A5010017243- Neuroscience and Neuropharmacology Research
- Epilepsy research and treatment
- Neuroscience of respiration and sleep
- Memory and Neural Mechanisms
- Ion channel regulation and function
- Sleep and Wakefulness Research
- Neurotransmitter Receptor Influence on Behavior
- Metabolism and Genetic Disorders
- Diet and metabolism studies
- Parkinson's Disease Mechanisms and Treatments
- COVID-19 Clinical Research Studies
- Mitochondrial Function and Pathology
- Genetics and Neurodevelopmental Disorders
- SARS-CoV-2 and COVID-19 Research
- Pharmaceutical studies and practices
- Pharmacological Effects and Toxicity Studies
- Neurological disorders and treatments
- Neural dynamics and brain function
- Neuroendocrine regulation and behavior
- Forensic Toxicology and Drug Analysis
- Nanomaterials for catalytic reactions
- Pregnancy and Medication Impact
- Neuroscience and Neural Engineering
- Amino Acid Enzymes and Metabolism
- Nerve injury and regeneration
Marmara University
2016-2025
Weatherford College
2003
Most dorsal thalamic nuclei send axons to specific areas of the neocortex and sectors reticular nucleus; then sends reciprocal connections back same nucleus, directly as well indirectly through a relay in nucleus. This can be regarded 'canonical' circuit sensory thalamus. For pathways that link thalamus hippocampal formation, only few comparable have been described. The reuniens nucleus some its major cortical efferents formation. present study shows cells formation are retrogradely labelled...
The posterior hypothalamic nucleus has been implicated as an area controlling autonomic activity. afferent input to the will provide evidence its role in function. In present study, we aimed identify detailed anatomical projections from cortical, subcortical and brainstem structures, using horseradish peroxidase (HRP) retrograde axonal transport technique rat. Subsequent injection of HRP into nucleus, extensive cell labelling was observed bilaterally various areas cerebral cortex including...
This prospective observational study describes the pharmacokinetic characteristics of favipiravir in adult patients hospitalized for mild to moderate COVID‐19 with a positive RT‐PCR test. Favipiravir was administered 5 days, loading dose 3200 mg and maintenance 1200 mg/day. Serial blood samples were collected on Day 2 4 therapy. Laboratory findings ( n = 21) in‐hospital mortality recorded. concentrations exhibited substantial variability significant decrease during treatment COVID‐19. The...
The existence of absence epilepsy and temporal partial seizure pattern in the same patient is an uncommon state. In present study, we aimed to evaluate whether process kindling as a model complex seizures with secondary generalization altered rats genetic epilepsy.Six- 12-month-old nonepileptic control Wistar epileptic from Strasbourg (GAERS) were used experiments. One week before experiments, bilateral stimulation recording electrodes implanted stereotaxically into basolateral amygdala...
Spontaneous 7–10 Hz spike‐wave discharges (SWDs) are the electroencephalographic hallmark of absence seizures, as can be observed in WAG/Rij well GAERS, two commonly used well‐validated genetic rat models epilepsy. A local upregulation sodium channels within perioral region primary somatosensory cortex indicated an initiation site for SWDs rats, line with a new theory that assumes have cortical focal origin cortex. We tested whether bilateral microinfusion at this channel blocker phenytoin,...
We showed previously that genetic absence epilepsy rats from Strasbourg (GAERS) resist secondary generalization of focal limbic seizures after electrical kindling. now investigate the effect intra-amygdaloid injection kainic acid, as another model temporal lobe epilepsy, focusing on epileptogenesis, spike-and-wave discharges (SWDs), and transition basal to SWD states in GAERS. The EEG was recorded hippocampus cortex adult GAERS Wistar before acid injections into basolateral amygdala for 3...
Summary: The involvement of the thalamus in limbic epileptogenesis has recently drawn attention to connectivity between nuclei and structures. Thalamo‐limbic circuits are thought regulate seizure activity whereas thalamocortical involved expression generation spike‐and‐wave discharges (SWDs) absence epilepsy models. Genetic Absence Epilepsy Rats From Strasbourg (GAERS) WAG/Rij (Wistar Albino Glaxo from Rijswijk) well‐defined genetic animal models epilepsy. We aimed examine duration...
Objective: In epilepsy treatment, drugs that increase GABAergic and decrease glutamatergic activity, like sodium valproate, are used. Riluzole is a neuroprotective drug blocks neurotransmission potential with its anti-seizure effects. This study evaluates the effects of valproate riluzole on genetic absence rat from Strasbourg (GAERS) model individually combined. Materials Methods: Adult male GAERS rats (n = 22) were Rats administered 5/10 mg/kg riluzole, 150/300 95% ethanol, 5 combinations...
The stimulation or ablation of cerebellar structures has produced a variety visceral responses, indicating role in functions. Studies using anterograde and retrograde tracing methods have revealed connections between the hypothalamus structures. aim this study is to investigate dorsomedial (DMH) posterior hypothalamic nuclei axonal transport horseradish peroxidase (HRP). In present study, micro‐injection HRP restricted within borders DMH showed that projections nucleus are not uniform...
The posterior hypothalamic nucleus has been implicated as an area controlling autonomic activity. afferent input to the will provide evidence its role in function. In present study, we aimed identify detailed anatomical projections from cortical, subcortical and brainstem structures, using horseradish peroxidase (HRP) retrograde axonal transport technique rat. Subsequent injection of HRP into nucleus, extensive cell labelling was observed bilaterally various areas cerebral cortex including...
Summary: Purpose: The kindling model in rats with genetic absence epilepsy is suitable for studying mechanisms involved the propagation and generalization of seizure activity convulsive nonconvulsive components epilepsy. In present study, we compared amygdala rate afterdischarge characteristics nonepileptic Wistar control rat a well‐validated epilepsy, WAG/Rij rat, demonstrated effect on spike‐and‐wave discharges (SWDs) group. Methods: Electrodes were stereotaxically implanted into...
The stimulation or ablation of cerebellar structures has produced a variety visceral responses, indicating role in functions. Studies using anterograde and retrograde tracing methods have revealed connections between the hypothalamus structures. aim this study is to investigate dorsomedial (DMH) posterior hypothalamic nuclei axonal transport horseradish peroxidase (HRP). In present study, micro-injection HRP restricted within borders DMH showed that projections nucleus are not uniform...
Genetic absence epilepsy rats from Strasbourg (GAERS) are resistant to the progression of kindling seizures. We studied local cerebral blood flow (LCBF) changes in brain regions involved seizures both GAERS and nonepileptic (NEC) map differences that may be related resistance kindling.Electrodes were implanted amygdala adult NEC male rats, which stimulated reach stage 2. Quantitative autoradiographic measurements LCBF performed by [(14)C]-iodoantipyrine ([(14)C]IAP) technique allowing...
In utero irradiation models induce diffuse neuronal damage. Experimental studies have shown that hyperthermia induced seizures are easily elicited and high mortality accompanied by loss. Neuronal damage loss the results of cell death coupled with cortical development in altered cellular development. The aim study was to investigate changes hippocampus exposed hyperthermia.Four groups were studied: 1) group 225 cGy on 17th gestational day; 2) 10th postnatal 3) plus hyperthermia; 4) control...