A5041679841- Amyotrophic Lateral Sclerosis Research
- Cancer-related gene regulation
- RNA Research and Splicing
- Diabetes Treatment and Management
- PI3K/AKT/mTOR signaling in cancer
- 3D Printing in Biomedical Research
- Neuroblastoma Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Histone Deacetylase Inhibitors Research
- Neurogenetic and Muscular Disorders Research
- Single-cell and spatial transcriptomics
- RNA modifications and cancer
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Pluripotent Stem Cells Research
- RNA and protein synthesis mechanisms
University of Pennsylvania
2021-2025
Vanderbilt University
2024
Institute of Molecular Biology and Biophysics
2021
Dana-Farber Cancer Institute
2014
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder typically characterized by insoluble inclusions of hyperphosphorylated TDP-43. The mechanisms underlying toxic TDP-43 accumulation are not understood. Persistent activation p38 mitogen-activated protein kinase (MAPK) implicated in ALS. However, it unclear how MAPK affects proteinopathy. Here, we show that p38α inhibition reduces pathological phosphorylation, aggregation, cytoplasmic mislocalization, and...
Mutations in the ALK tyrosine kinase receptor gene represent important therapeutic targets neuroblastoma, yet their clinical translation has been challenging. The ALK(F1174L) mutation is sensitive to inhibitor crizotinib only at high doses and mediates acquired resistance ALK-translocated cancers. We have shown that combination of an downstream signaling induces a favorable response transgenic mice bearing ALK(F1174L)/MYCN-positive neuroblastoma. Here, we investigated molecular basis this...
Mutations in HNRNPA1 encoding heterogeneous nuclear ribonucleoprotein (hnRNP) A1 are a rare cause of amyotrophic lateral sclerosis (ALS) and multisystem proteinopathy (MSP). hnRNPA1 is part the group RNA-binding proteins (RBPs) that assemble with RNA to form RNPs. hnRNPs concentrated nucleus function pre-mRNA splicing, mRNA stability, regulation transcription translation. During stress, hnRNPs, mRNA, other RBPs condense cytoplasm stress granules (SGs). SGs implicated pathogenesis...
Abstract Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder typically characterized by insoluble inclusions of hyperphosphorylated TDP-43. The mechanisms underlying toxic TDP-43 accumulation are not understood. Persistent activation p38 mitogen-activated protein kinase (MAPK) implicated in ALS. However, it unclear how MAPK affects proteinopathy. Here, we demonstrate that inhibition p38α reduces pathological phosphorylation, aggregation, cytoplasmic mislocalization, and...