A5083062583- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Neuroscience and Neuropharmacology Research
- Drug Transport and Resistance Mechanisms
- Metabolism and Genetic Disorders
- Antibiotics Pharmacokinetics and Efficacy
- Schizophrenia research and treatment
- Pharmaceutical studies and practices
- Pharmacogenetics and Drug Metabolism
- Diet and metabolism studies
- HIV/AIDS drug development and treatment
- Ion channel regulation and function
- Pharmacological Receptor Mechanisms and Effects
- Anesthesia and Sedative Agents
- Glycogen Storage Diseases and Myoclonus
- Drug-Induced Ocular Toxicity
- Electroconvulsive Therapy Studies
- Plant-based Medicinal Research
- Cannabis and Cannabinoid Research
- Oral and gingival health research
- Cancer Treatment and Pharmacology
- Alcoholism and Thiamine Deficiency
- Neurological Complications and Syndromes
- Pain Mechanisms and Treatments
- Analytical Chemistry and Chromatography
National Hospital for Neurology and Neurosurgery
2012-2023
University College London
2013-2023
Epilepsy Society
2010-2019
UCL Biomedical Research Centre
2016-2018
Epilepsy Research UK
1992-2016
Brown University
2013
University College Lahore
2013
UCL Australia
2008
Western Infirmary
2001
Transnational Press London
2000
Summary Although no randomized studies have demonstrated a positive impact of therapeutic drug monitoring (TDM) on clinical outcome in epilepsy, evidence from nonrandomized and everyday experience does indicate that measuring serum concentrations old new generation antiepileptic drugs (AEDs) can valuable role guiding patient management provided are measured with clear indication interpreted critically, taking into account the whole context. Situations which AED measurements most likely to be...
Carbon-11-labeled flumazenil combined with positron emission tomography (PET) was used to measure the concentration (Bmax) of benzodiazepine (Bz) receptor in brain and its equilibrium dissociation constant (KD) for five normal subjects. The steady-state approach injecting tracer as a bolus high specific activity. In each subject two studies were carried out. first study performed at essentially zero occupancy, alone study. second occupancy about 50%, achieved by prolonged infusion nonlabeled...
Summary Objective Given that only the free non–protein‐bound concentration of an antiepileptic drug ( AED ) crosses blood–brain barrier, entering brain and producing effect, knowledge measurement fraction is important. Such data are sparse, particularly for newer s, have arisen from use disparate methodologies settings over past six decades. We report on protein binding 25 s available clinical use, along with two pharmacologically active metabolites (carbamazepine‐epoxide N ‐desmethyl...
Trigeminal neuralgia is a recurrent severe shooting neuropathic pain which can be managed both pharmacologically and surgically. However, there are no prospective data that compare these two therapeutic strategies. This study therefore aimed to assess long-term outcome in patients with intractable trigeminal treated oxcarbazepine later surgery. Fifteen (11 females) available drugs (carbamazepine, phenytoin baclofen), were prospectively followed for 13 years (1986–1999) total follow up time...
Abstract: Marked abnormalities of the magnetic resonance intensity N ‐acetylaspartate (NAA) have been reported in patients with various neurological disorders, but neurochemical consequences these alterations are difficult to assess because function NAA remains speculative. The purpose this study was examine whether plays a role protecting neurons against osmotic stress. Intracerebral microdialysis used expose small region rat dorsolateral striatum an increasingly hyposmotic environment and...
The efficacy and tolerability of oxcarbazepine, a keto derivative carbamazepine, has been assessed in six patients (two males, four females; mean age 61 years, range 42-77), with trigeminal neuralgia refractory to carbamazepine therapy, over period 6 months. An excellent therapeutic response oxcarbazepine was seen all pain control correlating well serum drug concentrations its primary active metabolite 10-OH-carbazepine. Onset the effect observed within 24 hours cases. overall concentration...