A5041111533- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Cutaneous Melanoma Detection and Management
- CRISPR and Genetic Engineering
- Neuroendocrine Tumor Research Advances
- Lung Cancer Research Studies
- Insect Resistance and Genetics
- Cancer Cells and Metastasis
- Bladder and Urothelial Cancer Treatments
- Epigenetics and DNA Methylation
- Sarcoma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- RNA and protein synthesis mechanisms
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Genomics and Chromatin Dynamics
- Esophageal Cancer Research and Treatment
- Fungal and yeast genetics research
- Renal cell carcinoma treatment
Dana-Farber Cancer Institute
2022-2025
Harvard University
2022-2024
Broad Institute
2022-2024
Neuroendocrine tumors (NETs) are rare cancers that most often arise in the gastrointestinal tract and pancreas. The fundamental mechanisms driving gastroenteropancreatic (GEP)-NET growth remain incompletely elucidated; however, heterogeneous clinical behavior of GEP-NETs suggests both cellular lineage dynamics tumor microenvironment influence pathophysiology. Here, we investigated single-cell transcriptomes immune cells from patients with NETs. Malignant GEP-NET expressed genes regulons...
Sarcomas are rare connective tissue cancers thought to arise from aberrant mesenchymal stem cell (MSC) differentiation. Liposarcoma (LPS) holds valuable insights into dysfunctional differentiation given its well- and dedifferentiated histologic subtypes (WDLPS, DDLPS). Despite well-established differences in histology clinical behavior, the molecular pathways underlying each subtype poorly understood. Here, we performed single-nucleus multiome sequencing spatial profiling on carefully...
Abstract Sarcomas are rare connective tissue cancers thought to arise from aberrant mesenchymal stem cell (MSC) differentiation. Liposarcoma (LPS) is among the most common types of adult sarcoma and holds valuable insights into dysfunctional differentiation given its well- de-differentiated histologic subtypes (WDLPS DDLPS, respectively). Despite well-established differences in histology clinical behavior, molecular pathways underlying each subtype poorly understood, limiting therapeutic...
The diversity of structural variants (SVs) in melanoma and how they impact oncogenesis are incompletely known. We performed harmonized analysis SVs across histological genomic subtypes, we identified distinct global properties between subtypes. These included the frequency size SV classes, their relation to chromothripsis events, role topologically associated domain (TAD) boundary altering on cancer-related genes. Following our prior identification double-stranded break repair deficiency a...
Esophageal adenocarcinoma (EAC) is a highly lethal cancer of the upper gastrointestinal tract with rising incidence in western populations. To decipher EAC disease progression and therapeutic response, we performed multiomic analyses cohort primary metastatic tumors, incorporating single-nuclei transcriptomic chromatin accessibility sequencing, along spatial profiling. We identified tumor microenvironmental features previously described to associate therapy response. five malignant cell...
Abstract Background: Cisplatin-based chemotherapy followed by radical cystectomy remains the standard-of-care treatment for patient with localized muscle-invasive bladder cancer (MIBC). Neoadjuvant clinical trials studying combination of cisplatin-based and immune checkpoint blockade (ICB) in MIBC reported encouraging pathologic complete response rates. However, molecular mechanisms cellular programs involved resistance to cisplatin ICB remain incompletely characterized. Our goal is define...
ABSTRACT Renal cell carcinoma (RCC) is characterized by recurrent somatic mutations in epigenetic regulators, which stratify patients into clinically significant subgroups with distinct prognoses and treatment responses. However, the type-specific landscape of RCC—broadly context these mutations—is incompletely understood. To investigate open questions, we integrated single nucleus ATAC sequencing data from RCC tumors across four independent cohorts. In clear tumors, identified shared...
ABSTRACT Neuroendocrine tumors (NETs) are rare cancers that may arise in the gastrointestinal tract and pancreas. The fundamental mechanisms driving gastroenteropancreatic (GEP) NET growth remain incompletely elucidated; however, heterogeneous clinical behavior of GEP-NETs suggests both cellular lineage dynamics tumor microenvironment influence pathophysiology. Here, we investigated single-cell transcriptomes immune cells from patients with NETs. Malignant GEP-NET expressed genes regulons...
Abstract The diversity of structural variants (SVs) in melanoma and how they impact oncogenesis are incompletely known. We performed harmonized analysis SVs across histological genomic subtypes, we identified distinct global properties between subtypes. These included the frequency size SV classes, their relation to chromothripsis events, role topologically associated domain (TAD) boundary altering on cancer-related genes. Following our prior identification double-stranded break repair...
Abstract Aspergillus nidulans snxA, an ortholog of Saccharomyces cerevisiae Hrb1/Gbp2 messenger RNA shuttle proteins, is—in contrast to budding yeast—involved in cell cycle regulation, which snxA1 and snxA2 mutations as well a snxA deletion specifically suppress the heat sensitivity regulators CDK1 mitotic induction pathway. are strongly cold sensitive, at permissive temperature mRNA protein expression repressed. Initial attempts identify causative revealed no defects SNXA protein. Here, we...