A5085530978- 3D Printing in Biomedical Research
- Fluid Dynamics and Mixing
- Cellular Mechanics and Interactions
- Advanced biosensing and bioanalysis techniques
- HER2/EGFR in Cancer Research
- Tendon Structure and Treatment
- Algal biology and biofuel production
- Silk-based biomaterials and applications
- Nanofabrication and Lithography Techniques
- RNA Interference and Gene Delivery
- Ultrasound and Cavitation Phenomena
- Wound Healing and Treatments
- Photochromic and Fluorescence Chemistry
- Ultrasound and Hyperthermia Applications
- Skin Protection and Aging
- Monoclonal and Polyclonal Antibodies Research
- Hydrogels: synthesis, properties, applications
- Viral Infectious Diseases and Gene Expression in Insects
ETH Zurich
2022-2025
Small molecules are frontline therapeutics for many diseases; however, they often limited by their poor solubility. Therefore, hydrophobic small encapsulated or prepared as pure drug nanoparticles. Navitoclax, used to eliminate senescent cells, is one such molecule that faces challenges in translation due its hydrophobicity and toxic side effects. Further, cells exhibit context-dependent pathologic beneficial properties, it preferable locally. To formulate navitoclax enable local treatment,...
Protein isolation is an essential tool in cell biology to characterize protein abundance under various experimental conditions. Several protocols exist, tailored culture or tissue sections, and have been adapted particular downstream analyses (e.g., western blotting mass spectrometry). An increasing trend bioengineering use three-dimensional (3D) hydrogel-based scaffolds for culture. In principle, the same can be used extract from constructs. However, practice yield quality of recovered...
Hyperosmotic stress occurs in several diseases, but its long-term effects are largely unknown. We used sorbitol-treated human fibroblasts 3D culture to study the consequences of hyperosmotic skin. Sorbitol regulated many genes, which help cells cope with condition. The most robustly gene encodes serine protease 35 (PRSS35). Its regulation by was dependent on kinases p38 and JNK transcription factors NFAT5 ATF2. identified different collagens collagen-associated proteins as putative PRSS35...
Mechanical deformation of skin creates variations in fluid chemical potential, leading to local changes hydrostatic and osmotic pressure, whose effects on mechanobiology remain poorly understood. To study these effects, we investigate the specific influences pressure primary human dermal fibroblasts three-dimensional hydrogel culture models. Cyclic hyperosmotic stress enhanced percentage cells expressing proliferation marker Ki67 both collagen PEG-based hydrogels. Osmotic also activated p38...
Abstract In oncology, the advent of monoclonal antibody (mAbs) therapeutics represents a major breakthrough in various cancer diseases. However, these biotherapies often necessitate iterative hospital visits for intravenous infusion that can alter patient’s quality life and contribute to chronic saturation hospitals. Interestingly, subcutaneous formulations mAbs offer promising alternative facilitating faster administration compared with traditional methods, while still maintaining same...
The pursuit of targeted therapies capable overcoming biological barriers, including the tenacious blood-brain barrier, has spurred investigation into stimuli-responsive microagents. This approach could improve therapeutic efficacy, reduce undesirable side effects, and open avenues for treating previously incurable diseases. Intravenously-administered ultrasound-responsive microbubbles are one most promising agents, having demonstrated potential in several clinical trials. However, mechanism...