A5073483630- Genetics, Aging, and Longevity in Model Organisms
- Circadian rhythm and melatonin
- Gastric Cancer Management and Outcomes
- Light effects on plants
- Gastrointestinal Tumor Research and Treatment
- Tissue Engineering and Regenerative Medicine
- Metastasis and carcinoma case studies
- Gastrointestinal disorders and treatments
- Congenital heart defects research
- Autism Spectrum Disorder Research
- Tracheal and airway disorders
- Helicobacter pylori-related gastroenterology studies
- Ubiquitin and proteasome pathways
- Neurobiology and Insect Physiology Research
- Plant Molecular Biology Research
- Receptor Mechanisms and Signaling
- Genetic Mapping and Diversity in Plants and Animals
- Viral-associated cancers and disorders
- Connective tissue disorders research
- Neurotransmitter Receptor Influence on Behavior
Shimonoseki City Hospital
2022
National Hospital Organization
2019-2021
Icahn School of Medicine at Mount Sinai
2015-2016
New York University
2011-2012
University of California, San Francisco
2010
Ernest Gallo Clinic and Research Center
2005
Gastrulation movements place endodermal precursors, mesodermal precursors and primordial germ cells (PGCs) into the interior of embryo. Somatic cell gastrulation are regulated by transcription factors that also control fate, coupling identity position. By contrast, PGCs in many species transcriptionally quiescent, suggesting they might use alternative strategies. Here, we show C. elegans internalize attaching to internal cells, which undergo morphogenetic pull We enrich HMR-1/E-cadherin at...
The mechanisms by which ethanol and inhaled anesthetics influence the nervous system are poorly understood. Here we describe positional cloning characterization of a new mouse mutation isolated in an N-ethyl-N-nitrosourea (ENU) forward mutagenesis screen for animals with enhanced locomotor activity. This allele, Lightweight (Lwt), disrupts homolog Caenorhabditis elegans (C. elegans) unc-79 gene. While Lwt/Lwt homozygotes perinatal lethal, heterozygotes dramatically hypersensitive to acute...
The mammalian esophageal musculature is unique in that it makes a transition from smooth to skeletal muscle, with most of this process occurring after birth. In order better understand the mechanisms control development, we investigated roles paired box transcription factor, PAX7, principal regulator myogenic progenitor cells. Previous studies showed Pax7 important for determining muscle composition. We characterized postnatal development −/− mice by analyzing morphology, composition, and...
Disruption of dopaminergic (DA) systems is thought to play a central role in the addictive process and pathophysiology schizophrenia. Although inheritance plays an important predisposition these disorders, genetic basis this not well understood. To provide additional insight, we have performed modifier screen mice designed identify mutations that perturb DA homeostasis. With background sensitized by mutation dopamine transporter (DAT), used random chemical mutagenesis screened for mutant...
A 73-year-old man visited our hospital for the treatment of an early gastric cancer (GC) lesion. We performed en bloc resection using endoscopic submucosal dissection (ESD) his GC The present lesion was Epstein-Barr virus (EBV)-associated poorly differentiated-type adenocarcinoma invading into layer. Recently, accumulating data has shown that risk lymph node metastasis from EBV without local lymphovascular infiltration is low. patient been in good health over three years since ESD. Some...
Epstein-Barr virus-associated gastric carcinoma (EBV GC) is a distinct subtype of GC [1] [2].) Many cases EBV have background Helicobacter pylori (HP)-positive chronic atrophic gastritis (CAG) [3]. How and when appears in the mucosa important information for understanding EBV-associated carcinogenesis. Almost all everyone seropositive, ordinary serological tests are not useful to detect positivity mucosa. The pathogenic role CAG unknown. We previously reported that 65.7 % (23 35) were...
ABSTRACT The physiological mechanisms governing health and disease exhibit complex interactions between multiple genes gene products. To study the dynamics of living systems, researchers need experimental methods capable producing calibrated, quantitative perturbations in vivo — that cannot be obtained using classical genetics, RNAi interference, or small molecule drugs. Recently, an auxin-inducible degron (AID) system has been developed to allow targeted degradation proteins small-molecule...
Abstract Objectives Based on the recent therapeutic trends for gastric cancer (GC), clinical impact of diagnosis Epstein–Barr virus (EBV)‐associated GC (EBVaGC) appears to be important. We retrospectively analyzed endoscopic and pathologic motifs lesions narrow number candidates EBV testing. Methods performed tests 32 upper gastrointestinal patients in setting. These were ordered by endoscopists or pathologists without an endoscopist's order. EBV‐encoded small RNA1 (EBER1) situ hybridization...
Gastrulation movements place endodermal precursors, mesodermal precursors and primordial germ cells (PGCs) into the interior of embryo. Somatic cell gastrulation are regulated by transcription factors that also control fate, coupling identity position. By contrast, PGCs in many species transcriptionally quiescent, suggesting they might use alternative strategies. Here, we show C. elegans internalize attaching to internal cells, which undergo morphogenetic pull We enrich HMR-1/E-cadherin at...
Early gastric cancer (EGC) with mixed-type histology is a significant risk factor for additional surgery after endoscopic submucosal dissection (ESD). On the other hand, Epstein-Barr virus-associated (EBVaGC) favorable regard to lymph node metastasis.We performed EBV detection in 13 ESD-proven lesions cases of early using EBV-encoded small RNA1 situ hybridization (EBER1 ISH).EBVaGC was diagnosed only one (7.7%) tested lesions. That EBVaGC patient underwent and there no residual lesion...