Abstract The CD47-SIRPα axis functions as an immune checkpoint, transmitting a “don’t eat me” signal to prevent macrophage-mediated phagocytosis of tumor cells. While CD47 is expressed on most cells and highly induced in cells, SIRPα phagocytes, including macrophages type II conventional dendritic (cDC2s). Blocking the binding between shown promote antitumor immunity. However, mechanism how CD47-Sirpα blockade regulates DC still unclear. Here we demonstrated that anti-CD47 and/or anti-Sirpα...

Multiple reaction monitoring (MRM) is a powerful and popular technique used for metabolite quantification in targeted metabolomics. Accurate consistent quantitation of metabolites from the MRM data essential subsequent analyses. Here, we developed an automated tool, MRMQuant, metabolomic using high-throughput liquid chromatography-tandem mass spectrometry to provide users with easy-to-use tool accurate minimal human intervention. This has many user-friendly functions features inspect correct...

Treatment of lung cancer leptomeningeal carcinomatosis (LM) remains challenging partly due to the biological nature blood-brain barrier (BBB). Cisplatin has limited effects on LM, and it is notorious for neurotoxicity. Aptamers are small oligonucleotides considered as antibody surrogates. Here we report a DNA therapeutics, AptBCis1. AptBCis1 cisplatin-conjugated, BBB-penetrating, cancer-targeting aptamer. Its backbone, AptB1, was identified via

e20087 Background: Immunotherapy targeting PD-1/PD-L1 axis has yielded fruitful results in non-small cell lung cancers (NSCLCs). Evidences showed that treatment responses are likely correlated with tumor PD-L1 expression levels, which is especially true the first line setting. Results from Keynote-021 suggested pembrolizumab plus platinum-pemetrexed doublet came out better overall response rate and progression free survival as compared to chemotherapy alone even low-expression group....

Abstract Understanding species boundaries maintenance in the face of hybridization/introgression is an intriguing yet complex topic evolutionary biology. The underlying mechanisms, however, remain elusive. To address this, we propose to investigate role climatic shifts shaping genetic structure and influencing boundaries. We combine multilocus data distribution modeling explore how past current affect demographic history two Taiwan endemic gingers, Zingiber pleiostachyum Z. shuanglongense....

Invasive fungal infections, a serious problem among cancer patients, are increasing in incidence, and can cause morbidity mortality. Such infections may hinder additional treatment, especially for patients with leukemia. We report here our experiences the management of invasive infection acute A total 18 were enrolled study: 12 had microabscesses liver and/or spleen kidneys; four sinonasal infections; two pulmonary infections. Most (88.9%) received amphotericin B during treatment infection....

Abstract Aim The Massenerhebung effect (Mass elevation effect) refers to heat‐ or wind‐driven altitudinal distribution patterns of temperature‐dependent parameters among massifs with narrower range and lower around peripheral isolated mountains compared core continuous ones. Although common in ecology, this is rarely discussed population genetics. Here, we use genetic markers reveal also test the mountain‐ sky‐barrier hypotheses relevant pattern Acer morrisonense Taiwan's rugged topography...

Abstract Aim Rapid global warming is threatening biodiversity, and it will likely lead to varying degrees of local adaptation, particularly amongst plant species. Besides, rising temperatures frequently result in upslope distribution shifts towards climatic optima (i.e. the escalator effect) within a limited dispersal space, such as insular environments. Here, we integrated ecological genetic approaches investigate how climate change impact compositions spatial distributions Taiwan's endemic...

Hybridization frequently occurs in plant species. With repeated backcross, the introgression may influence evolutionary trajectories through entry of foreign genes. However, genetic admixture via hybridization events is often confused with ancestral polymorphism, especially closely related species that have experienced similar events. In Taiwan, two independent-originated endemic snakebark maples contrasted postglacial range expansion routes: northward and upward Acer caudatifolium downward...

EGFR is established as a driver of lung cancer, yet the regulatory machinery underlying its oncogenic activity not fully understood. PTEN-induced kinase 1 (PINK1) key player in mitochondrial quality control, although role cancer and regulation unclear. In this study, we show that PINK1 physically directly interacts with via C-terminal domain (PINK1-CTD) tyrosine domain. This interaction constituted an endogenous steric hindrance to receptor dimerization inhibited EGFR-mediated...

<div>Abstract<p>EGFR is established as a driver of lung cancer, yet the regulatory machinery underlying its oncogenic activity not fully understood. PTEN-induced kinase 1 (PINK1) key player in mitochondrial quality control, although role cancer and EGFR regulation unclear. In this study, we show that PINK1 physically directly interacts with via C-terminal domain (PINK1-CTD) tyrosine domain. This interaction constituted an endogenous steric hindrance to receptor dimerization...

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<div>Abstract<p>EGFR is established as a driver of lung cancer, yet the regulatory machinery underlying its oncogenic activity not fully understood. PTEN-induced kinase 1 (PINK1) key player in mitochondrial quality control, although role cancer and EGFR regulation unclear. In this study, we show that PINK1 physically directly interacts with via C-terminal domain (PINK1-CTD) tyrosine domain. This interaction constituted an endogenous steric hindrance to receptor dimerization...