A5022881191- Organ Donation and Transplantation
- Transplantation: Methods and Outcomes
- Organ Transplantation Techniques and Outcomes
- Metabolism and Genetic Disorders
- Hemoglobinopathies and Related Disorders
- Neonatal Health and Biochemistry
- Childhood Cancer Survivors' Quality of Life
- Blood properties and coagulation
- Cancer survivorship and care
- Antifungal resistance and susceptibility
- Erythrocyte Function and Pathophysiology
- Iron Metabolism and Disorders
- Blood groups and transfusion
- Pleural and Pulmonary Diseases
- Pregnancy and preeclampsia studies
- Fuel Cells and Related Materials
- Fungal Infections and Studies
- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- Dermatology and Skin Diseases
- PARP inhibition in cancer therapy
- Otitis Media and Relapsing Polychondritis
- Ion Transport and Channel Regulation
- Congenital Ear and Nasal Anomalies
- Cerebral Venous Sinus Thrombosis
The University of Texas MD Anderson Cancer Center
2023-2024
Cooper University Hospital
2019-2023
University of Florida
2019-2021
Florida College
2016-2017
University of Central Florida
2016-2017
Osceola Regional Medical Center
2017
Pulmonary and Critical Care Associates
2017
Freeman Hospital
2014-2015
University of Sunderland
2014
Summary The lack of persistence infused T cells is a principal limitation adoptive immunotherapy in man. Interleukin (IL)-15 can sustain memory cell expansion when presented complex with IL-15Rα (15Rα/15). We developed novel in-vitro system for generation stable 15Rα/15 complexes. Immunologically quantifiable amounts IL-15 were obtained both and genes co-transduced NIH 3T3 fibroblast-based artificial antigen-presenting expressing human leucocyte antigen (HLA) A:0201, β2 microglobulin, CD80,...
Abstract Background Radiation therapy (RT) is a common treatment for adolescents and young adults (AYAs, 15–39 years old) with cancer; however, it may cause toxicities that affect health‐related quality‐of‐life (HRQOL). Thus, we assessed HRQOL in AYAs before, during, after RT. Methods We identified 265 who completed PROMIS® surveys before ( n = 87), during 84), or 94) Higher score represents more of the concept. Mean scores were compared to general US population minimally important...
Heterozygous pathogenic variants of SPTB cause hereditary spherocytosis (HS) in a quarter cases. A 14-day-old male presenting with persistent anemia and hyperbilirubinemia was diagnosed HS by increased red blood cell osmotic fragility decreased fluorescence on the eosin‐5'‐maleimide binding test. For his failure to thrive hypotonia, genetic sequencing revealed de novo variant gene (p.Q1034X) exon 15. This is predicted loss normal protein function either through truncation or...
Radiation therapy (RT) may cause toxicities in adolescents and young adults (AYAs, age 15-39 years) with cancer. However, the range of RT-related AYAs affect on health-related quality life (HRQOL) has not been well studied. We performed a cross-sectional study cancer who received RT to identify examine their impact HRQOL.
Angioedema is a severe form of an allergic reaction characterized by the localized edematous swelling dermis and subcutaneous tissues. Angiotensin-converting enzyme inhibitor-induced angioedema (ACEI-IA) that can be in some cases requiring advanced management measures. Fresh frozen plasma has been used off-labeled case reports to improve prevent worsening few ACEI-IA. We are reporting this increase awareness physicians widen their therapeutic options when encountering clinically significant...
Acute fatty liver of pregnancy (AFLP) is a rare disorder that typically presents in the third trimester. We report case 21-year-old woman with history intrauterine fetal demise at 19 weeks' gestation who developed fulminant failure 1 week after demise. She was diagnosed AFLP as per Swansea criteria. An orthotopic transplant attempted but unsuccessful. usually between 30th to 38th weeks gestation. However, it can occur postpartum period only highlighted our case.
12117 Background: ICIs are increasingly used in AYAs with cancer, however, limited data exists on the frequency and pattern of irAEs this population ability to rechallenge after irAEs. Methods: This retrospective study analyzed aged 15-39 melanoma who received treatment at MD Anderson Cancer Center from 2013 2023. Treatment cessation was defined as switching therapies or pausing original for over 3 months, resuming immunotherapy post-cessation. Results: A total 136 pts were included, 80 male...
9563 Background: Melanoma is the third most common cancer in adolescent and young adults (AYA), a unique cohort defined as patients between 15-39 years of age per National Cancer Institute. Immune checkpoint inhibitors (ICI) have changed landscape for advanced melanoma treatment, gut microbiota has been shown to remodel tumor microenvironment improve ICI efficacy. There paucity research this cohort, however studies show that AYA patients, general, historically not seen same survival gains...
Candida species are the most common cause of invasive fungal disease, and children with hematologic malignancy at increased risk. Non-albicans (NAC) now account for more than half all candidiasis (IC) carry a worse prognosis. We aimed to compare epidemiology, risk factors, organ dissemination, biomarkers outcomes in IC based on implicated evaluate trends antifungal resistance over time.
Background Gestational alloimmune liver disease (GALD) is characterized by maternal IgG-directed fetal hepatocyte damage and can lead to severe failure or infant death. Moreover, GALD associated with a near 90% risk of recurrence in subsequent pregnancies. Case We present case newborn patient delivered 32-year-old G2P1000 mother who received prolonged antenatal intravenous immunoglobulin (IVIG) treatment during the current pregnancy due neonatal death first child from GALD-related failure....
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To assess the impact of delayed cord clamping (DCC) for 45 seconds on hemoglobin at birth and close to discharge in very low weight (VLBW) infants compare modes delivery who received DCC.
Rajasekaran, Arun; Dayanand, Sandeep; Afridi, Faraz; Morales, Jorge; Batnyam, Uyanga; Sheshadri, Shubha; Pandit, Vinay
POEMS syndrome is an acronym for polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes, which a rare paraneoplastic disease of plasma cells. A mandatory criterion to diagnose the presence cell dyscrasia in leukemia most aggressive form. Early identification features critical patients identify underlying dyscrasias reduce morbidity mortality by providing early therapy. We present case 64-year-old male who presented with non-specific symptoms was found have...
Relapsing polychondritis is a very rare autoimmune disease characterised by relapsing inflammation of hyaline, elastic and fibrous cartilaginous tissues. The incidence estimated to be between 3.5 4.5 per million people year. Clinical signs symptoms can subtle, if left undiagnosed for prolonged period, airway involvement cause fibrosis the tracheobronchial wall, leading fixed stenosis. Eventually, this progress life-threatening tracheobronchomalacia due irreversible damage loss tissue...
Introduction Paediatric mechanical circulatory support (MCS) using either venoarterial ECMO or the Berlin Heart is performed for select cases of heart failure at our institution. candidates endure an uncertain wait a donor with interim MCS employed as bridge to transplantation. Death secondary complications raises possibility organ donation. We describe three recent successful recovery from donors in situ cannulae. Case Reports Patient (I) was 5-year old female suffering cardiac arrest post...
Introduction: Increasing the usage of hearts from marginal donors and after circulatory death (DCD) has potential to expand donor pool. Such may be resuscitated when subjected ex vivo perfusion. In addition, this provide an opportunity for viability testing prior transplant. We describe a novel perfusion system designed reanimate porcine DCD hearts. The same was subsequently tested using human heart brainstem-dead donor. Method: first phase study 23 were procured following death. All period...