A5100759356- Ferroelectric and Piezoelectric Materials
- Microwave Dielectric Ceramics Synthesis
- Quinazolinone synthesis and applications
- Synthesis and biological activity
- Chemical Synthesis and Analysis
- Multiferroics and related materials
- Click Chemistry and Applications
- Multicomponent Synthesis of Heterocycles
- High voltage insulation and dielectric phenomena
- Synthesis and Biological Evaluation
- Electronic and Structural Properties of Oxides
- Thermal Analysis in Power Transmission
- Neural Networks and Reservoir Computing
- Cancer therapeutics and mechanisms
- Polymer Nanocomposites and Properties
- Acoustic Wave Resonator Technologies
- Silicon Nanostructures and Photoluminescence
- HVDC Systems and Fault Protection
- Phenothiazines and Benzothiazines Synthesis and Activities
- Synthesis and Characterization of Pyrroles
- Advanced Memory and Neural Computing
- Toxin Mechanisms and Immunotoxins
- Metabolomics and Mass Spectrometry Studies
- High-Voltage Power Transmission Systems
- Synthesis and bioactivity of alkaloids
Kyungpook National University
2015-2025
Korea Electronics Technology Institute
2018
Korea Research Institute of Standards and Science
2016
Chungbuk National University
2016
Gyeongsang National University
2013-2014
Korea Research Institute of Chemical Technology
2009-2011
Dongguk University
2009-2010
Sogang University
2009
Seoul National University
2003-2004
A thiazolo-pyrimidinone derivative library was developed through a facile solid-phase synthesis method. For the reaction, thiazolo[4,5-d]pyrimidin-7(6H)-one structure synthesized efficient Thorpe–Ziegler and cyclization reactions. The with diversity of three had total four steps 57 compounds. In addition, yield per step 65–97%, which very high. method compounds will be used to find biological activity thiazole structure–activity relationship.
The solid-phase synthesis method is optimized for building chemical libraries. Furthermore, libraries are essential tools in drug discovery used to identify hit compounds. We constructed a 5H-thiazolo[5',4':5,6]pyrido[2,3-b]indole derivative library using synthesis. indole insertion reaction at the benzylic position Lewis acid and oxidative cyclization iodine were Using solution-phase conditions, comprising total of eight steps was employed build library. In addition, we found an efficient...
Traceless solid-phase synthesis of 2,5,6,7-tetrasubstituted thiazolo[4,5-b]pyridine derivatives is described. Thorpe−Ziegler type cyclization solid supported cyanocarbonimidodithioate with α-halo ketones afforded thiazole resin, which were converted to the desired thiazolopyridine resin by Friedländer protocol under microwave irradiation conditions. After oxidation sulfides sulfones, nucleophilic desulfonative substitution amines gave target in good overall yields.
An expedient, traceless, solid-phase synthesis of 2,4,6-trisubstituted thiazolo[4,5-d]pyrimidine-5,7-dione derivatives has been developed. The synthetic route utilizes urea formation by a microwave irradiation promoted reaction thiazole amino ester resin with an isocyanate. resulting is converted to thiazolopyrimidinedione resin, containing two diversity elements at N-4 and N-6, using one-pot cyclization/N-alkylation process. After oxidation form sulfone, nucleophilic C-2 substitution...
A new solid-phase route for preparation of 1,3,6-trisubstituted-1H-thiazolo[4,5-c][1,2]thiazin-4(3H)one-2,2-dioxide derivatives is described. Our synthetic begun with a thiazole resin and relies on the sulfonamide formation, Mitsunobu-type N-alkylation, cyclization, nucleophilic substitution methodology cleavage solid support. The strategy permits incorporation three points diversity into thiazolo[4,5-c][1,2]thiazine ring system in good overall yields.
Traceless solid-phase synthesis of 1,3,7,8-tetrasubstituted xanthine (1,3,7,8-tetrasubstituted 1H-purine-2,6(3H,7H)-dione) derivatives has been developed. The synthetic route began on a solid supported N'-cyano-N-substituted carbamimidothioate, which was prepared from cyanamide, isothiocyanate, and Merrifield resin. After N-alkylation carbamimidothioate resin with ethyl 2-bromoacetate, an imidazole ring is introduced by Thorpe-Ziegler-type cyclization. resulting converted to...
