A5065228486- Endometrial and Cervical Cancer Treatments
- Breast Cancer Treatment Studies
- Cancer Genomics and Diagnostics
- Nitric Oxide and Endothelin Effects
- Ovarian cancer diagnosis and treatment
- Molecular Biology Techniques and Applications
- Pancreatitis Pathology and Treatment
- Cervical Cancer and HPV Research
- Electrical and Bioimpedance Tomography
- Estrogen and related hormone effects
- Spaceflight effects on biology
- Thyroid Cancer Diagnosis and Treatment
- Genital Health and Disease
- Pharmacogenetics and Drug Metabolism
- Extracellular vesicles in disease
- Ocular Oncology and Treatments
- Genetic factors in colorectal cancer
- Caveolin-1 and cellular processes
- Nutrition and Health in Aging
- Cancer Research and Treatment
- Cancer and Skin Lesions
- Digital Imaging in Medicine
- 14-3-3 protein interactions
- Additive Manufacturing and 3D Printing Technologies
- Enzyme function and inhibition
Aberdeen Royal Infirmary
2023
Manchester Royal Infirmary
2009-2017
Manchester University NHS Foundation Trust
2013-2017
University of Manchester
2014
Manchester University
2014
Karolinska Institutet
2013
Newcastle University
1984-2009
Royal Victoria Infirmary
2004-2006
University Hospital of North Durham
2003-2006
Institute of Cancer Research
2005
Nitric oxide has been implicated as a mediator of inflammatory arthritis, and recent work shown that pro-inflammatory cytokines stimulate NO production in vitro by activation the inducible nitric synthase (iNOS) pathway. In order to identify cellular sources within joint, we have used immunohistochemical techniques study distribution iNOS synovium cartilage from normal diseased joints. was most strongly expressed synovial lining layer, subsynovium, vascular smooth muscle chondrocytes...
To study the role of nitric oxide (NO) derived from inducible synthase (iNOS) pathway in induction apoptosis rheumatoid joint.Joint tissue was obtained four arthritis (RA) patients, three osteoarthritis patients and two with a fractured neck femur (NOF#), apoptotic cells were identified cryosections using TUNEL (terminal dUTP nick end labelling) assay. Expression iNOS determined immunohistochemistry. NO synthesis effect NOS inhibitors on levels studied explant cultures RA cartilage...
Gene signatures and Ki67 stratify the same breast tumor into opposing good/poor prognosis groups in approximately 20% of patients. Given this discrepancy, we hypothesized that combination a clinically relevant signature IHC markers may provide more prognostic information than either classifier alone.
Although the clearance of many oxidized drugs falls with age, a corresponding fall in maximal activities drug metabolizing enzymes has not been noted. The possibility enzyme affinity for substrate which could account observed changes, previously investigated human liver. We have studied kinetics microsomal mono-oxygenase 7-ethoxycoumarin-O-de-ethylase 17 liver biopsy specimens. No correlation was between age and protein recovery, activity or apparent affinity. Since affinities appear to...
A significant proportion of the genes regulated by 17-beta-estradiol (E2) via estrogen receptor alpha (ERα) have roles in vesicle trafficking breast cancer. Intracellular and extracellular vesicles important tumourigenesis. Here we report discovery giant (3-42μm) intracellular (GVs) role E2 on formation cancer (BC) cell lines using three independent live imaging techniques. Large diameter vesicles, GVs were also identified a patient-derived xenograft BC model, invasive carcinoma tissue....
The plasma, in addition to the liver, is a major site of hydrolysis aspirin. Human plasma and liver aspirin esterase activities samples from group patients varied over two fold range there was significant correlation between individual activities. present cytosolic microsomal fractions. Cytosolic enzymes had different apparent affinities for
Objective To compare endoscopic ultrasound ( EUS) ‐ FNA C diagnosis of pancreatic lesions with patient outcome based upon the Papanicolaou Society Cytopathology pancreaticobiliary terminology classification scheme diagnostic categories: Panc 1 (non‐diagnostic); 2 (negative for malignancy/neoplasia); 3 (atypical); 4B (neoplastic, benign); 4O other); 5 (suspicious malignancy); and 6 (positive/malignant). Methods All EUS pancreas specimens taken at Manchester Royal Infirmary in 2015 were...
The manufacture and production of viscose rayon, acetate, nylon, polyester, acrylic, modacrylic, carbon, polyolefin, chlorofibers, alginate, poly(vinyl alcohol), elastomeric organic fibers are reviewed. Much attention is given also to modifications these their end uses. -- AATA
Two liquid-based cytology (LBC) systems are in widespread use the UK: ThinPrep® and SurePath®. A number of studies have now compared LBC with conventional cervical screening. However, to date, we aware no that SurePath® LBC. As selection specific diagnostic a laboratory has significant clinical economic implications, there is clear need compare directly existing technology. The objective this study was single using performance indicators.Data were collected for all samples processed at...
The inability to optimise stent expansion fully whilst simultaneously preventing distal embolisation during ST-elevation myocardial infarction (STEMI) remains a clinical conundrum. We aimed describe newly devised angiographic strategy of "forward" and "back" aspiration that leads more complete thrombus removal prevention embolisation, allow high-pressure post-dilatation the implanted be performed.Forward was conducted with conventional thrombectomy catheter, bail-out for angiographically...
Previous studies have shown that a decrease in red cell mass occurs astronauts, and some indicate leukocytosis occurs. A life science module housing young mature rats was flown on shuttle mission Spacelab 3 (SL-3), the results of hematology flight control are presented. Statistically significant increases hematocrit, blood counts, hemoglobin determinations, together with mild neutrophilia lymphopenia, were found animals. No changes bone marrow spleen differentials or erythropoietin...
1. Benorylate (4-acetamido phenyl-O-acetylsalicylate) hydrolysis in vitro by human plasma and liver microsomes cytosol has been investigated. 2. was hydrolysed a route involving initial of the acetyl group to yield phenetsal followed paracetamol salicylate. Hydrolysis via acetylsalicylate minor. 3. more actively than about 10 times faster plasma. 4. Following single oral dose benorylate (4 g) volunteers only salicylate were detected 5. The therapeutic effects appear be mediated paracetamol.