A5023546983- Bipolar Disorder and Treatment
- Dementia and Cognitive Impairment Research
- Electronic Health Records Systems
- Patient-Provider Communication in Healthcare
- Pharmacological Effects and Toxicity Studies
- Health Systems, Economic Evaluations, Quality of Life
- Ethics in Clinical Research
- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Healthcare Systems and Technology
- Health Policy Implementation Science
- Clinical practice guidelines implementation
- Anesthesia and Neurotoxicity Research
- Schizophrenia research and treatment
- Electroconvulsive Therapy Studies
- Frailty in Older Adults
- Zebrafish Biomedical Research Applications
- Attention Deficit Hyperactivity Disorder
- Neurological Disorders and Treatments
- Mental Health and Patient Involvement
- Epilepsy research and treatment
- Reproductive Biology and Fertility
- Neonatal and fetal brain pathology
- Adolescent and Pediatric Healthcare
- Palliative Care and End-of-Life Issues
University of Chicago
2022-2024
National Opinion Research Center
2022-2024
KLE University
2022-2023
Merck (Germany)
2023
University of Minnesota
2017-2021
University of Toronto
2016-2017
Minneapolis VA Health Care System
2017
Brown University
2017
HealthPartners
2017
Jehangir Clinical development Centre
2017
DNA (cytosine-5) methylation represents one of the most widely used mechanisms enduring cellular memory. Stable patterns are established during development, resulting in creation persisting phenotypes. There is growing evidence that nervous system has co-opted a number development to subserve formation long term In this study, we examined role methyltransferase (DNMT) activity might play regulating induction synaptic plasticity. We found within promoters for reelin and brain-derived...
Aims: Stakeholder engagement is fundamental to comparative effectiveness research (CER), but lacks consistent terminology. This paper aims define stakeholder and present a conceptual model for involving stakeholders in CER. Materials & methods: The definitions were developed from literature search, expert input experience with the Center Comparative Effectiveness Research Cancer Genomics, proof-of-concept platform involvement priority setting CER study design. Results: Definitions...
An increasing amount of evidence suggests that the family nuclear factor κB (NF-κB) transcription factors plays an important role in synaptic plasticity and long-term memory formation. The present study investigated regulation NF-κB members p50, p65/RelA, c-Rel hippocampus response to metabotropic glutamate receptor (mGluR) signaling. Activation group I receptors (GpI-mGluRs) with agonist ( S )-3,5-dihydroxyphenylglycine (DHPG) resulted a time-dependent increase DNA binding activity p65,...
Abstract Objective We conducted a horizon scan to (1) identify challenges in patient-centered clinical decision support (PC CDS) and (2) future directions for PC CDS. Materials Methods engaged technical expert panel, scoping literature review, interviewed key informants. qualitatively analyzed interview transcripts, mapping findings the 4 phases translating evidence into CDS interventions (Prioritizing, Authoring, Implementing, Measuring) external factors. Results identified 12 development....
Supporting healthcare decision-making that is patient-centered and evidence-based requires investments in the development of tools techniques for dissemination outcomes research findings via methods such as clinical decision support (CDS). This article explores technical landscape CDS (PC CDS) gaps making PC more shareable, standards-based, publicly available, with goal improving patient care outcomes. assessment used: (1) a expert panel; (2) literature review; (3) interviews 18...
Abstract The design, development, implementation, use, and evaluation of high-quality, patient-centered clinical decision support (PC CDS) is necessary if we are to achieve the quintuple aim in healthcare. We developed a PC CDS lifecycle framework promote common understanding language for communication among researchers, patients, clinicians, policymakers. puts patient, and/or their caregiver at center illustrates how they involved all following stages: Computable Clinical Knowledge,...
Zebrafish have become a popular animal model for studying the development of alcohol addiction. Several behavioral paradigms addiction been developed zebrafish, including conditioned place preference, alcohol-induced tolerance, and withdrawal. However, choice preference tasks not established in zebrafish as yet. The ability to detect their environment is required or tasks. To our knowledge, it currently unknown whether are able immediately following bath immersion. In current study, we...
The Center for Comparative Effectiveness Research in Cancer Genomics completed a 2-year stakeholder-guided process the prioritization of genomic tests comparative effectiveness research studies. We sought to evaluate engagement procedures achieving project goals and identify opportunities future improvements.The evaluation included an online questionnaire, one-on-one telephone interviews facilitated discussion. Responses questionnaire were tabulated descriptive purposes, while transcripts...
Abstract Background Clinical decision support (CDS), which provides tools to assist clinical decision-making, can improve adherence evidence-based practices, prevent medical errors, and high-quality patient-centered care delivery. Publicly available CDS that uses standards express logic (i.e., standards-based CDS) has the potential reduce duplicative efforts of translating same evidence into across multiple health institutions. Yet development such is relatively new its only partially...
Patient-centered clinical decision support (PC CDS) includes digital health tools that patients, caregivers, and care teams in healthcare decisions incorporate patient-centered factors related to four components: knowledge, data, delivery, use. This paper explores the current state of each factor how promotes patient-centeredness healthcare. We conducted a literature review, reviewing 175 peer-reviewed grey literature, eighteen key informant interviews. Findings show need for more research...