A5029431243- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Receptor Mechanisms and Signaling
- Neurotransmitter Receptor Influence on Behavior
- Ion channel regulation and function
- Neuroscience and Neural Engineering
- Genetic Neurodegenerative Diseases
- Neurological disorders and treatments
- Proteins in Food Systems
- Seed Germination and Physiology
- Soybean genetics and cultivation
- Functional Brain Connectivity Studies
Goethe University Frankfurt
2019-2023
Goethe Institute
2019
Functional diversity of midbrain dopamine (DA) neurons ranges across multiple scales, from differences in intrinsic properties and connectivity to selective task engagement behaving animals. Distinct vitro biophysical features DA have been associated with different axonal projection targets. However, it is unknown how this translates firing patterns projection-defined subpopulations the intact brain. We combined retrograde tracing single-unit recording labelling mouse brain create an vivo...
The low-threshold L-type calcium channel Ca
Abstract The in vivo firing patterns of ventral midbrain dopamine neurons are controlled by afferent and intrinsic activity to generate sensory cue prediction error signals that essential for reward-based learning. Given the absence intracellular recordings during last three decades, subthreshold membrane potential events cause changes neuron remain unknown. To address this, we established whole-cell obtained over 100 spontaneously active, immunocytochemically-defined...
Germline de novo missense variants of the CACNA1D gene, encoding pore-forming α1 subunit Cav1.3 L-type Ca2+ channels (LTCCs), have been found in patients with neurodevelopmental and endocrine dysfunction, but their disease-causing potential is unproven. These alter channel gating, enabling enhanced activity, suggesting inhibition as a therapeutic option. Here we provide proof nature such gating-modifying using mice (Cav1.3AG) containing A749G variant reported patient autism spectrum disorder...
Abstract The firing pattern of ventral midbrain dopamine neurons is controlled by afferent and intrinsic activity to generate prediction error signals that are essential for reward-based learning. Given the absence intracellular in vivo recordings last three decades, subthreshold membrane potential events cause changes neuron patterns remain unknown. By establishing stable whole-cell >100 spontaneously active anaesthetized mice, we identified repertoire signatures associated with distinct...