A5100650039- Ultrasound and Cavitation Phenomena
- Photoacoustic and Ultrasonic Imaging
- Ultrasound and Hyperthermia Applications
- Fluid Dynamics and Mixing
- Extracellular vesicles in disease
- Structural Analysis of Composite Materials
- Nanomaterials and Printing Technologies
- Textile materials and evaluations
- Particle Dynamics in Fluid Flows
- Innovative Microfluidic and Catalytic Techniques Innovation
- Nanoplatforms for cancer theranostics
- Microfluidic and Bio-sensing Technologies
- Mechanical Behavior of Composites
ETH Zurich
2023-2024
Ultrasound-responsive agents have shown great potential as targeted drug delivery agents, effectively augmenting cell permeability and facilitating absorption. This review focuses on two specific microbubbles nanodroplets, provides a sequential overview of their process. Particular emphasis is given to the mechanical response under ultrasound, subsequent physical biological effects cells. Finally, state-of-the-art in pre-clinical clinical implementation are discussed. Throughout review,...
Wall-attached bubbles can produce repeated jets under gentle ultrasound stimulation through the Faraday instability. We identify three distinct jetting regimes defined by frequency and bubble surface topology. demonstrate that these form via flow-focusing singularities following two collapse modes of interface: conical, producing a jet towards substrate, or parabolic, generating pair oppositely directed jets. Scaling laws governing events are derived, revealing universal self-similar...
Understanding the shell rheology of ultrasound contrast agent microbubbles is vital for anticipating their bioeffects in clinical practice. Past studies using sophisticated acoustic and optical techniques have made enormous progress this direction, enabling development models that adequately reproduce nonlinear behaviour coated microbubble under excitation. However, there also been puzzling discrepancies missing physical explanations dependency viscosity on equilibrium bubble radius, which...
Understanding bubble behaviour under ultrasound excitation is key for applications like industrial cleaning and biomedical treatments. Our previous work demonstrated that ultrasound-induced shape instabilities in microbubbles generate periodic jets capable of puncturing cells enabling targeted drug delivery (Cattaneo et al., 2024). This study investigates the physics these a controlled setup involving individual micrometric air bubbles on rigid substrates. Using dual-view imaging system...
Abstract Localization optoacoustic tomography (LOT) has recently emerged as a transformative super‐resolution technique breaking through the acoustic diffraction limit in deep‐tissue (OA) imaging via individual localization and tracking of particles bloodstream. However, strong light absorption red blood cells previously restricted per‐particle OA detection to relatively large microparticles, ≈5 µm diameter. Herein, it is demonstrated that submicron‐sized porous gold nanoparticles, ≈600 nm...
The pursuit of targeted therapies capable overcoming biological barriers, including the tenacious blood-brain barrier, has spurred investigation into stimuli-responsive microagents. This approach could improve therapeutic efficacy, reduce undesirable side effects, and open avenues for treating previously incurable diseases. Intravenously-administered ultrasound-responsive microbubbles are one most promising agents, having demonstrated potential in several clinical trials. However, mechanism...
The use of ultrasound-driven microbubbles presents a promising avenue for facilitating the localised delivery therapeutics by inducing controlled nanodamage on capillary walls. Despite tangible clinical evidence success this approach, underlying physical mechanism leading to remains under debate. In study, time-resolved side-view visualisations elucidate interplay between soft substrates and clinically relevant ultrasound regimes. Our findings reveal existence four distinct regimes bubble...
Understanding the shell rheology of ultrasound contrast agent microbubbles is vital for anticipating their bioeffects in clinical practice. Past studies using sophisticated acoustic and optical techniques have made enormous progress this direction, enabling development models that adequately reproduce nonlinear behaviour coated microbubble under excitation. However, there also been puzzling discrepancies missing physical explanations dependency viscosity on equilibrium bubble radius, which...