A5013547652- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Peptidase Inhibition and Analysis
- Fungal Biology and Applications
- Fungal and yeast genetics research
Centre for DNA Fingerprinting and Diagnostics
2013-2022
Manipal Academy of Higher Education
2018
A family of 11 GPI (glycosylphosphatidylinositol)-linked cell surface-associated aspartyl proteases (yapsins) in the human opportunistic fungal pathogen Candida glabrata is required for wall remodelling, pH homoeostasis, survival macrophages and virulence a murine model disseminated candidiasis. In present paper, we report new roles yapsins C. physiology implicate them first time regulation vacuole homoeostasis. study show that mutant lacking all yapsins, Cgyps1-11∆, possesses an enlarged...
Secretory proteins are key modulators of host–pathogen interaction. The human opportunistic fungal pathogen Candida glabrata lacks secreted proteolytic activity but possesses 11 glycosylphosphatidylinositol-anchored aspartyl proteases, also referred to as Yapsins (CgYps1–11), that essential for its virulence. To delineate the role CgYapsins in interaction with host cells, we have profiled, through liquid chromatography-tandem mass spectrometry (LC-MS/MS) approach, total secretome wild-type...
Invasive candidiasis poses a major healthcare threat. The human opportunistic fungal pathogen Candida glabrata, which causes mucosal and deep-seated infections, is armed with distinct virulence attributes, including family of 11 glycosylphosphatidylinositol-linked aspartyl proteases, CgYapsins. Here, we have profiled total membrane proteomes the C. glabrata wildtype proteases-deficient strain, Cgyps1-11Δ, by mass spectrometry analysis uncovered novel role for yapsins in glucose sensing...