longitudinal studies show that periodontitis is closely associated with cognitive impairment (CI) Alzhemer's Disease (AD). Further, using animal model of human post-mortem brain tissues subjects AD strongly suggest a gram-negative periodontal pathogen, Porphyromonas gingivalis (Pg) and/or its product gingipain is/are translocated to the brain. However, neuropathology resulting Pg oral application not known. In this work, we tested hypothesis...
Results from epidemiological and prospective studies indicate a close association between periodontitis diabetes. However the mechanisms by which periodontal pathogens influence development of prediabetes/diabetes are not clear. We previously reported that oral administration pathogen, Porphyromonas gingivalis (Pg) to WT mice results in insulin resistance, hyperinsulinemia, glucose intolerance Pg translocates pancreas. In current study, we determined specific localization relation mouse...