Thirty-eight endurance horses underwent clinical and ancillary examinations, including haematological biochemical evaluation, standardised exercise tests both on a treadmill in the field, Doppler echocardiography, impulse oscillometry, video endoscopy collection of respiratory fluids. All examined poorly performing were affected by subclinical diseases, most them had multiple concomitant disorders. On contrary, well-performing free any disease. The frequently diagnosed diseases disorders,...

To test the hypothesis that reactive oxygen species could be associated to lower airway disorders occurring in horses suffering from recurrent obstruction (RAO), indices of oxidative stress were studied blood and pulmonary epithelium lining fluid 5 RAO either clinical remission or 24 h after onset a crisis bronchospasm healthy horses. Venous bronchoalveolar lavage (BALF) samples collected analysed for reduced glutathione (GSH), oxidised (GSSG), total (TGSH), redox ratio (GRR) haemolysate...

Summary Pleural, tracheal, pharyngeal and mask pressures as well airflow tidal volume of five ponies on a treadmill (incline 8.3°) were recorded simultaneously while resting, walking, trotting slowly, fast, after standing for 30 secs 5 mins the end exercise. The curves obtained used to calculate total pulmonary resistance (RL), lower airway (RLA) upper (RUA). latter was also divided into nasal (Rnas) laryngeal plus extrathoracic tracheal (Retr+lar). Furthermore, inspiratory expiratory...

Summary This study investigated some physiological responses to exercise performed by a horse during show jumping. The effects of jumping on heart rate (HR), blood lactate (LA) and other values were studied in nine normal horses participating at the Belgian Junior Championship. Venous was sampled before immediately after analysed for packed cell volume, LA, glucose (GLU), total plasma protein, bicarbonate, sodium, potassium (K + ), chloride, calcium activities dehydrogenase, creatine...

The effects of training and detraining on ventilation during a standardised exercise test were investigated. Ten healthy Thoroughbred horses underwent 5 treadmill tests (SET): SET1, at the start experimental period; SET2, after 3 weeks acclimatisation; SET3, week aerobic training; SET4 anaerobic (i.e. interval) SET5, detraining. SETs carried out in an air-conditioned laboratory inclined 6 degrees. Respiratory airflow, tidal volume (VT), respiratory frequency (RF) expired minute (VE) obtained...

Inflammatory airway disease (IAD) is a nonseptic condition of the lower respiratory tract. Its negative impact on function has previously been described using either forced expiration or oscillations techniques. However, sedation drug-induced bronchoconstriction were usually required. The impulse oscillometry system (IOS) noninvasive and sensitive test validated in horses, which could be useful to evaluate IAD-affected horses without further procedures.To determine sensitivity IOS detecting...

Background Risk factors for cardiac diseases in horses have not been explored a large population of animals. Objectives To describe risk various hospital‐based horses. Animals Files 3,434 admitted at the Internal Medicine Department Liege Equine Teaching Hospital between 1994 and 2011 were reviewed those, 284 categorized as having moderate‐to‐severe disease. Methods Observational study. After calculating prevalence each disease, we tested whether breed (chi‐square test) or sex, age, body...

Summary An oxidant/antioxidant imbalance in favour of oxidants has been identified as playing a decisive role the pathogenesis chronic inflammatory airway diseases. Nutritional antioxidant supplementation might reduce oxidative damage by enhancement defence, thereby modulating processes. In placebo‐controlled, blind study, it was tested whether dietary supplement administered for 4 weeks would improve lung function and inflammation heaves‐affected horses. Eight horses clinical remission...

Summary In heaves‐affected horses the relation between oxidant status, airway inflammation (AI) and pulmonary function (PF) is unknown. The status of blood epithelial lining fluid (PELF) healthy (H, n = 6) in clinical remission (REM, crisis (CR, 7) was assessed at rest, during afterstandardised exercise test by measurement reduced oxidised glutathione, glutathione redox ratio [GRR%]; uric acid 8‐epi‐PGF 2α . Oxidant related to PF parameters (mechanics breathing arterial gas tension) AI...

Glucocorticoid (GC) therapy is recognized to be effective for the treatment of recurrent airway obstruction (RAO) in horses. Anti-inflammatory properties GC are thought mediated by suppression inflammatory gene expression via inhibition transcription factors such as nuclear factor-kappaB (NF-kappaB) and activator protein-1 (AP-1). The purpose this study was evaluate effect low-dose inhaled beclomethasone dipropionate injectable dexamethasone 21-isonicotinate on clinical signs, pulmonary...

The objective of this study was to test the hypothesis that stabled COPD horses can be maintained in clinical remission by replacing hay grass silage and bedding made wood shavings (Period B) wheat straw C) during 6 weeks, respectively. At end these different periods, pulmonary function assessed mechanics breathing arterial blood analyses. These results were compared those measured obtained after 2 months pasture A). No significant difference observed between 3 periods neither values for...

Due to technical implementations and lack of sensitivity, pulmonary function tests are seldom used in clinical practice. Impulse oscillometry (IOS) could represent an alternative method.To define feasibility, methodology repeatability IOS, a forced oscillation technique that measures respiratory resistance (Rrs) reactance (Xrs) from 5 35 Hz during spontaneous breathing, horses.Using 38 healthy horses, Rrs Xrs reference values were defined influence individual biometrical parameters was...

Glucocorticoid (GC) therapy is recognized to be effective for the treatment of recurrent airway obstruction (RAO) in horses. Anti‐inflammatory properties GC are thought mediated by suppression inflammatory gene expression via inhibition transcription factors such as nuclear factor‐±B (NF‐±B) and activator protein‐1 (AP‐1). The purpose this study was evaluate effect low‐dose inhaled beclomethasone dipropionate injectable dexamethasone 21‐isonicotinate on clinical signs, pulmonary function,...

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