A5026695278- Vitamin D Research Studies
- Urban Green Space and Health
- Land Use and Ecosystem Services
- Vitamin C and Antioxidants Research
- Peroxisome Proliferator-Activated Receptors
- Sleep and Wakefulness Research
- Urban Heat Island Mitigation
- Maternal Mental Health During Pregnancy and Postpartum
- Urban Agriculture and Sustainability
- Cancer, Lipids, and Metabolism
- Cancer, Hypoxia, and Metabolism
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Olfactory and Sensory Function Studies
- Bioactive Compounds and Antitumor Agents
- Sphingolipid Metabolism and Signaling
- Vagus Nerve Stimulation Research
University of Perugia
2023-2025
University of Bologna
2023
Ceramide is a critical molecule in both the physiology and pathology of central nervous system. The most studied aspect its effect on embryonic/stem cells. A salient question whether low doses ceramide induce neuronal differentiation without interfering with sphingolipid metabolism high can be used glioblastoma for their cytotoxic effect. Here, we examined dose (13 µM) HN9.10e Interestingly, 13 µM induced an immediate increase cell viability, followed by number mitochondria. Microscopic...
Sphingomyelin is a crucial molecule in the sphingolipid metabolic pathway, and its action closely related to that of vitamin D3. Both molecules are recognized for their involvement brain pathophysiology. In this study, effect sphingomyelin + D3-enriched diet was investigated rabbits. The results showed strong immunopositive GFAP staining brain’s white matter. Furthermore, remodeling balance between glycero-phospholipids ether-phospholipids observed brain, along with an increase ceramides...
Exosomes are well established effectors of cell-cell communication. Their role on maturation embryonic cells located in hippocampus, seat memory, is unknown. Here we show that ceramide facilitates release exosomes from HN9.10e extending information for cell differentiation to neighboring cells. We found only 38 miRNAs differentially expressed derived ceramide-treated comparison with control (including 10 up-regulated and 28 down-regulated). Some overexpressed (mmu-let-7f-1-3p,...
In the last decade, cholesterol level has been implicated in several types of cancer, including breast cancer. current study, we aimed to investigate condition lipid depletion, hypocholesterolemia or hypercholesterolemia reproduced vitro analyze response different human cancer cells. Thus, MCF7 as luminal A model, MB453 HER2 model and MB231 triple-negative were used. No effect on cell growth viability was detected cells, (1) reduced growth, Ki67 expression; (2) increased ER/PgR (3)...
The role of sphingomyelin metabolism and vitamin C in cancer has been widely described with conflicting results ranging from a total absence effect to possible preventive and/or protective effects. aim this study was establish the involvement changes induced by breast cells. MCF7 cell line reproducing luminal A MDA-MB-231 triple-negative were used. Cell phenotype tested estrogen receptor, progesterone human epidermal growth factor receptor 2 expression, proliferation index percentage....
Several single nucleotide polymorphisms (SNPs) of the vitamin D receptor (VDR) have been observed in association with susceptibility to various pathologies, including autism, major depression, age-related changes cognitive functioning, and Parkinson’s Alzheimer’s diseases. This study aimed establish between Fok1/Apa1 polymorphic variants anxious/depressive symptoms nonclinical adolescents from central Italy, goal identifying risk developing both symptoms. We found no significant difference...
Background: Persistent alterations in taste and smell affect a significant proportion of individuals following COVID-19, representing component post-acute COVID-19 syndrome, commonly referred to as long COVID. The degradation sphingomyelin by acid sphingomyelinase is regarded biomarker for acquired demyelinating neuropathies. Objectives: This study was aimed enroll women who contracted during pregnancy experienced persistent and/or more than 1 year post-infection, comparison pregnant without...
The effect of the antioxidant vitamin C in cancer has been studied for over 30 years with conflict-ing results ranging from total absence effect, to possible protective potential therapeutic when administered high doses. aim study was define breast and involvement sphingomyelin metabolism. Therefore, low dose on cells reproducing luminal A type (MCF7) triple negative (MB231) analyzed. showed that produced effects only MCF7 such as decreased cell viability, modulation cycle re-lated genes,...
In Europe, more than two-thirds of the population live in urban areas. The management green areas and trees is becoming increasingly relevant involving different players stakeholders, as well for keeping a focus on Sustainable Development Goals. Society policy makers are often unaware disservices that neglecting these can cause. Appropriate monitoring interventions protect both citizens themselves. aim study was to assess risk potential Bologna suburbs (Italy). For each tree city Bologna,...
ISHS VIII International Conference on Landscape and Urban Horticulture trees felling failures: preliminary results from an investigation urban green infrastructure  locating the most sensitive species defining causes