A5000116323- Cardiovascular Function and Risk Factors
- Cardiovascular Effects of Exercise
- Cardiac Imaging and Diagnostics
- Cardiovascular and exercise physiology
- Pulmonary Hypertension Research and Treatments
- Cardiac Valve Diseases and Treatments
- Cardiac pacing and defibrillation studies
- Cardiac Arrhythmias and Treatments
- Cardiac Structural Anomalies and Repair
- Cardiac Fibrosis and Remodeling
- Cardiomyopathy and Myosin Studies
- Cardiac electrophysiology and arrhythmias
- Heart Failure Treatment and Management
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Disease and Adiposity
- Infective Endocarditis Diagnosis and Management
- Acute Myocardial Infarction Research
- Sports Performance and Training
- Adipose Tissue and Metabolism
- Cardiac tumors and thrombi
- Exercise and Physiological Responses
- Protein Kinase Regulation and GTPase Signaling
- Metabolism, Diabetes, and Cancer
- Advanced MRI Techniques and Applications
- Atherosclerosis and Cardiovascular Diseases
Advanced Center for Chronic Diseases
2015-2025
Pontificia Universidad Católica de Chile
2015-2024
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2012-2019
Centro de Investigación Biomédica en Red
2019
Centro de Investigación en Red en Enfermedades Cardiovasculares
2019
Creative Research Enterprises (United States)
2018
Universitat de Barcelona
2012-2016
University of Chile
2014-2015
Hospital Clínic de Barcelona
2012-2014
University of Szeged
2013
Pathophysiology of heart failure (HF) with preserved ejection fraction (HFPEF) remains unclear. Left atrial (LA) function has been related to HF symptoms. Our purpose is analyse LA in outpatients new onset symptoms HF.An observational study was performed including 138 consecutive suspected referred a one-stop clinic. Final diagnosis [HF reduced EF (HFREF), HFPEF, or non-HF] established according current recommendations. Echocardiography all patients. analysed using strain derived from...
Background: Hypertrophic cardiomyopathy (HCM) is a common cause of sudden death in athletes and differentiating this condition from the nonpathological “athlete's heart” remains challenge. The development pathological left ventricular hypertrophy (LVH) associated with atrial (LA) dilatation dysfunction. LA strain rate by two‐dimensional (2D) speckle tracking are novel indices function might contribute to differentiate physiological LVH among underdiagnosed HCM. Methods: We evaluated 20...
Left atrial (LA) size has been related to the success of radiofrequency catheter ablation (RFCA) for fibrillation (AF). However, potential predictors after a repeated procedure are unknown. We evaluate predictive factors successful AF first and RFCA.A total 154 patients with were treated RFCA. LA function assessed three-dimensional echocardiography (3D Echo) before The effectiveness RFCA was evaluated 6 months. Recurrence arrhythmia defined as any documented (clinically or by 24-h Holter...
Abstract Heart failure (HF) with preserved ejection fraction (HFpEF) is a complex syndrome characterized by symptoms of HF despite normal left ventricular function. It now accounts for >50% all cases, the only effective treatment (morbidity benefit) so far being sodium‐glucose co‐transporter‐2 inhibitors, finerenone and tirzepatide. Recently, vascular dysfunction has been highlighted as one main pathophysiological mechanisms HFpEF. ‘two‐hit’ experimental model HFpEF was described in which...
Background: Even though atrial fibrillation (AF) is the most common arrhythmia after coronary artery bypass grafting (CABG), its etiology remains poorly understood. Several factors are linked to postoperative AF (POAF), including advanced age and systemic inflammation. However, left (LA) contractile dysfunction has not been evaluated in perioperative scenario. Aim: To evaluate LA function through strain rate patients with disease undergoing CABG correlation POAF. Methods: We studied 70 sinus...
There is experimental evidence on the role of Rho-kinase (ROCK) activation in cardiac hypertrophy but no information its human hypertension and left ventricular (LVH). We hypothesized that ROCK activity higher hypertensive patients with LVH compared without LVH. conducted a cross-sectional study comparing untreated (n = 41) 46) determined by echocardiography healthy normotensive control group 51). Measurements included LV mass, dimensions, function circulating leukocytes measuring Western...
Highly trained athletes show an increased risk of atrial arrhythmias. Little is known about volumes and function during exercise in this population. Our aim was to analyze size contractile exercise. Fifty endurance with 11 ± 8 h training per week 30 sedentary control subjects were included. Echocardiography performed at baseline Left (LA) right (RA) assessed by two-dimensional echocardiography. Peak negative strain (Sa) contraction active emptying volume (AEV) measured. Athletes showed a...
Abstract Background: High‐intensity training has been associated with atrial remodelling and arrhythmias in men. Our purpose was to analyse performance female endurance athletes, compared male athletes controls. Methods: This a cross‐sectional study. We included four groups: females controls, Left (LA) right (RA) volumes function were assessed using 2D speckle‐tracking echocardiography determine peak strain‐rate at (SRa) ventricular contraction (SRs), as surrogates of contractile reservoir...
Pulmonary artery hypertension (PAH) is a chronic and progressive disease. Although current therapy has improved the disease prognosis, PAH poor survival rate. The key feature leading to progression death right ventricular (RV) failure.We assessed role of trimetazidine, fatty acid beta-oxidation (FAO) inhibitor, in function, remodeling, functional class patients, with placebo-controlled double-blind, case-crossover trial. Twenty-seven subjects were enrolled, randomized, assigned trimetazidine...
Objective Advanced age is an independent predictor of postoperative atrial fibrillation ( POAF ) in patients undergoing coronary artery bypass surgery. We evaluated whether left LA dysfunction assessed by strain contributes to identifying elderly prone . Methods Case–control study 70 subjects Clinical and laboratory characteristics were recorded at baseline 72 hours after Echocardiography was performed during the preoperative period; dimensions deformation (systolic wave [ LAS s]) as well...
This study assessed the intra-individual reliability of oxygen saturation in intercostal muscles (SmO2-m.intercostales) during an incremental maximal treadmill exercise by using portable NIRS devices a test-retest study. Fifteen marathon runners (age, 24.9 ± 2.0 years; body mass index, 21.6 2.3 kg·m−2; V̇O2-peak, 63.7 5.9 mL·kg−1·min−1) were tested on two separate days, with 7-day interval between measurements. Oxygen consumption (V̇O2) was breath-by-breath method V̇O2-test, while SmO2...
Respiratory muscle training (RMT) improves physical performance, although it is still debated whether this effect depends on the type of training. The purpose study was to compare effects two different types RMT, i.e., voluntary isocapnic hyperpnea (VIH) and inspiratory threshold loading (ITL), deoxygenation intercostal (ΔSmO2-m. intercostales) vastus lateralis lateralis) muscles during exercise. Twenty-four participants performed eight weeks RMT by: (i) VIH (3 days·week-1 for 12 min at 60%...