A5065524576- Sphingolipid Metabolism and Signaling
- Lysosomal Storage Disorders Research
- Lipid Membrane Structure and Behavior
- Phytochemicals and Antioxidant Activities
- Migraine and Headache Studies
- Erythrocyte Function and Pathophysiology
- Meat and Animal Product Quality
- Vitamin D Research Studies
- Cellular transport and secretion
- Animal Nutrition and Physiology
- Nuclear Structure and Function
- Eating Disorders and Behaviors
- Sirtuins and Resveratrol in Medicine
- Antioxidant Activity and Oxidative Stress
- Rabbits: Nutrition, Reproduction, Health
- Probiotics and Fermented Foods
- Cancer, Lipids, and Metabolism
- Essential Oils and Antimicrobial Activity
- Advanced Chemical Sensor Technologies
- Diet and metabolism studies
- Vitamin C and Antioxidants Research
- Parkinson's Disease Mechanisms and Treatments
- Carbohydrate Chemistry and Synthesis
- Obsessive-Compulsive Spectrum Disorders
- Fibroblast Growth Factor Research
University of Perugia
2016-2025
Despite evidence emerging from the experimental model of nitroglycerin-induced headache, endogenous increase in nitric oxide (NO) production during migraine attacks is only speculative. It has been hypothesized that there a close relationship between activation L-arginine/NO pathway and certain vasoactive algogenic prostaglandins spontaneous attacks, but this suggestion also needs to be confirmed. In present study levels nitrites, stable metabolites NO, were determined with high performance...
We measured, by RIA methods, ictal and interictal levels of substance P (SP), calcitonin-gene related peptide (CGRP) neurokinin A (NKA) in the plasma 30 young migraine patients with aura (MPA) 45 without (MWA), compared results those age-matched controls. There were no significant differences between these vasoactive peptides control group both groups studied headache-free periods. An elevation CGRP was found during attacks MPA and, to a lesser extent, MWA (p < 0.03 p 0.05, respectively)....
This study illustrates the sensing and wound healing properties of silk fibroin in combination with peptide patterns, an emphasis on printability multilayered grids, envisions possible applications these next-generation silk-based materials. Functionalized fibers covalently linked to arginine-glycine-aspartic acid (RGD) create a platform for preparing biomaterial ink 3D printing grid-like piezoresistors wound-healing properties. The culture medium obtained from 3D-printed enriched RGD...
In this study, we analyzed the neuroprotective action of silk fibroin (SF) regenerated with calcium chloride (CaCl2), distinguishing effects CaCl2 and SF, subsequently fabricating a hybrid material based on SF gelatin film. Cytotoxicity induced by 6-hydroxydopamine (6-OHDA) human neuroblastoma SH-SY5Y cell line showed that had significant shielding power against (6-OHDA)-induced neurotoxicity in cells, as assessed CCK-8 assay, imaging cycle using flow cytometer. Specifically, concurrent...
Abstract The aim of this work was to study the effect rosemary leaf dietary supplementation on antioxidant activities and total phenolic content Pecorino cheese. Three hundred twenty-four sheep were randomly assigned two groups, which received a standard diet based lucerne hay concentrate (400 g per day). supplemented group contained 2.50% dried leaves. trial lasted 7 weeks. Cheesemaking performed 3, 5 weeks from start trial. cheese activity modified by diet. Rosemary increased content,...
Neuroinflammation is a feature of many classic neurodegenerative diseases. In the healthy brain, microglia cells are distributed throughout brain and constantly surveilling central nervous system (CNS). response to CNS injury, quickly react by secreting wide array apoptotic molecules. Virgin olive oil (VOO) universally recognized as symbol Mediterranean diet. current study, using lipopolysaccharide (LPS)-stimulated BV2 microglia, anti-inflammatory effects VOO phenolic extracts from Moraiolo...
Abstract Background In the past two decades, sphingolipids have become increasingly appreciated as bioactive molecules playing important roles in a wide array of pathophysiology mechanisms. Despite advances field, nutrients remain little explored. Today research is starting to move towards study sphingomyelin content human breast milk, recommended for feeding infants. Methods present study, we performed lipidomic analysis milk relation with maternal diet during pregnancy, infant formulas,...
