A5037642442- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Cellular transport and secretion
- NF-κB Signaling Pathways
- Neuroscience and Neuropharmacology Research
- Neurological Disease Mechanisms and Treatments
- Neurobiology and Insect Physiology Research
- Acute Ischemic Stroke Management
Baylor College of Medicine
2006-2009
Academy of Athens
2004
Alexander Fleming Biomedical Sciences Research Center
2004
Texas A&M University
2004
Houston Advanced Research Center
2004
Mutations in the neuronal-specific microtubule-binding protein TAU are associated with several dementias and neurodegenerative diseases. However, effects of elevated accumulation on behavioral plasticity unknown. We report that directed expression wild-type vertebrate Drosophila adult mushroom body neurons, centers for olfactory learning memory Drosophila, strongly compromised associative memory, but conditioning-relevant osmotactic mechanosensory responses remained intact. In addition,...
An increasing amount of evidence suggests that the family nuclear factor κB (NF-κB) transcription factors plays an important role in synaptic plasticity and long-term memory formation. The present study investigated regulation NF-κB members p50, p65/RelA, c-Rel hippocampus response to metabotropic glutamate receptor (mGluR) signaling. Activation group I receptors (GpI-mGluRs) with agonist ( S )-3,5-dihydroxyphenylglycine (DHPG) resulted a time-dependent increase DNA binding activity p65,...