Efficient synthetic routes for the preparation of secondary and tertiary 1,2,3-triazoloamide derivatives were developed. A α-1,2,3-triazoloamide library was constructed expanded by a previously developed solid-phase route parallel solution-phase route. The rely on amide formation with amines chloro-acid chlorides; SN2 reaction sodium azide; selective [3 + 2] Hüisgen cycloaddition appropriate terminal alkynes. target obtained three-diversity points in excellent overall yields purities using...
In this study, lead-free (Na<sub>0.5</sub>K<sub>0.5</sub>)NbO<sub>3</sub>-BiTiO<sub>3</sub> ceramics were fabricated by a conventional mixed oxide method. Structural and electrical properties of (Na<sub>0.5</sub>K<sub>0.5</sub>)NbO<sub>3</sub> with the variation BiTiO<sub>3</sub> investigated. The results X-ray diffraction analysis showed typical polycrystalline perovskite structure without presence second phase in all specimens. Sintered density increased an increasing BTO specimen added...
High-resolution quadrupole-Orbitrap mass spectrometry (HRMS), with high-resolution (> 10,000 at full-width half-maximum) and accurate (< 5 ppm deviation) capabilities, plays an important role in the structural elucidation of drug metabolites pharmaceutical industry. ML106, a derivative imidazobenzimidazole, decreased melanin content tyrosinase activity dose-dependent manner. Here, we investigated phase 1 metabolic pathway ML106 using HRMS human liver microsomes (HLMs) recombinant...
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Abstract For see ChemInform in Full Text.
In this study, lead-free Piezoelectric <TEX>$(Na_{0.47}K_{0.47}Sr_{0.03}Ca_{0.03})(Nb_{0.94}Ti_{0.06})O_3$</TEX>-0.1 <TEX>$MnO_2$</TEX> ceramics were fabricated using mixed oxide method and the effects of various sintering temperature on structural electrical properties investigated. For (NKN-SCT-<TEX>$MnO_2$</TEX>) sintered at temperatures <TEX>$1,025{\sim}1,100^{\circ}C$</TEX>. The results indicated that all specimens perovskite single phase formation without any second phase. It has been...
We study the magnetoconductance and dephasing in a strongly localized regime black phosphorus (BP) devices. The phase coherence length, l φ obtained from follows temperature dependence of T –1/3 with k F e < 1 ( ξ ) based on Ioffe–Regel criterion. Here , are Fermi wave vector, mean free path localization respectively. conductance behavior as function confirms that transport our BP is variable‐range‐hopping regime, which results regime.
In this study, we fabricated anodic aluminum oxide (AAO) membrane by two step anodizing process for pH detection. The structural properties were observed X-ray diffraction (XRD) and field emission scanning electron microscope (FE-SEM). Electrochemical measurements of the sensor have been performed in capacitance-voltage (C-V) drift rates. characterization AAO exhibited high sensitivity (99.1 mV/pH) at second time 4 min.
In this study, lead-free <TEX>$(Na_{0.465}K_{0.465}Bi_{0.07})(Nb_{0.93}Ti_{0.07})O_3-0.08MnO_2$</TEX> ceramics were fabricated by conventional mixed oxide method. Structural and electrical properties of with the variation sintering temperature investigated. As results x-ray diffraction analysis, all specimens showed a typical polycrystalline perovskite structure without presence second phase. Sintered density increased an increases specimen sintered at <TEX>$1,020^{\circ}C$</TEX> maximum...
is the most commonly used insulating gas in electrical systems. But In these days mixtures and alternative has been studied because of global warming. so although many studies have carried out about binary with , few were presented breakdown characteristics mixtures. At present study Non-uniform field was performed. this paper, The simulation value are compared experiment values. Streamer criterion for predicting voltage. For accurate apply utilization factor using CST(computer technology)...