The purpose of this manuscript is to revise and update the previous consensus statement on inflammatory airway disease (IAD) in horses. Since 2007, a large number scientific articles have been published topic these new findings led significant evolution our understanding IAD.

The purpose of this consensus statement is to provide a review current knowledge and opinions concerning inflammatory airway disease (IAD) help practitioners differentiate IAD from heaves (or recurrent obstruction; RAO) other respiratory diseases horses.

The purpose of this consensus statement is to provide a review current knowledge and opinions concerning inflammatory airway disease (IAD) help practitioners differentiate IAD from heaves (or recurrent obstruction; RAO) other respiratory diseases horses.

Published studies of exercise-induced pulmonary hemorrhage (EIPH), when assessed individually, often provide equivocal or conflicting results. Systematic reviews aggregate evidence from individual to a global assessment the quality and inform recommendations.Evaluate determine: if EIPH adversely affects health, welfare both horses; athletic capacity efficacy prophylactic interventions for EIPH; furosemide horses.None.Systematic review. A panel 7 experts was formed assess in peer reviewed...

Pituitary adenomas are commonly reported in older horses. The typical clinical signs associated with this condition, also known as equine Cushing's disease (ECD), related to increased adrenocorticotropin (ACTH) production resulting hyperadrenocorticism. primary purpose of study was determine whether plasma ACTH concentrations differed between cushingoid and healthy second objective the effects blood sample handling techniques on concentrations. A commercial human radioimmunoassay (RIA) used...

Background Mild equine asthma is presumed to arise in response environmental exposures but the relative impact of differing inflammatory phenotypes upon performance are largely unexplored. Hypotheses : Airway inflammation negatively affects and cytological phenotype varies with exposure. Animals Thoroughbred racehorses active training racing. Methods Thoroughbreds were recruited 24‐48 hours before Each horse was eligible for re‐enrollment each race entry. Within one hour completion, physical...

The prevalence of preexisting immunity to adenoviruses in the majority human population might adversely impact development adaptive immune responses against adenovirus vector-based vaccines. To address this issue, we primed BALB/c mice either intranasally (i.n.) or intramuscularly (i.m.) with varying doses wild type (WT) subtype 5 (HAd5). Following HAd5, immunized animals via i.n. i.m. route inoculation a HAd vector (HAd-HA-NP) expressing hemagglutinin (HA) and nucleoprotein (NP)...

Abstract Objective —To evaluate the association among clinical signs, results of cytologic evaluation bronchoalveolar lavage (BAL) fluid, and measures pulmonary function in horses with inflammatory respiratory disease. Animals —9 healthy horses, 5 airway disease (IAD), 9 chronic obstructive (COPD). Procedure —Clinical examination, lung tests, BAL were performed on each horse. Results —Standard mechanics exacerbated COPD differed significantly from those horses; however, there few differences...

Summary The purpose of this study was to evaluate the relationship between bronchoalveolar lavage (BAL) cytology, arterial blood gases and plasma lactate concentration during a standardised treadmill test (STT) in racehorses with small‐airway inflammation (SAI), or exercise‐induced pulmonary haemorrhage (EIPH). Sixteen Thoroughbred 20 Standardbred actively racing racehorses, were divided into control group (n=10), EIPH (n=13) SAI (n = 13). Each STT consisted 2 min trot at 4 m/s followed by 5...

Inflammatory Airway Disease (IAD), exercise-induced pulmonary hemorrhage (EIPH), and upper airway obstruction (UAO) are common respiratory tract diseases that can decrease performance. The purpose of this retrospective study was to compare bronchoalveolar lavage fluid cytology arterial blood gas analysis during a treadmill test by poorly performing racehorses presented Purdue University. One hundred thirty-two horses with history poor performance were included in study. Ten no or diagnosis...

Background Inflammatory airway disease ( IAD ) in horses is a widespread, performance‐limiting syndrome believed to develop response inhaled irritants the barn environment. Objectives To evaluate changes bronchoalveolar lavage fluid BALF cytology and exposure particulates, endotoxin, ammonia during horses' first month training. Animals Forty‐nine client‐owned 12‐ 36‐month‐old Thoroughbred entering race Methods In this prospective cohort study, convenience sample of was assigned be fed hay...

Background Omega‐3 polyunsaturated fatty acid ( PUFA ) may benefit humans and animals with chronic inflammatory diseases. Hypothesis supplementation improves clinical signs, lung function, airway inflammation in horses recurrent obstruction RAO disease IAD ). Animals Eight research 35 client‐owned horses. Methods A pilot study examined the dose of that can alter plasma composition. Then, a randomized, controlled trial was performed . Horses were fed complete pelleted diet no hay randomly...

Inflammatory Airway Disease (IAD), exercise‐induced pulmonary hemorrhage (EIPH), and upper airway obstruction (UAO) are common respiratory tract diseases that can decrease performance. The purpose of this retrospective study was to compare bronchoalveolar lavage fluid cytology arterial blood gas analysis during a treadmill test by poorly performing racehorses presented Purdue University. One hundred thirty‐two horses with history poor performance were included in study. Ten no or diagnosis...

Abstract Objective —To determine whether administration of glucocorticoids provides additional benefits to environmental management horses with recurrent airway obstruction (RAO). Animals —28 RAO. Procedure —Horses were classified as having mild, moderate, or severe Within each category, randomly assigned receive inhaled fluticasone propionate, control substance, oral prednisone. During the 4- week study, maintained outdoors and fed a pelleted feed. Clinical scores, pulmonary function,...

To identify risk factors for recurrent airway obstruction (RAO) among horses examined at veterinary teaching hospitals in North America.Retrospective case-control study.1,444 with RAO and 1,444 control other reasons.The Veterinary Medical Database was searched records of which diagnosed. A group identified by randomly selecting a horse diagnosis than that matched the institution year admission each RAO. Information obtained included hospital, month, age, sex, breed, discharge status. The...

The diagnostic accuracy of a PCR used to identify horses shedding Salmonella spp. in their feces during hospitalization was estimated, relative bacterial culture serially collected fecal samples, using longitudinal data. Five or more samples were from each 116 admitted as inpatients, for reasons other than gastrointestinal disease, between July 26, 2001 and October 25, 2002. All 873 tested with based on oligonucleotide primers defining highly conserved segment the histidine transport operon...

Glucocorticoid (GC) therapy is recognized to be effective for the treatment of recurrent airway obstruction (RAO) in horses. Anti-inflammatory properties GC are thought mediated by suppression inflammatory gene expression via inhibition transcription factors such as nuclear factor-kappaB (NF-kappaB) and activator protein-1 (AP-1). The purpose this study was evaluate effect low-dose inhaled beclomethasone dipropionate injectable dexamethasone 21-isonicotinate on clinical signs, pulmonary...

Reasons for performing study: Studies investigating the clinical efficacy of albuterol administered with same propellant and commercially available delivery devices in horses recurrent airway obstruction (RAO) are not currently available. Objectives: To determine aerosolised to RAO by means 2 available, hand-held devices. Methods: Ten were kept a dusty environment fed mouldy hay induce obstruction. Lung mechanics measured before after procedure. ΔPmax was 5 min administration 180 µg from...