Lycium barbarum is a famous plant in the traditional Chinese medicine. The known to have health-promoting bioactive components. properties of berries cultivated Umbria (Italy) and their effect on human hepatocellular carcinoma cells (HepG2) been investigated this work. obtained results demonstrated that from region display high antioxidant evaluated by total phenolic content ORAC method, hydrophilic lipophilic fractions. Moreover, HepG2 cell line extract did not change viability analyzed MTT...
Lipid microdomains localized in the inner nuclear membrane are considered platforms for active chromatin anchoring. Stimuli such as surgery, vitamin D, or glucocorticoid drugs influence their gene expression, DNA duplication, and RNA synthesis. In this study, we used ultrafast liquid chromatography-tandem mass spectrometry to identify sphingomyelin (SM) species coupled with immunoblot analysis comprehensively map differences lipid (NLMs) purified from hepatocytes hepatoma cells. We showed...
Resveratrol, because of its low solubility in water and high membrane permeability, is collocated the second class biopharmaceutical classification system, with limited bioavailability due to dissolution rate. Solid dispersion resveratrol supported on Magnesium DiHydroxide (Resv@MDH) was evaluated improve increase resveratrol. Fluorimetric microscopy analysis displays three types microparticles similar size: Type 1 that emitted preferably fluorescence at 445 nm bandwidth 50 nm, type 2 605 70...
Pomegranate pulp, a by-product of the pomegranate juice industry, contains remarkable quantity bioactive compounds that can favorably affect ruminant metabolism and milk quality. The present paper investigated effect dietary pulp on yield quality during late lactation in grazing ewes. Twenty Comisana ewes (150 ± 10 days milk) were subdivided into control (CTRL) (PP) groups. CTRL group received corn-barley based concentrate, while PP concentrate containing 64.8% pulp. Dietary treatment did...
ω-3 Polyunsaturated fatty acids (PUFAs) have been found to exert many actions, including neuroprotective effects. In this regard, the exact molecular mechanisms are not well understood. Parkinson's disease (PD) is second most common age-related neurodegenerative disease. Emerging evidence supports hypothesis that PD result of complex interactions between genetic abnormalities, environmental toxins, mitochondrial dysfunction, and other cellular processes, such as DNA methylation. context,...
In the last decade, cholesterol level has been implicated in several types of cancer, including breast cancer. current study, we aimed to investigate condition lipid depletion, hypocholesterolemia or hypercholesterolemia reproduced vitro analyze response different human cancer cells. Thus, MCF7 as luminal A model, MB453 HER2 model and MB231 triple-negative were used. No effect on cell growth viability was detected cells, (1) reduced growth, Ki67 expression; (2) increased ER/PgR (3)...
Pumpkin (Cucurbita sp.) represents an unquestionable source of valuable nutrients and bioactive compounds having a broad spectrum health-promoting effects. The goal this work was to characterize the byproducts (peels filaments) different pumpkin varieties belonging C. moschata (Butternut, Lunga di Napoli, Moscata Provenza, Violina rugosa) maxima (Delica, Delica vanity, Hokkaido, Mantovana) species in terms total carotenoid content, antioxidant activity, profiling. research revealed that...
Diet and obesity are recognized in the scientific literature as important risk factors for cancer development progression. Hypercholesterolemia facilitates lymphoma lymphoblastic cell growth time turns hypocholesterolemia that is a sign of tumour The present study examined how where cholesterol acts cells when you reproduce vitro an vivo hypercholesterolemia condition. We used non-Hodgkin's T human (SUP-T1 line) we studied morphology, aggressiveness, gene expression antioxidant proteins,...
Abstract Evidence from family and twin studies points to a genetic contribution the etiology of eating disorders (EDs), confirmed by association several single nucleotide polymorphisms (SNPs) with this group disorders. Previous reports have suggested that serotonin receptor ( 5‐HT2AR ) brain‐derived neurotrophic factor BDNF genes could be both involved in EDs susceptibility. In order provide further evidence about such association, we focused our attention on two SNPs located these carrying...
Nitric oxide (NO) in platelets has been proposed as a promising tool for studying NO variations migraine. In the present research platelet response to collagen and basal collagen-induced production of cGMP cytosol were assessed migraine patients (25 with aura 35 without aura) both interictally ictally, compared same parameters 30 age-matched control subjects. A reduced responsiveness was found patients, particularly those aura, this more marked during attacks (ANOVA interictal periods:...