A5100776005- Metabolomics and Mass Spectrometry Studies
- Tryptophan and brain disorders
- Korean Urban and Social Studies
- Stress Responses and Cortisol
- Molecular Biology Techniques and Applications
- Bipolar Disorder and Treatment
- Mast cells and histamine
- Phosphorus and nutrient management
- Allergic Rhinitis and Sensitization
- Forensic Entomology and Diptera Studies
- Fish Biology and Ecology Studies
- Advanced Causal Inference Techniques
- Forensic and Genetic Research
- Asthma and respiratory diseases
- Traditional Chinese Medicine Studies
- Microbial Metabolic Engineering and Bioproduction
- Urban and spatial planning
- Forensic Fingerprint Detection Methods
- Synthetic Organic Chemistry Methods
- Quinazolinone synthesis and applications
- Heavy Metal Pollution Remediation
- Sulfur-Based Synthesis Techniques
- Regional Development and Environment
- Heavy metals in environment
- Sphingolipid Metabolism and Signaling
Eulji University
2020-2024
Korea Research Institute for Human Settlements
2023
Seoul National University
2022
Daegu-Gyeongbuk Medical Innovation Foundation
2022
Kyungpook National University
2015
Gyeongsan Science High School
2012-2014
Dong-Eui University
2010-2012
Inje University
2003
Korea Pharma (South Korea)
2003
Hannam University
2003
Abstract In patients with major depressive disorder, various functional areas are impaired, negatively impacting the quality of life. Remission can restore pre-depression functions; however, some may still have residual impairments. Distinguishing between near-normal recovery and impairment helps identify those at a high risk relapse tailor treatment. Accordingly, we aimed to discover validate biomarkers that distinguish in remission states through serum proteome analysis. Pooled individual...
Traceless solid-phase synthesis of 1,3,7,8-tetrasubstituted xanthine (1,3,7,8-tetrasubstituted 1H-purine-2,6(3H,7H)-dione) derivatives has been developed. The synthetic route began on a solid supported N'-cyano-N-substituted carbamimidothioate, which was prepared from cyanamide, isothiocyanate, and Merrifield resin. After N-alkylation carbamimidothioate resin with ethyl 2-bromoacetate, an imidazole ring is introduced by Thorpe-Ziegler-type cyclization. resulting converted to...
Metabolomic research using analytical chemistry methods has been carried out in a wide range of fields. However, combining forensic science and metabolomics is rare. Determining the age bloodstains could provide key information regarding when crime was committed. Currently, validated for estimating are unavailable. Metabolites intermediate final products chemical reactions. Therefore, they less likely to be degraded than other components blood under field conditions. In this study,...
Abstract Aim This study aimed to discover serum metabolite biomarkers for potential use in screening rheumatoid arthritis (RA). Methods The sera from 43 healthy controls (HCs) and 49 RA patients were globally analyzed using high‐performance liquid chromatography‐ tandem mass spectrometry. Molecular features (MFs) samples volcano plots, partial least squares discriminant analysis, variable importance projection scores select candidates. spectra of candidate MFs matched with the METLIN...
Major depressive disorder (MDD) exhibits a recurrence rate of up to 70%. Frequent can lead chronic depression, which has considerable personal and societal consequences. This study aims identify serum protein biomarker predict MDD progression chronicity.
Efficient synthetic routes for the preparation of secondary and tertiary 1,2,3-triazoloamide derivatives were developed. A α-1,2,3-triazoloamide library was constructed expanded by a previously developed solid-phase route parallel solution-phase route. The rely on amide formation with amines chloro-acid chlorides; SN2 reaction sodium azide; selective [3 + 2] Hüisgen cycloaddition appropriate terminal alkynes. target obtained three-diversity points in excellent overall yields purities using...
Four new acetylenic acids were isolated from the marine sponge Stelletta sp. by bioactivity-guided fractionation. The planar structures established on basis of NMR and MS analysis. stereochemistry was defined combined use CD spectroscopy a chiral anisotropic reagent, phenylglycine methyl ester (PGME). compounds evaluated for cytotoxicity against small panel five human tumor cell lines exhibited marginal to moderate cytotoxicity.
