A5017144228- Neuroendocrine regulation and behavior
- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Olfactory and Sensory Function Studies
- Stress Responses and Cortisol
- Cell Image Analysis Techniques
- Medical Image Segmentation Techniques
- Neuropeptides and Animal Physiology
- Advanced Neuroimaging Techniques and Applications
- Cognitive Abilities and Testing
- Psychology of Moral and Emotional Judgment
- Biochemical effects in animals
- Tryptophan and brain disorders
- Hormonal Regulation and Hypertension
- Neuroinflammation and Neurodegeneration Mechanisms
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Ion channel regulation and function
- Receptor Mechanisms and Signaling
- Cancer-related gene regulation
- Genetic Neurodegenerative Diseases
- Neurological disorders and treatments
- AI in cancer detection
Innsbruck Medical University
2018-2023
Universität Innsbruck
2018-2023
Netherlands Institute for Neuroscience
2021-2023
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2018-2020
Friedrich Miescher Institute
2018-2019
Institute of Pharmacology
2018
National Institutes of Health
2018
Adaptive behavior critically depends on the detection of behaviorally relevant stimuli. The anterior insular cortex (aIC) has long been proposed as a key player in representation and integration sensory stimuli, implicated wide variety cognitive emotional functions. However, to date, little is known about contribution aIC interneurons processing. By using combination whole-brain connectivity tracing, imaging neural calcium dynamics, optogenetic modulation freely moving mice across different...
In cortical structures, principal cell activity is tightly regulated by different GABAergic interneurons (INs). Among these INs are vasoactive intestinal polypeptide-expressing (VIP+) INs, which innervate preferentially other providing a structural basis for temporal disinhibition of cells. However, relatively little known about VIP+ in the amygdaloid basolateral complex (BLA). this study, we report that have variable density distinct subdivisions mouse BLA. Based on anatomical,...
Germline de novo missense variants of the CACNA1D gene, encoding pore-forming α1 subunit Cav1.3 L-type Ca2+ channels (LTCCs), have been found in patients with neurodevelopmental and endocrine dysfunction, but their disease-causing potential is unproven. These alter channel gating, enabling enhanced activity, suggesting inhibition as a therapeutic option. Here we provide proof nature such gating-modifying using mice (Cav1.3AG) containing A749G variant reported patient autism spectrum disorder...
To accurately explore the anatomical organization of neural circuits in brain, it is crucial to map experimental brain data onto a standardized system coordinates. Studying 2D histological mouse slices remains standard procedure many laboratories. Mapping these challenging; due deformations, artifacts, and tilted angles introduced during preparation slicing process. In addition, analysis can be highly dependent on level expertise human operator. Here we propose computational tool for...
Abstract Learning drives behavioral adaptations necessary for survival. While plasticity of excitatory projection neurons during associative learning is studied extensively, little known about the contributions local interneurons. Using fear conditioning as a model learning, we find that behaviorally relevant, salient stimuli cause by tapping into microcircuit consisting precisely connected subtypes inhibitory By employing calcium imaging and optogenetics, demonstrate vasoactive intestinal...
Footshock self-experience enhances rodents' reactions to the distress of others. Here, we tested one potential mechanism supporting this phenomenon, namely that animals auto-condition their own pain squeaks during shock pre-exposure. In Experiment 1, pre-exposure increased freezing and 22 kHz vocalizations while listened audible pain-squeaks 2 3, test auto-conditioning theory, weakened noxious stimulus not trigger squeaks, compared protocols in which paired it with squeak playback against...
Understanding the brain connectome and anatomical organization of neural circuits in mouse using histological sections is a prominent area research neuroscience field. Accurate quantitative comparative analysis data requires precise mapping to common reference atlas. The existing methods rely either on 2D coronal atlases or 3D reconstruction prior registration. problem with former that are not always good match, since they do account for slicing angle. drawback latter registration only...
Summary Emotional contagion refers to the transmission of emotions from one conspecific another. Previous research in rodents has demonstrated that self-experience footshocks enhances how much an observer is affected by emotional state a pain or distress. We hypothesized auditory auto-conditioning contribute this enhancement: during observer’s own experience shocks, animal associates its audible nocifensive responses, i.e. squeaks, with negative affective induced shock. When later witnesses...
Abstract Background: The role of the cAMP/PKA signaling in molecular pathways involved fear memory is well established: PKA required for formation and a constraint extinction. Previously we reported that Prkar1a heterozygote (HZ) mouse was developed our lab to investigate Carney complex (CNC), disease caused by PRKAR1A mutations, showed brain region-specific increased activity associated with anxiety-like behavioral phenotype threat bias (Keil, 2010, 2013). We hypothesized Prkar1a+/- mice...