A5063514027- Advanced biosensing and bioanalysis techniques
- Nanocluster Synthesis and Applications
- Advanced Nanomaterials in Catalysis
- Carbon and Quantum Dots Applications
- Nanoplatforms for cancer theranostics
- Graphene and Nanomaterials Applications
- Luminescence and Fluorescent Materials
- Photochromic and Fluorescence Chemistry
- Electrochemical sensors and biosensors
- Supramolecular Chemistry and Complexes
- RNA Interference and Gene Delivery
- Boron Compounds in Chemistry
- Protease and Inhibitor Mechanisms
- Cell Adhesion Molecules Research
- Ferroptosis and cancer prognosis
- melanin and skin pigmentation
China University of Petroleum, East China
2018-2024
Nucleoli are important subnuclear structures inside cells. We report novel fluorescent gold nanoclusters (K–AuNCs) that able to stain the nucleoli selectively and make it possible explore nucleolar morphology with fluorescence imaging technique. This probe is prepared through an easy synthesis method by employing a tripeptide (Lys–Cys–Lys) as surface ligand. The properties, including deep-red emission (680 nm), large Stocks shift, broad excitation band, low cytotoxicity, good photostability,...
Intracellular protein delivery has the potential to revolutionize cell-biological research and medicinal therapy, with broad applications in bioimaging, disease treatment, genome editing. Herein, we demonstrate successful of a functional protein, cytochrome c (CYC), by using boron cluster anion as molecular carrier superchaotropic type (B 12 Br 11 OPr 2– ). CYC was delivered into lipid bilayer vesicles well living cells, cellular uptake ratio approaching 90%. Mechanistic studies showed that...
Abstract Assemblies of biopolymers and nanomaterials have become a powerful tool to build up new architectures with growing application potential. Herein, novel peptide‐stabilized fluorescent gold nanoclusters, K4‐AuNCs, are utilized as building blocks investigate their coassembly nucleic acids. K4‐AuNCs possess ultrasmall size (1.8 nm), red fluorescence emission, positively charged surfaces, which able coassemble DNA or RNA strands through electrostatic interactions form pitaya‐like hybrid...
Compared with primary and local tumor, metastasis is more difficult to resect completely remain the leading cause of death associated solid tumors. It therefore pressing develop effective strategies prevent suppress tumor in its early stages. Heparanase overexpression significantly increased malignancy metastasis. Here, we a novel heparanase degradable heparin-based microcarrier, HBMA, for specific staining, targeting, inhibiting cells high metastatic potential. HBMA fabricated through...
Abstract Fluorescent polymer nanoparticles (NPs) have great potential as bioimaging and therapeutic agents in the biomedical field. Here, a subtle method is developed to synthesize inherently fluorescent core–shell NPs with diameters less than 100 nm. The permanent fluorescence comes from rigid conjugated structure between benzene chloromethyl groups crosslinked poly(chloromethylstyrene) (PCMSt) core, which able be applied for determination of Fe 3+ detection limit 1.39 × 10 −6 m . It...