A5057194029- Myasthenia Gravis and Thymoma
- Tactile and Sensory Interactions
- Multisensory perception and integration
- Pain Mechanisms and Treatments
- Peripheral Neuropathies and Disorders
- Antifungal resistance and susceptibility
- Heart Rate Variability and Autonomic Control
- Cardiovascular Syncope and Autonomic Disorders
- RNA Research and Splicing
- Color perception and design
- Motor Control and Adaptation
- Amyotrophic Lateral Sclerosis Research
- Neurogenetic and Muscular Disorders Research
- Olfactory and Sensory Function Studies
- Neurological and metabolic disorders
- Thermoregulation and physiological responses
- Tendon Structure and Treatment
- Herpesvirus Infections and Treatments
- Vasculitis and related conditions
- Forensic Toxicology and Drug Analysis
- Facial Nerve Paralysis Treatment and Research
- Sarcoidosis and Beryllium Toxicity Research
- Peripheral Nerve Disorders
- Autoimmune Neurological Disorders and Treatments
- Ergonomics and Musculoskeletal Disorders
Hennepin Healthcare Research Institute
2024
Northwestern University
2024
Mayo Clinic
2024
University of North Carolina at Chapel Hill
2010-2024
Deleted Institution
2023
University of North Carolina Health Care
2021-2022
Eastern Virginia Medical School
2003-2005
Background: The etiology of sensory neuropathies is often not found. We tested the hypothesis that metabolic syndrome (MS) may be associated with painful neuropathy, in absence frank diabetes. Methods: Clinical and quantitative neuropathy assessments were performed on 10 patients MS, 20 MS type 2 diabetes (10 recent onset >5 years duration), healthy, age-matched subjects. Intraepidermal nerve fiber density (IENF) mean dendrite length (MDL) determined by immunofluorescence skin biopsies using...
Mutations in HNRNPA1 encoding heterogeneous nuclear ribonucleoprotein (hnRNP) A1 are a rare cause of amyotrophic lateral sclerosis (ALS) and multisystem proteinopathy (MSP). hnRNPA1 is part the group RNA-binding proteins (RBPs) that assemble with RNA to form RNPs. hnRNPs concentrated nucleus function pre-mRNA splicing, mRNA stability, regulation transcription translation. During stress, hnRNPs, mRNA, other RBPs condense cytoplasm stress granules (SGs). SGs implicated pathogenesis...
Abstract Introduction/Aims Therapeutic plasma exchange (TPE) is sometimes used as maintenance therapy for the treatment of myasthenia gravis (MG). Efgartigimod a newly approved monoclonal antibody targeting neonatal Fc receptor, effectively reducing immunoglobulin G levels in MG. The aim this study was to describe clinical experience switching patients from TPE efgartigimod infusions. Methods A retrospective review medical records performed on previously treated with diagnosis MG and...
To describe a novel subtype of autoimmune myopathy, immune-mediated megaconial myopathy (IMMM), myopathologically characterized by giant mitochondria (megaconia).
ABSTRACT Little is known about the linkage between physical properties of fluids and how they are perceived. Therefore, 15 with diverse rheologies were characterized physically by three participants via a novel “force plate” (FP) device. Perceptual ratings made 20 participants, 27 “sensory” attributes (e.g., oily ) 14 “emotional” arousing ). Factor analyses decomposed measures obtained from FP into factors approximating friction, normal vibration , tangential ; sensory watery, textured,...
The tactile and thermal sensitivity of diverse regions the human body have been documented extensively, with one exception being scalp. Additionally, sensory changes may accompany hair loss from scalp in androgen-related alopecia (ARA), but formal quantitative testing (QST) has not reported respect this. Therefore, light touch detection thresholds were obtained at nine sites forehead site, using Semmes-Weinstein filaments (Von Frey hairs), for warming cooling skin baseline temperature, 28...
Background/Study Context: Sensory function degrades with age, well-established reductions in tactile spatial acuity, vibrotactile sensitivity, and thermosensation, to name but three aspects of perception. Such age-related losses might be partially stemmed by ongoing experience tasks requiring high levels manual dexterity or analogous expertise; individuals who are highly expert skills that have a fundamental component can show improved as compared nonexperts. Methods: Eighty (17 males, 63...
Little is known about the tactile–perceptual structure of fluids. Therefore, ten fluids with diverse, characterized rheologies were rated by 16 females, on 27 sensory attributes (e.g., "slippery") and 14 emotional "enjoyable") via five-point categorical scales. Fluids assessed against volar forearm underarm, sites that commonly experience contact during use personal care products. Application was either participant to their own body ("self-applied") or experimenter participant's...
Abstract Muscle-specific kinase (MuSK) antibody is seen in 4%–10% of patients with myasthenia gravis (MG), 40% these reporting bulbar weakness as the initial symptom. We present case a 40-year-old woman MuSK MG whose only presenting symptom was progressive respiratory insufficiency necessitating BiPAP use 16–24 hours daily. She unresponsive to treatment for cardiac and pulmonary causes thus referred neurology. Initial workup directed toward autoimmune genetic myopathies unrevealing....
To describe a "wearing off" phenomenon between standard maintenance infusions of ravulizumab for subset patients with acetylcholine receptor antibody positive generalized myasthenia (AChR gMG).
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ABSTRACT Mutations in HNRNPA1 encoding heterogeneous nuclear ribonucleoprotein (hnRNP) A1 are a rare cause of amyotrophic lateral sclerosis (ALS) and multisystem proteinopathy (MSP). hnRNPA1 is part the group RNA-binding proteins (RBPs) that assemble with RNA to form ribonucleoproteins. hnRNPs major subclass evolutionarily conserved RBPs primarily concentrated nucleus heavily involved pre-mRNA splicing, mRNA stability transcriptional/translational regulation. During times stress, standard...
Sunday, April 26April 14, 2020Free AccessMiller-Fisher Syndrome (MFS) with Delayed Bilateral Facial Nerve Palsy: Imaging and Electrodiagnostic Findings, Treatment Outcome (2789)Charles Port, Anahit Mehrabyan, Victor LinAuthors Info & AffiliationsApril 2020 issue94 (15_supplement)https://doi.org/10.1212/WNL.94.15_supplement.2789 Letters to the Editor
Hippocampal ischemia is a rare complication of cocaine abuse that has been thought to arise from vasospasm, anoxic injury, and/or catecholaminergic excitotoxicity. We present two cases patients abusing cocaine, who presented with an acute onset anterograde amnesia due bilateral hippocampal ischemia, and had different outcomes. Case 1 49-year-old male history IV heroin after being found down for unknown period time. He awoke no memory events leading up hospitalization was unable retain new...
To examine the impact of mycophenolate mofetil (MMF) and azathioprine (AZA) on incidence development skin lesions in patients with myasthenia gravis (MG).