Major depressive disorder (MDD) is one of the most common psychiatric disorders that accompany psychophysiological and mood changes. However, pathophysiology-based disease mechanism MDD not yet fully understood, diagnosis also conducted through interviews with clinicians patients. Diagnosis treatment are limited due to absence biomarkers underlying pathophysiological mechanisms MDD. Although various attempts have been made discover metabolite for response MDD, problems sample size...
Bloodstain age estimation involves measuring time-dependent changes in the levels of biomolecules bloodstains. Although several studies have identified bloodstain metabolites as markers for estimating age, none considered sex, age-related metabolomic differences, or long-time age. Therefore, we aimed to identify metabolite bloodstains at weekly intervals within 28 days and validate them through multiple reaction monitoring. Adenosine 5'-monophosphate, choline, pyroglutamic acid were selected...
Purpose: Depressive mood is a major psychiatric symptom that causes serious disturbances in daily life. Unlike physical symptoms, symptoms are more difficult to evaluate objectively. Therefore, we aimed discover biomarkers reflect changes serum protein metabolism during clinical depressive mood. Methods: Serum profiling was conducted participants who were not experiencing current episode (healthy individuals and patients remission). proteins identified quantified using liquid...
Ergothioneine, which is a naturally occurring metabolite, generally accumulates in tissues and cells subjected to oxidative stress, owing its structural stability at physiological pH; therefore, it has been attracting attention various biomedical fields. Ergothioneine also suggested as potential forensic marker, but applicability not yet quantitatively validated. In this study, quantitative analysis of ergothioneine bloodstains was conducted estimate the age that bloodstain donors. Blood...
Precise estimation of treatment effects is crucial for evaluating intervention effectiveness. While deep learning models have exhibited promising performance in counterfactual representations effect (TEE), a major limitation most these that they treat the entire population as homogeneous group, overlooking diversity across potential subgroups varying effects. This restricts ability to precisely estimate and provide subgroup-specific recommendations. In this paper, we propose novel model,...
Deep learning models have demonstrated promising results in estimating treatment effects (TEE). However, most of them overlook the variations outcomes among subgroups with distinct characteristics. This limitation hinders their ability to provide accurate estimations and recommendations for specific subgroups. In this study, we introduce a novel neural network-based framework, named SubgroupTE, which incorporates subgroup identification effect estimation. SubgroupTE identifies diverse...
이 연구는 고령화 사회로 접어든 농촌 지역에서 주민의 다수를 구성하는 노인층에 주목하여 이들이 어떻게 공동체 집단을 구성하고, 분화하며, 재편되는지, 그 양상을 파악하고 분석한 것이다. 화성시사편찬실에 근무하며 진행한 구술조사와 농어촌 마을 기초조사 결과를 바탕으로 하여, 중 다섯 개 마을의 노인 집중적으로 들여다봤다. 주요 연구방법으로 구술사 인터뷰를 선택하여 65세 이상의 토박이 원주민과 귀농 · 귀촌한 이주민 노인들의 주관적이고 개인적인 관점, 인식, 목소리를 파악하였다. 이제까지 농촌의 노인들, 특히 농업에 종사하는 주민들은 특징과 정체성이 세분화되어 고려되기보다는, 단일한 성격의 집단, 혹은 하나의 틀에 맞추어 인식되는 경향이 있었다. 그러나 화성시 조사한 결과, 이들은 성장배경, 교육 수준, 경제력, 소속된 문중의 위상, 문화자본, 마을공동체에서 중요하게 여기는 가치, 귀촌의 목적 등 여러 요인에 따라 서로 다른 정체성을 표출하며 다양한 유형과 층위를 형성했다. 또...
Major depressive disorder (MDD) can present a variety of clinical presentations and has high inter-individual heterogeneity. Multiple studies have suggested various subtype models related to symptoms, etiology, sex, treatment response. Employing different regimens is common when treating MDD, identifying effective therapeutics requires time. Frequent attempts failures lead diagnosis resistance, the heterogeneity responses among individuals makes it difficult understand interpret biological...